Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Ccnd1"”.
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Six1 Is Important for Myoblast Proliferation Through Direct Regulation of Ccnd1
… are bound and modulated by Six1. In particular, Ccnd1 was found to display a similar expression pattern as Six1 in growing myoblasts and its expression was found to be directly controlled by Six1. Furthermore, Ccnd1 over-expression was sufficient to rescue the Six1-knockdown associated cell cycle …
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A study of the relationship of the internal endocrine environment to the p53 network, cyclin D1 and replication licensing proteins in breast cancer
… D1 was seen in 63% of cancers studied whilst CCND1 amplification was identified in 30%. CCND1 amplification was significantly associated with cyclin D1 protein overexpression (p<0.001; Fisher’s exact test) and both CCND1 amplification and cyclin D1 protein expression with oestrogen receptor …
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Characterisation of HIF2A targets identifies MYC as a key determinant of HIF2A dependency in ccRCC
… CRISPR/Cas9 screening revealed that *MYC* and *CCND1* are key dependencies in ccRCC *in vivo*, in addition to highlighting key differences between *in vitro* and *in vivo* dependencies. By leveraging a doxycycline-inducible HIF2A expression system, combined with exogenous constitutive expression …
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Genetic and Epigenetic Characterisation of Breast Tumours
… genomic aberrations at chromosome 11q13 in CCND1 (11q13.3)-amplified breast tumours and identified cores proximal and distal of the CCND1 locus that were frequently amplified. Additionally, we found that CCND1 amplification and overexpression was most frequent in luminal B tumours. In Papers …
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Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer
… The markers examined were associated with CCND1 amplification (Chk1 and β-arrestin1), which has previously been linked to a potential adverse effect of tamoxifen, or with epithelial-mesenchymal transition (Snail), a biological process crucial for the development of metastasis. …
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Expansion of neural stem cells as a treatment for ischemic stroke
… Überexpression der Zellzyklusregulatoren Cdk4/Ccnd1 (4D) in neuralen Stammzellen (NSZ) der SGZ oder SVZ ihre G1 Phase verkürzt und dadurch zu einer erhöhten Proliferationsrate führt. Dies hatte eine höhere Anzahl an neugeborenen Neuronen zur Folge, welche die Performance von Mäusen in …
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HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators
… involved in cell cycle progression such as MYC, CCND1 and TGFa. Furthermore, enhancer profiling performed through H3K27ac ChIP-seq demonstrated the activation of enhancer elements in the close vicinity of these genes. Moreover, HIF2α ChIP-seq showed that it bound the same enhancers suggesting …
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An In Vivo Functional Genomics Screen Identifies New Regulators of Tumorigenesis in Non-Small Cell Lung Cancer
… six genes required for survival in vitro (BRCA1, CCND1, MED1, PHB, HNRNPU, and PELP1), and three genes that were required for tumor survival in vivo, but not in vitro: FOXA1, HDAC1, and NCOR2. None of these genes were mutated by full exome sequencing of H1819, however FOXA1 was found to be …
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Study of the role of miR-204 in photoreceptor development
… this aspect, I demonstrated that Cyclin D1 (<i>Ccnd1</i>) and <i>Cd44</i> play a key role in miR-204-induced photoreceptor differentiation, as assessed by both <i>in vivo</i> and <i>in vitro</i> experiments. Moreover, I generated two medaka transgenic lines exclusively overexpressing miR-204 …
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Decoding Dynamic Gene Regulation in Hair Cell Development and Regeneration
… for two hair cell cofactors (Hist1h1c and Ccnd1) and a novel DNA-binding sequence for the transcription factor Fiz1. In zebrafish, lateral-line neuromasts can regenerate damaged hair cells by expressing genes such as <em>atoh1a</em>—the master regulator of hair cell fate—in progenitors …
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Type I Insulin-Like Growth Factor Receptor Tyrosine Kinase As A Molecular Target In Mantle Cell Lymphoma
… translocation that juxtaposes the proto-oncogene CCND1, which encodes cyclin D1 at 11q13 to the IgH gene at 14q32. MCL patients represent about 6% of all new cases of Non-Hodgkin’s lymphomas per year or about 3,500 new cases per year. MCL occurs more frequently in older adults – the average age at …
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Redes de coexpresión génica de muestra única como herramienta para la estimación de sobrevida en cáncer de mama
… de alto grado en redes individuales, tales como CCND1, ERBB2, C1QBP, USP31, entre otros. La coincidencia entre las regiones altamente conectadas y la localización de genes centrales refuerza la idea de que ciertos segmentos cromosómicos actúan como núcleos organizativos de la red transcriptómica …
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Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model
… RTPCR. Relative mRNA expressions levels of MMP9, CCND1 and Notch1 were found to be decreased in KGr and KGG groups compared to KC group in pancreatic tissue samples. Relative expression levels of CCND1 were decreased in KGr and KGG groups in Liver tissue samples. MMP9 relative expression levels …
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CYCLIN D1 AND WILMS TUMOR TRANSCRIPTION FACTOR-1 (WT1): POTENTIAL DIAGNOSTIC AND THERAPEUTIC MARKERS IN SMALL ROUND BLUE CELL TUMORS OF CHILDHOOD
… The protein Cyclin D1 (CD1), encoded by the CCND1 gene, belongs to the highly conserved cyclin family, whose members function as regulators of CDKs (cyclin-dependent kinase) through-out the cell cycle. CD1 serves as a key sensor and integrator of extracellular signals of cells to promote …
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Identifying genetic biomarkers for diagnosis of prostate cancer in South African men
… ZNF185, DKK3, PTGS2, FOXO1, ARNTL, TNFRSF10D, CCND1, and DLC1, upregulated genes included; CDH1, MKI67, TMPRSS2, ERG, CDKN2A, FASN, and AR but were not statistically significant. At a fold change threshold of 1.5, the following additional genes were downregulated in the PCa group with p values …
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Genetic changes in the development of multiple myeloma
… and SMM with translocations directly involving CCND1 and CCND3 suggesting a possible role of 13 in the progression of disease specifically in these genetic sub-groups. However, it was clear that, excluding 13 in these sub-groups, standard interphase-FISH abnormalities are insufficient to predict …
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Genetic analyses, protein expression, type and function with clinical and immunological correlates in human papillomavirus associated head and neck neoplasia
… within the p53 oncogenic pathway (e.g. CDKN2A / CCND1). In addition to this, a testis-specific gene not normally expressed in somatic cells, SYCP2, showed a consistently elevated fold change from baseline in pre-malignant and malignant tissue. A subtle immune defect has long been thought to …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
… In addition, knockout of Meis1 activates Ccnd1, which subsequently promotes regeneration of skeletal muscle, and reduces expression of Casp8 and Casp3, thus preventing limb tissue from ischemia-induced apoptosis. Our innovative findings offer great potential to ultimately lead to new drug …