Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Cdc25"”.
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
… kinase activators, the cell division cycle 25 (CDC25) phosphatases, and also activates Erbb family members indirectly through reactive oxygen species (ROS)-inhibition of tyrosine phosphatases to stimulate proliferation. CDC25 family members, including CDC25A, CDC25B and CDC25C, are …
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Pyp3 Involvement in Mitotic Control and Cell Growth in Fission Yeast
… The kinases wee1+, mik1+ and the phosphatases cdc25+, pyp3+ play opposite roles in the regulation of p34cdc2 activity. In cells lacking wee1, tyrosine phosphorylation of p34cdc2 is carried out by Mik1; in cells lacking cdc25+, the activity of the Pyp3 phosphatase is responsible for tyrosine …
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A model of the checkpoint response of the cell cycle of frog-egg extracts in the presence of unreplicated DNA
… Factor (MPF), and its key regulatory proteins Cdc25 and Wee1, are central parts of this cell cycle engine. Maintaining the fidelity of the DNA during the cell cycle is critical for successful propagation of the cell lineage. In the presence of unreplicated DNA, the cell cycle engine''s progress …
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Physiological and pathological role of serine 96 phosphorylation in the regulation of androgen receptor
… Among them, we found two compounds targeting Cdc25, a known activator of CDK2. Cdc25 modulation altered serine 96 phosphorylation, toxicity and transcriptional activity of polyQ-AR in cells. Our results support the idea that Cdc25 represents a potential candidate to develop new therapeutic …
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Investigation of the role of polyploidization in glial cells during the development of the drosophila nervous system
… both the Notch signaling pathway and the String Cdc25 phosphatase are critical in determining whether SPG endocycle or endomitose. Experiments manipulating the percentage of cells that are endocycling versus endomitotic highlight key differences between endocycling and endomitotic SPG. We find …
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Dual-specific protein phosphatases in the <i>Archaea</i>
… (cPTPs), low molecular weight (LMW PTPs), and Cdc25 PTPs, have converged upon a common catalytic mechanism and active site sequence, mainly, the phosphate-binding loop encompassing the PTP signature motif (H/V)<b>C</b>(X)₅<b>R</b>(S/T) and an essential Asp residue on a surface loop. There is …
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DNA stress checkpoint control in Arabidopsis thaliana by WEE1
… cell cycle inhibitor that, together with CDC25, controls CDK activity and consequently the G2/M progression in yeast and animals. The same control mechanism is utilized by the DNA damage checkpoint to induce a cell cycle arrest upon DNA stress. In plants, a homolog of the WEE1 gene is …
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Mechanisms of cell cycle remodeling at the MBT during the development of Xenopus laevis embryos
… XChk1, a kinase that activates Wee1 and inhibits Cdc25, the phosphatase opposing Wee1. Like GST-D34Xic1, XChk1 inhibits cyclin E/Cdk2 and delays the degradation of cyclin E. In contrast to GST-D34Xic1, XChk1 elevates the level of Wee1 at a time when sibling controls begin the MBT, despite cell …
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Chemical Genetic Studies of Tumor Suppressors in the Developing Zebrafish
… for cell cycle deficiencies is the zebrafish cdc25a mutant standstill. This mutant suffers from a G2/M arrest due to activation of the checkpoint protein ATM such that ATM knockdown or inhibition rescues the cell cycle. Additional knockdown studies reveal that the unique zebrafish cdc25 gene …
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An investigation of the role of TRIB2 in steady state and stressed haematopoiesis
… of String which is an orthologue of mammalian CDC25 phosphatases in order to arrest cell cycle during embryonic development. Here, we showed that the role of Tribbles-induced degradation of String is evolutionarily conserved in TRIB2. We found that TRIB2 interacts with CDC25B/C but not CDC25A …
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Part 1 Design, Synthesis and Bioactivity of a Phosphorylated Prodrug for the Inhibition of Pin1; Part 2 Conformational Specificity of Cdc25c Substrate for Cdc2 Kinase using LC-MS/MS
… cell cycle regulatory phosphoproteins, including Cdc25 phosphatase,Cdc27, p53 oncogene, c-Myc oncogene, Wee1 kinase, Myt1 kinase, and NIMA kinas, have been confirmed as substrates of Pin1. Pin1 was also observed to be overexpressed in a variety of cancer cell lines, and the inhibitors of Pin1 …
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Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors
… mechanism. These cell cycle enzymes include Cdc25, Cdc27, Cyclin D1, Myt1, Wee1, NIMA, Cdc2, Plk1 and c-Myc. Recent research has revealed that Pin1 is overexpressed in a variety of cancer cell lines and Pin1 inhibitors inhibit proliferation activity of several cancer cells overexpressing …
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Characterisation of the molecular complexes that regulate the G2/M checkpoint of the eukaryotic cell cycle
… mitosis, and subsequent dephosphorylation by the CDC25 phosphatases, initially the B isoform, leads to mitotic onset. The aim of this research was the biophysical and/or biochemical characterisation of the molecular complexes that form at the G2 checkpoint to regulate entry into mitosis. CDK1 and …
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Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism
… function of its biological substrates, including Cdc25, c-Jun, and p53. The expression of Pin1 correlates with cyclin D1 levels, which contributes to cancer cell transformation. Overexpression of Pin1 promotes tumor growth, while its inhibition causes tumor cell apoptosis. Because Pin1 is …
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The Dynamics of the Unreplicated DNA Checkpoint in Xenopus laevis Embryos and Extracts
… role of protein kinase Chk1 and the phosphatase Cdc25A in the DNA replication checkpoint. In the absence of active Chk1, Cdc25A activates cyclin dependent kinases (Cdks) allowing the cell to progress into S or M phase. Chk1 regulates cell cycle arrest in the presence of unreplicated DNA in …