Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Cationic antimicrobial peptides"”.
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Organization of the Streptococcal ExPortal and its Interaction with Cationic Antimicrobial Peptides
… infections. I investigated the interaction of cationic antimicrobial peptides with the streptococcal ExPortal to provide insights into how this secretory organelle is organized and how it may be targeted by this mechanism of innate immunity.</p><p>Cationinc antimicrobial peptides: CAPs) …
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Computational studies on polyunsaturated fatty acid uptake and its effects on antimicrobial resistance
… This uptake has been linked to increased antimicrobial resistance, motility, biofilm formation, and virulence phenotypes. This research was a collaboration between Dr. David Giles and Dr. Bradley Harris to computationally investigate the uptake mechanism for the uptake of long chain fatty …
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Antimicrobial Effectors Act Cooperatively to Stress Salmonella in the Macrophage Phagosome
… virulence. We hypothesize that during infection, cationic antimicrobial peptides (CAMPs) from the macrophage transiently disrupt the outer membrane. SodCII is released from the periplasm and degraded. SodCI is both tethered within the periplasm and is protease resistant. This hypothesis provides a …
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Stress And Survival Of Enterobacteriaceae: Studies Of Dehydration Tolerance And Polymyxin Resistance
… investigate resistance to polymyxins, which are cationic antimicrobial peptides used as last-resort antibiotics in Gram-negative bacteria. The polymyxin resistance network differs in network topology, which refers to how the regulators are connected to and interact with each other, across several …
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A Physicochemical and Biophysical Investigation into the Role of Lysyl- Phosphatidylglycerol in the Membrane of Staphylococcus aureus under mild acidic conditions
… of innate defences including mild acidity and cationic antimicrobial peptides (CAMPs). Reduced sensitivity of S. aureus to these defences appears partly due to the increased biosynthesis of lysyl-phosphatidylglycerol (L-PG) in its plasma membrane. The precise mechanisms by which L-PG …
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The interaction of antimicrobial peptides with lipopolysaccharide aggregates and model membranes.
… and the aggregate structures. The amphiphilic cationic antimicrobial peptides (CAPs) LL37 and LFb possess putative anti-endotoxic activities and were therefore studied using small-angle neutron scattering (SANS) and cryo transmission electron microscopy (cryo-TEM) to assess any modication …
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Antimicrobial Activity of Human Leukocyte Defensin HNP-4 Against Gram-negative Bacteria
<p>Human neutrophils (PMN cells) contain four peptides known as alpha (α)-defensins or HNP 1-4. The peptides have broad-spectrum antibiotic activity. HNP 1-3 are major neutrophil components. They differ by only one amino acid residue. HNP-4 is found in small amounts, and has a different sequence. …
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Periplasmic Modification of the 1-Phosphate Group of Lipid A in Gram-Negative Bacteria.
… mutants are extremely sensitive to the cationic peptide polymyxin, thus, demonstrating the importance of modifying the 1-position of lipid A. Furthermore, this work describes another enzyme, YeiU (renamed LpxT), which specifically utilizes the carrier lipid undecaprenyl pyrophsphate …