Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cdc48"”.
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Cooperativity and communication in archaeal Cdc48·20S, an ancient proteolytic machine
… peptidases for regulated proteolysis. Cdc48 is a highly conserved AAA+ homohexameric unfoldase which is made up of two AAA+ rings. Each ring can, in principle, bind and hydrolyzing ATP, but it is unclear what roles are played by each ring and how they coordinate their activities. A …
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In vitro reconstitution of the ubiquitylation and disassembly of the eukaryotic replisome
… known, viz the E3 ligase SCFDia2 and segregase Cdc48, very little was known about the mechanism of CMG disassembly. In the process of learning more about the disassembly of the replicative helicase from chromatin, I reconstituted the ubiquitylation of CMG and thereafter the disassembly of CMG …
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Molecular analysis of vesicle biogenesis during autophagy
… This study indicates the requirement of Cdc48 and its major substrate-recruiting factor Shp1 for efficient PMN Summary 2 as well as macroautophagy. The human homologues of Cdc48 / Shp1 p97 / p47 are involved in human mitotic Golgi reassembly. This p97 / p47 complex is thought to extract a …
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Regulation der Transkription durch das Ubiquitin/Proteasom-System
… Protein vor und wird so durch die konservierte CDC48UFD1/NPL4-Segregase, die in dieser Arbeit für S. cerevisiae beschrieben wurde, erkannt. CDC48UFD1/NPL4 entwindet in einer ATP-abhängigen Reaktion den membranständigen Komplex und ermöglicht den Transport von SPT23 p90 in den Zellkern. …
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Characterization of a Novel Chromatin-Induced Mechanism that Couples Microtubule Disassembly and Nuclear Re-Formation
… of the Aurora B kinase by the Triple A-ATPase Cdc48/p97, which physically extracts the protein from chromatin at anaphase. Aurora B is the catalytic subunit of the Chromosome Passenger Complex (CPC), which promotes microtubule polymerization and spindle formation from mitotic chromosomes. …
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Biochemical and Structural Insights into VCP Unfoldase and WRN Helicase Complexes
… protein (VCP or p97 in mammals, Cdc48 in yeast) is an essential member of the AAA (ATPases associated with diverse cellular activities) protein superfamily. As its family name suggests, VCP function is implicated in a broad range of biological pathways including protein …