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Showing 1 to 20 of 28 for “"Caulobacter crescentus"”.
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Characterization of the partitioning protein ParB in Caulobacter crescentus
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Global characterization of the Pho regulon in Caulobacter crescentus
… system. In this thesis, I use the model organism Caulobacter crescentus to characterize the response to phosphate limitation. I use ChIP-Seq on the transcriptional regulator PhoB to globally map the Pho regulon in Caulobacter in both phosphate-starved and -replete conditions. I find that the …
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Spatiotemporal Model of the Asymmetric Division Cycle of Caulobacter crescentus
The life cycle of Caulobacter crescentus is of interest because of the asymmetric nature of cell division that gives rise to progeny that have distinct morphology and function. One daughter called the stalked cell is sessile and capable of DNA replication, while the second daughter called the …
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Regulatory pathways controlling cell division after DNA damage in Caulobacter crescentus
… damage response in the [alpha]-proteobacterium Caulobacter crescentus and identified two damage-induced cell division inhibitors. sidA is an SOS-induced division inhibitor whereas didA is induced in an SOS-independent fashion. Unlike most division inhibitors, SidA and DidA do not disrupt the …
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SciP : a novel inhibitor of CtrA transcriptional activity in Caulobacter crescentus
… In this thesis, I use the model system Caulobacter crescentus to examine the regulation of CtrA, the essential transcription factor at the core of the Caulobacter cell cycle regulatory network. CtrA regulates the activity of approximately 100 cell cycle genes many of which are critical …
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New mechanisms in transcription regulation and chromosome organization in Caulobacter crescentus
… two DNA-binding proteins from the bacterium Caulobacter crescentus; one transcription factor, GcrA, and one NAP, CnpA. First, I found that GcrA, an essential cell-cycle regulator in Caulobacter, activates transcription by a new mechanism. Unlike most transcription factors that bind to …
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Illuminating the function of a master regulator of Caulobacter crescentus gene expression
… for ribosome biogenesis and translation. The Caulobacter crescentus cell cycle has been well-characterized and represents a powerful model system for studying the regulation of global gene expression patterns and "just-in-time" transcription. Here, we provide evidence that the Caulobacter GcrA …
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Mathematical Model of the Cell Cycle Control and Asymmetry Development in Caulobacter crescentus
Caulobacter crescentus goes through a classic dimorphic cell division cycle to adapt to the stringent environment and reduce intraspecific competition. Caulobacter mother cell gives rise to two progenies with distinct morphology - a motile swarmer cell equipped with a flagellum and a sessile …
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Phosphorylation-based control of cellular asymmetry and the cell cycle in Caulobacter crescentus
… biology. In this work, I use the model organism Caulobacter crescentus to investigate how intracellular asymmetry within the mother cell is translated into the formation of two developmentally distinct daughter cells. Caulobacter is an alpha-proteobacterium that always divides asymmetrically to …
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Gene transfer agents promote survival and DNA repair during stationary phase for Caulobacter crescentus
… Here, I demonstrate that the α-proteobacterium Caulobacter crescentus produces bona fide GTAs. The production of Caulobacter GTAs is tightly regulated by a newly identified transcription factor, RogA, that represses gafYZ, the direct activators of GTA synthesis. Cells lacking rogA or expressing …
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The role of the phasin PhaP in promoting polyhydroxybutyrate (PHB) granule formation in Caulobacter crescentus
… To that end we have studied PHB accumulation in Caulobacter crescentus. Under conditions of nitrogen limitation but with abundant glucose available, C. crescentus accumulates PHB to ~12% of its cdw. We have quantitatively examined the levels of the PHB synthase, the major granuleassociated …
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A deadly hug : contact-dependent killing by Caulobacter crescentus, via cell surface-associated glycine-zipper proteins
… aquatic environments where the a-proteobacterium Caulobacter crescentus thrives. Here, I describe the discovery and characterization of a new type of bacteriocin in C. crescentus. The Cdz toxin is composed of two small hydrophobic proteins, each harboring an extended glycine-zipper motif often …
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Regulation of cell fate asymmetry in Caulobacter crescentus by a complex of two component signaling proteins
… into differential cell fates remain unknown. Caulobacter crescentus provides an excellent model to study this process because every division is asymmetric. One daughter cell, the stalked cell, is sessile and commits immediately to S phase. The other daughter, the swarmer cell, is motile and …
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Quantitative Modeling of the Molecular Mechanism Controlling the Asymmetric Cell Division Cycle in <i>Caulobacter crescentus</i>
<i>Caulobacter crescentus</i> is an important model organism for studying regulation of cell growth, division and differentiation in prokaryotes. <i>C. crescentus</i> undergoes asymmetric division producing two progeny cells with identical genome but different developmental programs: the "swarmer" …
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The participation of the partitioning protein para in the coordination of the bacterial cell cycle in Caulobacter crescentus
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Mathematical modeling of molecular mechanisms governing cell cycle progression in Caulobacter crescentus and differentiation of immune system progenitor cells
… cell cycle of the model prokaryotic organism, Caulobacter crescentus. Caulobacter is a uniquely successful oligotrophic bacterium, found abundantly in freshwater systems. While it is not a pathogenic species, Caulobacter is extremely well studied due to its distinguishable asymmetrical …
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Polymer models of chromosomes
… consecutive chromosomal loops. In the bacterium Caulobacter Crescentus, we showed that the chromosome is organized as a dense array of supercoiled plectonemes interspersed by highly transcribed regions free of plectonemes. Finally, for human interphase chromosomes, we showed that the equilibrium …
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Stochastic Modeling and Simulation of Reaction-Diffusion Biochemical Systems
… to the spatiotemporal regulatory network in Caulobacter crescentus is included. A stochastic model based on Turing pattern is exploited to demonstrate the bipolarization of a scaffold protein, PopZ, during Caulobacter cell cycle. In addition, the stochastic simulation of the spatiotemporal …
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Toxin-antitoxin systems in bacteria : targets, mechanisms, and specificity
… SocAB, a novel TA system in the bacterium Caulobacter crescentus. Unlike canonical TA systems, in which the antitoxin is less stable than the toxin, I found that the toxin SocB is unstable and constitutively degraded by the protease ClpXP. This degradation requires its antitoxin, SocA, …
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Stochastic Modeling and Simulation of Multiscale Biochemical Systems
… studies a stochastic spatiotemporal model of the Caulobacter crescentus cell cycle. A two-dimensional model based on a Turing mechanism is investigated to illustrate the bipolar localization of the protein PopZ. However, stochastic simulations are often impeded by expensive computational cost for …
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