Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Cav1"”.
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T cell receptor- and calcium-induced Gli signalling in CD8+ T cell effector function
… that L-type voltage-gated Ca2+ channels (Cav1) are crucial for Gli1 induction. However, the role of Gli1 in the context of cytotoxic CTL function in vivo has not been explored. Furthermore, expression and functional relevance of GLI transcription factors in human CTLs is unknown as is the …
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Regulation of receptor signaling and membrane trafficking by beta1,6-branched n-glycans and caveolin-1/cholesterol membrane domain organization
… sequestration by oligomerized caveolin-1 (Cav1) domains overriding its negative regulation of epidermal growth factor receptor (EGFR) signaling, cell surface diffusion and tumor growth. These results identify Cav1 as a conditional tumor suppressor. I also demonstrate that Cav1 is a negative …
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The Role of EHD2 in Endothelial Cells
<p>The role of EHD2 in terms of Cav1 interaction had not been previously characterized and was the main goal of this research. Cav1 has been shown to lead to the ubiquitination of Rac1. Because of this, the role of EHD2 in Rac1 regulation was investigated. An increase in long-term migration in …
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The Characterization of Nemadipine and Migrazole as Small Molecule Tools for Use in the Nematode Caenorhabditis elegans
… to 1,4-dihydropyridines (DHPs), which target the Cav1 calcium channel and are used clinically to lower blood pressure. Phenotypic and genetic evidence suggest that nemadipine targets the worm Cav1 channel, EGL-19. To identify the target of nemadipine in an unbiased manner, I performed a forward …
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MODULATION OF VOLTAGE-GATED CALCIUM CHANNEL BY A SYNAPTIC PROTEIN AND GANGLIOSIDE
… Moreover, snapin preferentially modulated CaV1.3 channel by interacting with the I-II loop region but not on the other calcium channel of CaV1 families. In addition, voltage-gated calcium channels were modulated by anti-ganglioside antibodies. The antibodies against ganglioside are found in …
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… the cholesterol transport machinery, caveolin-1 (CAV1), is neither required for intestinal cholesterol transport or sensitivity to the novel cholesterol absorption blocking agent, ezetimibe. This rules out a critical role for caveolin-1 and lends further support to the contention that Niemann-Pick …
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Mechanisms of plasticity at the axon initial segment
… calcineurin, which acts downstream of L-type (Cav1) voltage-gated calcium channel activation. Moreover, calcineurin signalling is sufficient for AIS relocation. Whilst studying the timecourse of AIS relocation, I also discovered that the AIS is subject to a much more rapid form of plasticity. …
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Intestinal Adaptation in Pediatric Short Bowel Syndrome : Controlled Assessment of Duodenal Mucosa after Extensive Bowel Resection
… growth factor (TGF)β2 and Caveolin1 (CAV1). In addition, compared to controls, patients on PN demonstrated elevated mRNA expression of Claudin 1 (CLDN1), Mucin 2 (MUC2) and Glucose transporter, GLUT1 (SLC2A1) and decreased expression of NLR family CARD containing 4 (NLRC4) (P<0.005 for …
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LOCALIZED WNT3A-SOURCES INSTRUCT MITOTIC ORIENTATION: DISSECTING THE WNT3A-TRANSDUCTION MECHANISM COUPLED WITH NUMA MACHINERY
… effectors including LRP6, β-catenin, DVL2 and Cav1 are implicated in the spindle axis alignment towards the Wnt3a source. In addition, we demonstrate that Gai/LGN/NuMA complexes at the cell cortex together with astral MTs, are essential for Wnt3a-dependent spindle orientation. Proximity …
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Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue
… PRKAA2, FOXO1, SIRT1), and other proteins (GHR, CAV1, ADIPOQ, TNF1) was also measured. Dry matter intake, blood glucose and NEFA were not significantly different in both groups. Milk production had the tendency to produce more milk in HGM cows after 6 wks of lactation. Rate of lipogenesis and …
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Effects of weaning age and maternal nutrition on gene expression of longissimus muscle of beef steers
… through activation of: a) miR-103 that inhibits CAV1 that destabilizes INSR increasing insulin resistance, b) miR-143 that inhibits DLK1 that inhibits adipocyte differentiation through ERK1/2 activation, c) miR-21 that impaired TGFBR2-induced inhibition of adipocyte differentiation and seems to …