Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Cathelicidin"”.
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The Potential Role of Cathelicidin Peptides for the Treatment of Lower Respiratory Tract Infections
… in the lung. It was hypothesized that a cathelicidin/exogenous surfactant compound could be developed as a novel therapeutic agent for the treatment of bacterial pneumonia. To test this hypothesis, we first screened several cathelicidin peptides combined with a commercial exogenous …
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Expression und Regulation des antimikrobiellen Cathelicidin-Peptids LL-37 in humanen Kolonepithelzellen, Monozyten und PBMC
… sind bisher zehn Defensine und das humane Cathelicidinpeptid LL-37 beschrieben worden. Letzteres war auch Gegenstand unserer Forschungen. LL-37 wird in den Granula von neutrophilen Granulozyten gespeichert und in Knochenmark und Hoden, sowie in Hautkeratinozyten, Lungenepithel, und …
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In vitro effects of different innate-immune stimulants on Chinook salmon embryo cell line (CHSE-214): transcriptional and translational studies
… infections. The expression of innate effectors: cathelicidin, hepcidin, iNOS, MDA5, RIG-I and ISG25 mRNA was assessed by qPCR in Chinook salmon cell line (CHSE-214) before and after treatment with potential inducers: ß-hydroxy-ß-methylbutyrate, 4-phenylbutyrate, 1,25(OH)2 D3, omega-3 and omega-3 …
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Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections
… single cell behavioral analysis revealed that cathelicidin initiated neutrophil swarming and clustering, which preceded LTB4 dependent immunothrombosis. These immunothrombi trapped bacteria and promoted platelet dependent microbial resistance but also caused lethal vascular occlusions. …
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Neutrophil localization during C. rodentium-induced colitis
… phase (7 dpi) and reach the colonic lumen. Cathelicidin, an antimicrobial peptide, deficiency leads to more neutrophil recruitment than its wildtype counterpart upon infection. Furthermore, the bulk RNA sequencing results show that NET formation and degranulation are upregulated neutrophil …
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Synthesis and solid state F-NMR studies on fluorine-labeled antimicrobial peptide RK-21
… outer membrane. LL-37 is the only member of the cathelicidin group of antimicrobial peptides present in humans and shows a broad range of antimicrobial activity. RK-21 is a fragment of human antimicrobial peptide LL-37, which is α-helical, cationic and amphipathic in nature. RK-21 displays …
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Proteomic Investigation of Salivary Biomarkers in Periodontal Diseases
… of human neutrophil peptide 1-3 (HNP 1-3), cathelicidin LL-37 and protein S100A8 were tested. Copy number variation for HNP 1-3 gene, DEFA1A3 was tested in an independent cohort and the data analysed for association with presence and degree of periodontal disease. -- Results: Antimicrobial …
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Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses
Cathelicidins are cationic host defence peptides (CHDP) with essential roles in the innate defence system. These peptides have antimicrobial potential and the capacity to modulate innate immunity and inflammatory processes. Neutrophils (PMN) are the main reservoir of cathelicidins and play key …
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A biosynthetic approach to the discovery of novel bioactive peptides
… tag was utilised to produce the model murine cathelicidin K2C18, along with a number of variants, which exhibited varying degrees of antimicrobial activity against a panel of microbes. Importantly, K2C18 also exhibited a bacteriostatic effect in vivo when secreted to the periplasm. This …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… reduced tryptase release in response to the Cathelicidin LL37. Furthermore, absence of GRK2 resulted in increased cutaneous vascular permeability in response to C48/80 in vivo. By contrast, LL37-injection induced rosacea-like erythema, generation of matrix metalloproteinase 9 (MMP9), …
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Expression of green fluorescent protein (GFP) in Leishmania spp. to identify survival strategies the parasite imposes on the human host
… including TNFα, IL-10, TGFβ, IL-1RA and cathelicidin at various time points during L. aethiopica infection. As cytokine expression is closely linked to manipulation of T-cells, which are also know to be ultimately responsible for disease exacerbation/resolution, the effect of the …
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Actions of Antimicrobial Peptides and Bacterial Components in Inflammation
… role is to protect us from infections. The human cathelicidin-derived antimicrobial peptide, LL-37, not only possesses broad spectrum antimicrobial activities but is also able to bind and neutralize bacterial lipopolysaccharide (LPS), an important trigger of the widespread inflammatory response …
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Fragments of the human antimicrobial LL-37 and their interaction with model membranes
… of LL-37, a human antimicrobial peptide from the cathelicidin family. The fragments LL-32 and LL-20 exhibited contrary behavior in biological experiments concerning their activity against bacterial cells, human cells and human cancer cells. LL-32 had even a higher activity than LL-37, while LL-20 …
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Effect of probiotics or high incubation temperature on gene expression and cell organization of the small intestine and yolk sac of chicks
… by probiotic supplements. Avian defensin and cathelicidin expression patterns in the YS were not affected by breed.
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Antimicrobial Effectors Act Cooperatively to Stress Salmonella in the Macrophage Phagosome
… SodCI is retained. Likewise, mouse macrophage Cathelicidin-related antimicrobial peptide (CRAMP) treatment leads to SodCII release, while SodCI is tethered within the periplasm. We tested if SodCII, protected from release by antimicrobial peptides, could contribute to virulence in vivo. A …
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Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications
… al., 2009). In addition, proteolytic cleavage of cathelicidin by KLK5 results in production of antimicrobial and proinflammatory peptides (Yamasaki et al., 2006). Interestingly, the KLK5-PAR2-NF-κB-TNFα signaling pathway is activated and triggers inflammation also in common inflammatory skin …