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Showing 1 to 20 of 124 for “"Cathepsin"”.
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Production and characterization of monoclonal antibodies against cathepsin B and cathepsin B-Like proteins of Naegleria fowleri
… 주는 비접촉성 병인기작으로 알려져 있다. 파울러자유아메바의 시스테인 단백분해효소계열인 Cathepsin B (NfCPB) 및 Cathepsin B-Like (NfCPB-L) 단백질이 클로닝 되었고, 이들의 유전자 크기는 각각 1,038 bp (345개 아미노산) 및 939 bp (313개 아미노산)이다. 재조합 NfCPB와 NfCPB-L 단백질은 각각 38.4 kDa과 34 kDa의 분자량을 갖고 있으며, 숙주의 조직침투, 면역회피와 영양분흡수에 관련이 있다고 보고되었다. 본 연구는 파울러자유아메바에서 NfCPB와 …
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Functional Characterization of a Cathepsin L in Drosophila Melanogaster
… focused on understanding the role of a Cathepsin L like cysteine protease (CP1) in the development of dorsal ASP and wing development of Drosophila melanogaster. To analyze the function of CP1, we overexpressed and knocked down CP1, respectively, using UAS-GAL4 system in combination with …
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Dissecting the role of cathepsin V in breast cancer
… of new targeted therapeutic drugs. <br/><br/>Cathepsin V expression has been linked to many cancers including breast cancer. The expression of cathepsin V in breast cancer patients was found to be associated with distant metastasis; however, the regulatory function of cathepsin V has not been …
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Cathepsin S as a mediator of acute lung inflammation
… warrant investigation. The cysteine protease, cathepsin S (CTSS), is emerging as an influential mediator of pulmonary disease and may represent a novel target for the treatment of chronic and acute inflammatory lung conditions. <br/>In this thesis, we first evaluated the status of CTSS in the …
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Independent predictors of executive function: Cathepsin B and strength
… blood draws to examine the molecule of interest, Cathepsin B (CTSB), maximal strength testing to assess isokinetic strength using a Biodex dynamometer (Biodex System 3, Shirley, NY), and a Spatial Reconstruction Task to assess relational memory. Attentional inhibition, a component of executive …
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Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
… involvement of the lysosomal cysteine proteases cathepsin-L and cathepsin-B in apoptosis pathways induced by distinct death stimuli, in particular by the tumor necrosis factor a (TNF-a). Therefore, both projects examine a possible regulation of apoptosis induction by proteases that are part of …
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Cathepsin Z: Identifizierung und Charakterisierung einer neuen Cysteinpeptidase der Papainfamilie
Cathepsin Z konnte als neuer Vertreter der Papainfamilie C1A identifiziert werden. Im Mausorganismus kodiert die 1,4 kb umfassende Nukleotidsequenz für ein Polypeptid mit 306 Aminosäuren, beim Menschen setzt sich CTSZ aus 303 Aminosäuren zusammen. Die charakteristischen Merkmale einer …
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Inhibitors of human cathepsin L and cruzain as therapeutic agents.
Increased human cathepsin L activity is linked to invasive and metastatic cancers where it promotes degradation of the extracellular matrix. This major cysteine protease found in cell lysosomes and secreted from tissues, also plays a role in the pathology of degenerative cartilage and neurological …
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Isolation and characterization of cathepsin Z, a lysosomal cysteine proteinase
Cathepsin Z is a cysteine proteinase found in lysosomes of human cells. It was detected in human cultured cell lines using the peptidyl diazomethane inhibitor Fmoc-Leu-Leu- [¹²⁵]Tyr-CHN₂. The labeling of cathepsin Z by the inhibitor was both time- and concentration-dependent, and the proteinase was …
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Resveratrol Regulates IGF- II and Cathepsin D in Breast Cancer Cells
… cell modulation - i.e. apoptotie genes and Cathepsin D (CD), an estrogen-regulated protein elevated in breast cancer.</p> <p>RSV displays a biphasic effect on cell growth and IGF-II expression in ER+ breast carcinoma cells. In ER+ cells (MCF-7, T47D), RSV at 10<sup>-6</sup>M induces a 2-fold …
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Untersuchungen zur Pathogenese der dilatativen Kardiomyopathie in Cathepsin L-defizienten Mäusen
… die defizient für die lysosomale Cysteinprotease Cathepsin L sind, prägen in einem Alter von 12 Monaten eine DCM aus (Stypmann et al., 2002). Ziel der vorliegenden Arbeit ist, die Pathogenese der Kardiomyopathie der Cathepsin L-defizienten (ctsl-/-) Maus zu untersuchen. <br>Bereits im Alter von 3 …
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Cracking the code of cathepsin S: Structural determinants of specificity switching
Cathepsin S is a cysteine protease in the papain family that digests antigens as part of the adaptive immune response, activates receptors, and is associated with extracellular matrix degradation in autoimmune diseases and cancer. A comprehensive review of the literature revealed potential pH- and …
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Veränderungen in Proteom und Metabolismus bei dilatativer Kardiomyopathie Cathepsin L defizienter Mäuse
… Aspekten derdilatativen Kardiomyopathie bei Cathepsin L defizienten Mäusen konnten in dieserArbeit weiterführende Erkenntnisse über die Erkrankung gefunden werden. CTSLdefiziente Mäuse zeigen mit durchschnittlich mit 28,4g ein um 20% reduziertesKörpergewicht im Gegensatz zu gleich alten …
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Studies on cathepsin B of Eimeria tenella and pyroglutamyl peptidase of Leishmania major
A sequence encoding a cathepsin B-like cysteine peptidase of the clan CA, family C1 was identified in the genome database of E. tenella. The sequence corresponded to a single copy gene, and did not carry any introns. The E. tenella enzyme, sharing 42% identity with the Toxoplasma gondii toxopain-1, …
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Expression, Purification, and Characterization of the Mast Cell Proteases Chymase and Cathepsin G.
… and the serine proteases, tryptase, Chymase, and cathepsin G (CatG). These proteases are stored and released from mast-cell granules upon activation by antigen binding to IgE immunoglobulins on the cell surface or by direct injury. In this study, chymase and CatG were expressed as active enzymes …
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Compound discovery and expression of a putative cathepsin D-like protease in Trichomonas vaginalis
… hydrolase. Another potential target is a cathepsin D-like protease found in T. vaginalis . This aspartic protease in humans is responsible for degrading proteins in the lysosome, and degrading hemoglobin in P. falciparum as the homologue plasmepsin. Searching the gene database, only one …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… the role of the lysosomal cysteine peptidase cathepsin B (CTSB) in tumour progression and metastasis, transgenic mice FVB/N-TgN(MMTVPyVT)634Mul, developing multifocal metastasising mammary carcinomas, were utilised. CTSB deficient mice, with a mixed C57BL/6J and 129SvJ background were made …
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Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
Naegleria fowleri, a free-living amoeba that is found in diverse environmental habitats, can cause an acute fulminating hemorrhagic meningoencephalitis, called primary amoebic meningoencephalitis (PAM) in experimental animals and in humans. Pathogenicity of N. fowleri may be induced by …
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Cathepsin B and D activity in various tissues and cultured cells from normal and dystrophic mice.
Dept. of Biological Sciences. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1982 .G665. Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.Sc.)--University of Windsor (Canada), 1982.
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Untersuchung zur Funktion von Cathepsin B in der durch zytotoxische T-Zellen vermittelten Lyse von Tumorzellen
… ihr eigenes Perforin mittels Expression von Cathepsin B auf der Zelloberfläche schützen. Interessanterweise wird Cathepsin B auch in vielen Tumorzellen vermehrt exprimiert und ist möglicherweise in die Tumorprogression involviert. Dies veranlasste uns zu untersuchen, ob Tumorzellen …
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