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Showing 1 to 20 of 41 for “"Cathepsin B"”.
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Production and characterization of monoclonal antibodies against cathepsin B and cathepsin B-Like proteins of Naegleria fowleri
… 주는 비접촉성 병인기작으로 알려져 있다. 파울러자유아메바의 시스테인 단백분해효소계열인 Cathepsin B (NfCPB) 및 Cathepsin B-Like (NfCPB-L) 단백질이 클로닝 되었고, 이들의 유전자 크기는 각각 1,038 bp (345개 아미노산) 및 939 bp (313개 아미노산)이다. 재조합 NfCPB와 NfCPB-L 단백질은 각각 38.4 kDa과 34 kDa의 분자량을 갖고 있으며, 숙주의 조직침투, 면역회피와 영양분흡수에 관련이 있다고 보고되었다. 본 연구는 파울러자유아메바에서 NfCPB와 …
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Independent predictors of executive function: Cathepsin B and strength
… blood draws to examine the molecule of interest, Cathepsin B (CTSB), maximal strength testing to assess isokinetic strength using a Biodex dynamometer (Biodex System 3, Shirley, NY), and a Spatial Reconstruction Task to assess relational memory. Attentional inhibition, a component of executive …
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Studies on cathepsin B of Eimeria tenella and pyroglutamyl peptidase of Leishmania major
A sequence encoding a cathepsin B-like cysteine peptidase of the clan CA, family C1 was identified in the genome database of E. tenella. The sequence corresponded to a single copy gene, and did not carry any introns. The E. tenella enzyme, sharing 42% identity with the Toxoplasma gondii toxopain-1, …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… the role of the lysosomal cysteine peptidase cathepsin B (CTSB) in tumour progression and metastasis, transgenic mice FVB/N-TgN(MMTVPyVT)634Mul, developing multifocal metastasising mammary carcinomas, were utilised. CTSB deficient mice, with a mixed C57BL/6J and 129SvJ background were made …
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Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
Naegleria fowleri, a free-living amoeba that is found in diverse environmental habitats, can cause an acute fulminating hemorrhagic meningoencephalitis, called primary amoebic meningoencephalitis (PAM) in experimental animals and in humans. Pathogenicity of N. fowleri may be induced by …
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Cathepsin B and D activity in various tissues and cultured cells from normal and dystrophic mice.
Dept. of Biological Sciences. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1982 .G665. Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.Sc.)--University of Windsor (Canada), 1982.
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Untersuchung zur Funktion von Cathepsin B in der durch zytotoxische T-Zellen vermittelten Lyse von Tumorzellen
… ihr eigenes Perforin mittels Expression von Cathepsin B auf der Zelloberfläche schützen. Interessanterweise wird Cathepsin B auch in vielen Tumorzellen vermehrt exprimiert und ist möglicherweise in die Tumorprogression involviert. Dies veranlasste uns zu untersuchen, ob Tumorzellen …
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Identification of Cathepsin B and L as Novel Uva Targets Upstream of Cutaneous Lysosomal-Autophagic Dysregulation
… the thiol-dependent cysteine-proteases cathepsin B and cathepsin L as novel UVA-targets undergoing photo-oxidative inactivation upstream of autophagic-lysosomal dysfunction. In human skin fibroblasts, exposure to noncytotoxic doses of chronic UVA (9.9 J/cm ², twice a week, 3 weeks) …
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Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer
… IN VITRO ANALYSES OF LIPID RAFT-ASSOCIATED CATHEPSIN B: IMPLICATION FOR THE INVASIVE PHENOTYPE </p> <p>OF INFLAMMATORY BREAST CANCER</p> <p>by</p> <p>BERNADETTE C. VICTOR</p> <p>December 2011</p> <p>Advisor: Dr. Bonnie F. Sloane</p> <p>Major: Cancer Biology </p> <p>Degree: Doctor of …
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Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
… involvement of the lysosomal cysteine proteases cathepsin-L and cathepsin-B in apoptosis pathways induced by distinct death stimuli, in particular by the tumor necrosis factor a (TNF-a). Therefore, both projects examine a possible regulation of apoptosis induction by proteases that are part of …
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Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma
… 6.8) affects the activity of proteases, such as cathepsin B, that contribute to degradation of collagen IV by tumor cells when grown in biologically relevant three-dimensional cultures. At pHe 6.8 there were increases in pericellular active cysteine cathepsins and in degradation of DQ-collagen …
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The role of proteases in development of cancer in mice
… and tumour tissues in mice. High activities of cathepsin B and B+L were found in tumour bearing tissues probably due to increased transcription of the cathepsin gene or stability of cathepsin B mRNA. Some malignant tissues secrete cathepsins which are thought to degrade the extracellular matrix. …
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Genetic determinants of cell sensitization to parvovirus H-1-induced activation of non-apoptotic death pathways
… in the cytosolic activation of lysosomal cathepsins B and L. The virus promotes efficient killing even in glioma cells overexpressing Bcl-2, an oncogene interfering with both apoptosis and autophagy induction. Besides, H-1PV-induced cathepsin B cytosolic activity is favoured by the …
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The Biological Basis for Toughness in Beef
… of desmin was concomitant with increasing cathepsin B activity in low pHu meat. It is hypothesised that meat tenderness is pHu compartmentalised by the variable degradation rates of myofibrillar proteins, which are in turn regulated by μ-calpain and cathepsin B activities. Intermediate pHu …
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Design and synthesis of indole-based analogues of OXi8006 as inhibitors of tubulin polymerization and their incorporation as payloads in drug-linker constructs.
… where the linker will undergo cleavage by cathepsin B, an enzyme overexpressed in many tumors, thus releasing the payload site-specific to the tumor. As a preliminary assessment of efficacy, KGP619, a drug linker construct incorporating the phenolic payload KGP555 and …
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Acute Pancreatitis. Studies on smoking and protease activation.
… studied in a rat model. Results and conclusions: Cathepsin B activated trypsinogen but not proelastase or procarboxypeptidase B. Hence, if cathepsin B is to play a role in the activation of digestive enzymes in acute pancreatitis, this probably occurs through activation of trypsinogen. The …
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Giardia trophozoite-secreted proteins and their effects on intestinal epithelia
… peptides, known virulence factors such as the Cathepsin B cysteine proteases and Variable Surface Proteins, scavenging proteins such as an extracellular nuclease and a high proportion of hitherto hypothetical proteins and proteins of unknown function. Further analysis of the genes encoding …
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Control of DAPK-1 degradation
… of DAPK-1. Here I identified the protease cathepsin B as a novel binding partner of DAPK-1 that protects DAPK-1 from TNF-α induced degradation. Using deletion mutants of DAPK-1, I mapped the cathepsin B binding domain on DAPK-1 to amino acids 836-947. Overexpression of this mini-protein …
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Development of nanoscale biosensors for cancer related proteases and blood-borne pathogens based on electrochemical and optical methods
… lithography show a much faster kinetics for cathepsin B proteolysis. This EC method was further applied in whole lysate of human breast tissue and breast cells. The detected protease activity was found increased in cancer cells, with the metastatic cancer cell lysate showing the highest …
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Influence of Human Papillomavirus 16 E6 on TRAIL-Mediated Apoptosis
… apoptosis in U2OS cells. However, analysis of cathepsin B activity in these cells revealed that it was significantly activated after exposure to TRAIL. Additionally, the cathepsin B inhibitor, CA074Me, inhibited TRAIL-mediated apoptosis and delayed the cleavage of Bid in U2OS cells exposed to …
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