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Showing 1 to 4 of 4 for “"Cav2.3"”.

  1. Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function

    Kjalarsdottir, Lilja2012

    … is the R-type voltage-gated calcium channel, CaV2.3, which is highly upregulated by VitD in human and mouse islets. We identified a strong VDR binding element within intron 7 of the Cav2.3 gene that is conserved in mouse and man. With previous reports linking Cav2.3 activity with Type 2 …

    utswmed Repository record

  2. Investigating the Role of R-type Channel Mutations in Developmental and Epileptic Encephalopathies

    Khousakoun, DevonCumming School of Medicine2026

    … which encodes the voltage-gated calcium channel Cav2.3 (R-type). Mutations in CACNA1E have been identified in patients with DEEs; however, the mechanisms by which these mutations affect channel function, and thus their relationship to DEEs, remain largely unknown. Previous research has begun to …

    calgary Repository record

  3. The Calcium Channel Gamma6 Subunit Analysis of Function and Determination of a Sequence Motif Critical for Its Effect

    Lin, ZuojunUniversity of Illinois at Urbana-Champaign2015

    … that co-expression of gamma6 subunit decreases Cav2.3 dependent calcium current density. Previous studies using chimeric gamma subunits indicate that the N-terminal region, including the first transmembrane domain (TM1), is critical for the inhibitory function of the gamma6 subunit. In this …

    uiuc Repository record

  4. Neuronal calcium sensor 1 deficiency affects mRNA levels of genes involved in regulation of calcium homeostasis, ATP synthesis and mitochondrial stress in highly vulnerable Substantia nigra dopaminergic neurons

    Simons, Carsten MichaelUniversität Ulm

    ulm-diss Repository record