Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Cationic liposomes"”.
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Turning stealth liposomes into cationic liposomes for anticancer drug delivery
… reported passive tumor targeting by PEGylated liposomes (stealth liposomes) have resulted in their higher tumor accumulation. However their interaction with cancer cells has been minimal due to the steric hindrance of the PEG coating. This dissertation reports two approaches to enhance the …
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Design of vaccine nanotechnology-based delivery systems, the effect of CpGODN TLR9 agonist-protein antigen conjugates anchored to liposomes
… or encapsulation/adsorption of CpGODN into/onto liposomes resulting in enhanced immunopotency compared to coadministration of free CpGODN and antigen. Despite the advances in the field, the effect of conjugation of TLR9 to antigen in combination with liposomes on the immunogenicity of …
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Design of Lipid and Polymeric Carriers for Nucleic Acid Delivery
… delivery. These included: i) to develop novel cationic lipids for plasmid, oligonucleotide, and siRNA delivery; ii) to develop a novel polymeric delivery system, polyethylene glycol (PEG) based bio–conjugate, for oligonucleotide delivery; iii) to develop a novel bio–conjugate delivery system …
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Formulation and characterisation of an effective particulate delivery vehicle for the novel sub-unit vaccine antigen, Ag85B-ESAT-6
… both physico-chemically and immunologically, cationic liposomes based on the potent adjuvant dimethyl dioctadecyl ammonium (DDA). These studies demonstrated that addition of the immunomodulatory trehalose dibehenate (TDB) enhanced the physical stability of the system whilst also adding further …
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IL -10 gene therapy for the treatment of pulmonary inflammation
… to develop a protocol for in vivo gene transfer. Cationic liposomes represent a class of nonviral vectors that hold great promise as gene delivery vehicles. However, recent studies have shown that they may be associated with some toxicity. We tested the hypothesis that the positive charge of …
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Synthesis and conformational study of trans-2-aminocyclohexanol-based pH-triggered molecular switches and their application in gene delivery
… such a switch, when incorporated into cationic liposomes, provides a novel design of the pH-sensitive helper lipids for gene delivery. Protonation of TACH molecules results in a strong intramolecular hydrogen bond between the amino and its neighboring hydroxyl groups, which triggers a …