Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Cdc25A"”.
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The Role of CDC25A in Ultraviolet-induced Nonmelanoma Skin Tumorigenesis
Cell division cycle 25A (CDC25A) is a dual-specificity phosphatase that removes inhibitory phosphate groups from cyclin-dependent kinases, allowing cell cycle progression. Activation of cell cycle checkpoints following DNA damage can result in degradation of CDC25A, leading to cell cycle arrest. …
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The Dynamics of the Unreplicated DNA Checkpoint in Xenopus laevis Embryos and Extracts
… role of protein kinase Chk1 and the phosphatase Cdc25A in the DNA replication checkpoint. In the absence of active Chk1, Cdc25A activates cyclin dependent kinases (Cdks) allowing the cell to progress into S or M phase. Chk1 regulates cell cycle arrest in the presence of unreplicated DNA in …
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
… proliferation. CDC25 family members, including CDC25A, CDC25B and CDC25C, are over-expressed in many human cancers, often correlating with poor prognosis. In this research, the hypothesis that Erbb2 up-regulation of CDC25 phosphatases increases cell proliferation and contributes to skin cancer …
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Design of Peptide Ligands for 14-3-3ε, and Exploring the Role of Residue Types in Ligand Recognition by 14-3-3 Proteins
… protein phosphatase cell division cycle 25 A (CDC25A) is over expressed and mislocalized from nucleus to cytoplasm in cSCC. The anti-apoptosis activity of 14-3-3ε is dependent on its interaction with cytoplasmic CDC25A. Thus, inhibiting interaction between 14-3-3ε and CDC25A is an attractive …
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Chemical Genetic Studies of Tumor Suppressors in the Developing Zebrafish
… for cell cycle deficiencies is the zebrafish cdc25a mutant standstill. This mutant suffers from a G2/M arrest due to activation of the checkpoint protein ATM such that ATM knockdown or inhibition rescues the cell cycle. Additional knockdown studies reveal that the unique zebrafish cdc25 gene …
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The Role of Chk2 and Wee1 Protein Kinases during the Early Embryonic Development of Xenopus laevis
… a pre-MBT checkpoint by promoting degradation of Cdc25A and phosphorylation of Cdks. Embryos expressing DN-Chk2 developed normally until gastrulation and then underwent apoptosis. Conversely, low doses of wt-Chk2 blocked radiation-induced apoptosis. These data indicate that Chk2 inhibits apoptosis …
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Role of retinoblastoma protein in the development of liver cancer
… checkpoint proteins such as Gadd45a, MAD2 and CDC25a all show a dysregulation in their activities. In conclusion Rb loss leads to aberrant regulation of p53 and induces DNA damage, this superimposed on a background of a lack of cell cycle control predisposes the hepatocyte to becoming a …
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An investigation of the role of TRIB2 in steady state and stressed haematopoiesis
… found that TRIB2 interacts with CDC25B/C but not CDC25A isoform. Overexpression of TRIB2 promotes polyubiquitination and degradation of CDC25C. Hence, future works are warranted to examine TRIB2-CDC25C interaction in the context of developing thymocytes and in T-cell acute lymphoblastic leukaemia, …
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Delineating The Mechanism(S) of Bdnf/Trkb Mediated Proliferation In Neuroblastoma
… regulation. Protein levels of pRB, CDK2, CDK4, CDC25A, cyclin D1, and cyclin E were analyzed following BDNF stimulation. We found that BDNF mediated activation of TrkB induces multiple common proximal signaling pathways including the anti-proliferative Fyn pathway and drives cell cycle machinery …