Global ETD Search
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Showing 1 to 5 of 5 for “"Cav2.1"”.
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MODULATION OF VOLTAGE-GATED CALCIUM CHANNEL BY A SYNAPTIC PROTEIN AND GANGLIOSIDE
… splice-variant-selective manner. Notably, the CaV2.1 and CaV2.2 channels are mutually exclusively spliced to produce either CaV2.1[EFa] or CaV2.1[EFb], and CaV2.2[EFa] or CaV2.2[EFb] respectively. Snapin selectively increased the current density of CaV2.1[EFb] and CaV2.2[EFa], but not …
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Voltage gated calcium channels – molecular targets for trigeminal neuralgia
… CACANA1A, CACNA1G, and CACNA1H, that encode CaV2.1, CaV3.1 and CaV3.2 channels, respectively, were investigated. First, we characterised the biophysical properties of these mutations using whole-cell patch-clamp recordings in tsA-201 cells. Second, we investigated the role of CaV3.2 channels …
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PURINERGIC TRANSMISSION IN MIGRAINE: ROLE OF P2Y RECEPTORS IN THE SPINAL-TRIGEMINAL SYSTEM IN VIVO AND IN VITRO
… 1 (FHM1), was introduced in the α1 subunit of CaV2.1 calcium channels by a gene targeting approach (van den Maagdenberg et al., 2004). While there was no difference in BK-induced P2Y receptor upregulation in SCGs, between from wild type and CaV2.1 α1 R192Q mutant KI cultures, a significant …
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Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain
… target voltage gated calcium channels (VGCCs) Cav2.1 and Cav2.2. We found that the Wfs1 cell type in the anterior cingulate cortex is necessary for the affective pain circuitry. Compared to control mice, the Wfs1 silenced mice exhibited a significantly reduced aversion to formalin-paired …
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Molecular Mechanisms of Presynaptic Plasticity and Function in the Mammalian Brain
Synaptic plasticity describes efficacy changes in synaptic transmission and ranges in duration from tens to hundreds of milliseconds (short-term), to hours and days (long-term). Short-term plasticity plays crucial roles in synaptic computation, information processing, learning, working and …