Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Caveolin-1"”.
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Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma
… well to results obtained by standard methods. Caveolin-1 is a major structural component of caveolae, which are plasma membrane microdomains implicated in the regulation of intracellular signaling pathways. Altered caveolin-1 expression is thought to be involved in several important human …
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Impact of Caveolin-1 Expression and Microvessel Density on the Prognosis of Upper Urinary Tract Transitional Cell Carcinoma
PURPOSE: Caveolin-1 is a principal component of caveolae membranes and plays a regulatory role in several signal pathways. It may also be crucial in the organization of caveolae of endothelial cells and in regulating endothelial cell differentiation and angiogenesis. Caveolin-1 has been reported to …
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Regulation of receptor signaling and membrane trafficking by beta1,6-branched n-glycans and caveolin-1/cholesterol membrane domain organization
… opposes receptor sequestration by oligomerized caveolin-1 (Cav1) domains overriding its negative regulation of epidermal growth factor receptor (EGFR) signaling, cell surface diffusion and tumor growth. These results identify Cav1 as a conditional tumor suppressor. I also demonstrate that Cav1 …
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Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer
… co-</p> <p>expression of cathepsin B and caveolin-1 was found in IBC patient </p> <p>biopsies, thus validating our in vitro data. To determine whether the </p> <p>uPA and cathepsin B present at the cell surface is localized </p> <p>specifically to caveolae and investigate if caveolae are a …
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A Study of the Sequestration of Melanin-Concentrating Hormone Receptor-1 in Caveolae: A Potential Mode of Cell Signaling Regulation by an Appetite-Stimulating Hormone
… centrifugation MCHR1 co-localizes with caveolin-1, suggesting a role for lipid rafts in receptor dynamics. This thesis will examine the extent of interaction between caveolin-1 and MCHR1. The first aim will be to determine the degree of co-localization of receptor and caveolin-1 under …
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Melanin-Concentrating Hormone Receptor-1 is Enriched in Lipid Rafts and the Effects of Lipid Raft Integrity on Receptor Signaling
… to note, fat cells accumulate caveolae markers -caveolin-1 and cholesterol -during this process. Certain GPCRs and their associated downstream signaling molecules co-localize with caveolae membranes. This thesis seeks to demonstrate that MCHR-1 is enriched in lipid rafts and that a possible …
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Identification of the receptor for cellular internalization of an anti-nucleic acid antibody, 3D8 scFv
… molecules were observed between 3D8 scFv-HSPGs-caveolin 1, and 3D8 scFv-CSPGs-caveolin 1 in HeLa cells. Furthermore, internalization of 3D8 scFv was significantly reduced in HS/CS-deficient CHO cells (pgsA-745), compared to in wild-type CHO cells. These data provide the evidence for both HSPGs …
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Expression und Funktion von Caveolin bei glialen Zellen, insbesondere Oligodendrozyten
Caveolin-haltige Mikrodomänen (CMD) sind sphingomyelin-, glykosphingolipid- und cholesterinreiche Membranabschnitte innerhalb der Plasmamembran. Zu ihren physiologischen Aufgaben gehören u.a. der vesikuläre Transport und die Signaltransduktion. Caveolae sind als Sonderform von CMD anzusehen. Anhand …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… in this process, cultured cells were depleted of caveolin-1 (siRNA). Similar to inhibitors, TNFα failed to induce protein-tyrosine nitration, activate NFkB or enhance adhesion molecule expression in cells lacking caveolin-1. These findings were corroborated in vivo using Cav1KO animals. Our …
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Hormonal regulation of phosphodiesterase 3B in adipocytes
… rat and mouse adipocytes, 3T3-L1 adipocytes and caveolin-1 knock out mouse adipocytes. The study on PDE3B phosphorylation shows that PDE3B is multisite phosphorylated in response to both insulin and catecholamines. We were able to identify six phosphorylation sites on PDE3B namely; 273, S296, …
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… of the cholesterol transport machinery, caveolin-1 (CAV1), is neither required for intestinal cholesterol transport or sensitivity to the novel cholesterol absorption blocking agent, ezetimibe. This rules out a critical role for caveolin-1 and lends further support to the contention that …
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Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI
… the juvenile brain. To this end, the endothelial caveolins and c-Jun N-terminal kinases (JNKs) were identified as proteins of interest in the regulation of brain endothelial permeability after injury. These were investigated under a three-fold aim. The first was to characterize the acute and …
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THE ROLE OF CAVEOLAE IN THE FORMATION OF ABDOMINAL AORTIC ANEURYSMS
… lacking the main structural protein of caveolae, caveolin-1, did not develop AAA compared to WT animals in spite of hypertensive blood pressures measured by telemetry in both groups. This finding suggests that intact Ang-II signaling remains in place in caveolin-1 knockout mice. To begin to …
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Lipotoxicity in smooth muscle
… lipotoxicity in smooth muscle, we overexpressed caveolin-1 (Cav-1), a protein found in caveolae. Cav-1 increased CD36 expression and redistribution inside the cell and increased apoptosis. These studies may have implications for atherosclerosis and bladder dysfunctions that result from obesity, …
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Integration of signalling in smooth muscle caveolae
… to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. Ca2+-sensitization is a contractile process depending …
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Structural and Functional Characterization of GAPR-1, a Mammalian Plant Pathogenesis-related Protein in Lipid-enriched Microdomains of the Golgi Complex
… sequence for myristoylation, a putative caveolin-binding domain, a coiled-coil structure, and an isolelectric point (pI) of 9.4, suggesting that GAPR-1 is a highly hydrophilic protein (Eberle, H. B. et al. 2002). In this thesis, this structural information, was used to i) study the …
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Toll like Receptor 4-Mediated Immune Responses in the Bladder Epithelium
… activation by LPS. In addition, we reveal that Caveolin-1, Rab27b, PKA, and MyRIP are components of the exocytic compartment and that they form a complex involved in the exocytosis of bacteria. The ability of TLR4 to mediate the rapid cytokine response, the inhibition of bacterial invasion, and …
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Molecular Mechanisms Regulating Chemokine Receptor CXCR4 Signaling and Trafficking
… with CXCR4 at the plasma membrane and with caveolin-1, a protein that is enriched in caveolae (a specialized lipid raft). Disrupting caveolae using caveolin-1 siRNA or nystatin, a cholesterol-depleting agent, significantly attenuated CXCR4-induced ERK-1/2 activation. Based upon our data, we …
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Lipid Rafts in Pancreatic Beta- and Alpha-cell Stimulus-secretion Coupling
… expression of lipid raft constituent proteins, caveolin-1/2 in pancreatic beta-cells; and caveolin-2 in alpha-cells. A variety of membrane proteins (ion channels and SNARE proteins) critical for beta- and alpha-cell stimulus-secretion coupling were found to be associated with cholesterol-rich …
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