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Showing 1 to 9 of 9 for “"Cathepsin G"”.
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Expression, Purification, and Characterization of the Mast Cell Proteases Chymase and Cathepsin G.
… and the serine proteases, tryptase, Chymase, and cathepsin G (CatG). These proteases are stored and released from mast-cell granules upon activation by antigen binding to IgE immunoglobulins on the cell surface or by direct injury. In this study, chymase and CatG were expressed as active enzymes …
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Bioengineering the Expression of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, and C-Reactive Protein in Yeast
… enzyme. The neutrophil serine proteases human cathepsin G (hCatG) and human neutrophil elastase (HNE) were expressed in P. pastoris and HNE was also expressed in K. lactis. The recombinant variants rhCatG and rHNE, with intact C-terminal extensions, were expressed as fusion proteins with the …
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Induction of Interleukin-1(beta) Converting Enzyme in the Brain and Its Role in Anorexia Induced by Centrally Administered Lipopolysaccharide
… While ICV injection of neither ICE-like protease cathepsin G nor LPS alone reduced food intake in ICE-/- mice, in combination, however, cathepsin G restored the anorectic properties of central LPS in ICE-/- mice. Conversely, in WT mice the decrease in food intake caused by central LPS was entirely …
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Immunological responses following surgery in ulcerative colitis
… a variety of antigens, namely lactoferrin, cathepsin G, enolase and elastase. Confocal microscopy revealed maximum immunofluorescence for P-ANCA to emanate from the intranuclear and not the extra-(peri) nuclear portion of the neutrophil, as currently believed. AECA, like ANCA, are also found …
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Role of Type III TGF-β Receptor Shedding in Regulating Tumorigenesis
… have also demonstrated that cathepsin G and neutrophil elastase, proteases stored in the azurophil granules of neutrophils, can induce cleavage of cell surface TβRIII though no functional sTβRIII was detected. Similarly, activated neutrophils could induce TβRIII shedding on …
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Atypical Mechanisms of Synthesis, Activation and Release of Interleukin-1β from Vascular Smooth Muscle Cells
… protease inhibitor dichloroisocoumarin, with cathepsin G the most likely enzyme responsible for pro-IL-1β activation. Interestingly, mature IL-1β was never detected in the conditioned media and instead accumulated to high levels inside VSMCs. VSMCs expressed the pore-forming protein Gasdermin …
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Proteases of the neutrophil membrane represent an alternative fibrinolytic pathway to that mediated by plasmin
… of fibrin. Fibrinolysis by elastase and cathepsin G, enzymes present within the azurophilic granules of the neutrophil, has previously been shown. Recent studies have demonstrated neutrophil-mediated fibrinogenolysis by a membrane-associated protease which suggests that proteases …
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Characterisation of fibrinogen and fibrin proteolysis by the neutrophil membrane
… granule proteases, human neutrophil elastase, cathepsin G and possibly proteinase 3. Electron microscopy analysis of PMA stimulated neutrophils incorporated within fibrin clots revealed morphological changes suggestive of neutrophil degranulation, and the proteolytic activity released by these …
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The role of Moraxella catarrhalis outer membrane proteins in pathogenesis
Moraxella catarrhalis is an important respiratory pathogen. It is a common cause of otitis media in children, a usual infections agent in sinusitis and makes up to 10% of all exacerbations of chronic obstructive pulmonary disease (COPD). It is known to cause more frequent disease in the colder …