Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 253 for “"Catenin"”.
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Beta-catenin Complexes in Colorectal Cancer
… that is disrupted in colorectal cancer and β-catenin is the key mediator of Wnt signalling. β-catenin is a multifunctional protein with roles in Wnt signalling and cell adhesion. I aimed to understand the relationship between the main interactions and functions of β-catenin. Specifically, I …
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Developmental and Cellular Functions of Delta-Catenin
<p>Catenins have diverse and powerful roles in embryogenesis, homeostasis or disease progression, as best exemplified by the well-known beta-catenin. The less studied delta-catenin likewise contains a central Armadillo-domain. In common with other p120 sub-class members, it acts in a variety of …
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Mechanisms Regulating The P120-Catenin/Kaiso Pathway
… in cancer and developmental biology, with β-catenin being a key canonical component. P120-catenin, which is structurally similar to β-catenin, regulates the expression of certain Wnt target genes, relieving repression conferred by the POZ/ zinc-finger transcription factor Kaiso. In my first …
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Wnt/beta-Catenin-Zielgene in der Mausentwicklung
Der Wnt/beta-Catenin-Signalweg ist an der Steuerung vieler Prozesse während der Embryonalentwicklung beteiligt. Die zentrale Komponente des Signalwegs ist das Protein beta-Catenin, das an LEF/TCF-Transkriptionsfaktoren bindet und so Zielgene des Wnt/beta-Catenin-Signalwegs aktiviert. Ziel dieser …
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Wnt-/beta- Catenin Zielgene der frühen Mausentwicklung
… entwicklungsrelevante Zielgene der Wnt-/b- Catenin- Kaskade identifiziert. <br>Es wurde ein Zellkultursystem etabliert, mit dem es möglich war, unter einfachen experimentellen Bedingungen, die Wnt- Kaskade in Zellen induzieren zu können. Für das benutzte Zellkultursystem aus Embryonalen …
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Force-dependent changes in alpha-catenin conformation
… reinforce stressed intercellular contacts. α-Catenin is an identified force sensor within cadherin complexes. Mechanical force regulates binding of α-catenin to the actin-binding protein vinculin and to the actin cytoskeleton itself. This regulation is accomplished through distinct …
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Beta-Catenin and Development of the Urogenital System
… of the urogenital system, canonical Wnt/beta-catenin signaling is known to play a significant role. To better understand the role Wnt signaling plays in reproductive tract development, we conditionally removed beta-catenin from the Wolffian duct using a HoxB7cre line of mice. We determined …
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Structural Basis of Adhesion Activation of the Cadherin-Catenin Complex
… cytoplasmic tail. The tail is bound to alpha-catenin, beta-catenin, and p120-catenin, together known as the cadherin-catenin complex. Through alpha-catenin, the complex is connected to the cytoskeleton. Cadherins form adhesive bonds to neighboring cells through their extracellular domains. …
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Role of ß-catenin and Leukotriene in Colon Cancer Progression
… common cancer worldwide. Deregulation of Wnt/β-catenin signalling pathway is an early hallmark of colon cancer. Were nuclear accumulation of β-catenin is a marker of activated canonical Wnt/β-catenin signaling. One of the risk factors for development of colon cancer is inflammatory bowel …
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An immunohistochemical study of beta-catenin in HNPCC colon tumours
Beta-catenin is normally complexed with adenomatous polyposis coli (APC) protein and E-cadherin adhesion molecule, and localized on the cell membrane. If APC/beta-catenin is disrupted, beta-catenin transfers into the nucleus, where it functions as a transcriptional activator, causing unregulated …
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Prostate cancer stem cell fate: β-catenin and the Wnt pathway
… of tumour cells. Wnt activity and β-catenin signalling have been associated with different types of cancer and microarray data from our laboratory highlighted upregulation of members of the Wnt pathway in primary prostate cancer stem cells. Therefore, the aim of this study was to …
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A Novel Switch-Like Function of Delta-Catenin In Dendrite Development
… novel interactions involving the protein delta-catenin.</p> <p>In neurons, delta-catenin localizes to dendrites and synapses, where it functions in their development and maintenance. Structurally, delta-catenin possesses a central Armadillo domain and a C-terminal PDZ-binding motif. This motif …
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Defining the molecular basis for the β-catenin and CDC73 interaction
… Gene specific transcription factors, including β-catenin, a component of the Wnt signaling pathway, are used to regulate gene expression in response to developmental or environmental cues. Previous studies reported that β-catenin binds to the central region of CDC73, a subunit of the Polymerase …
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INVESTIGATING ALTERNATIVE SPLICING REPROGRAMMING REGULATED BY THE E-CADHERIN/B-CATENIN AXIS
… this dysregulation, pinpointing E-cadherin and β-catenin as central players in myosin VI AS regulation. β-catenin's nuclear translocation induces myosin VIshort expression, while its depletion rescues myosin VIlong. Furthermore, we uncovered β-catenin's broader involvement in AS oncogenic …
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DISSECTING THE ROLE OF Β-CATENIN AND MYC IN GASTRIC TUMOR FORMATION
… specification. Aberrant activation of the Wnt/β-catenin signaling pathway occurs in the vast majority of human gastrointestinal tumors. Despite it is well known that deregulation of Wnt signaling pathway is a clear genetic event driving the onset of intestinal tumors, its role in gastric …
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Understanding the Role of Delta-catenin in Virus-Positive Merkel Cell Carcinoma
… development. In Chapter 2, we identified delta-catenin as a novel ST interactor in HFFs. While ST bound delta-catenin in HFFs, this interaction was absent in virus-positive (VP)-MCC cell lines. We found that while HFFs predominantly express isoform 1, a mesenchymal marker, MCC cells primarily …
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P120-Catenin Regulates Rest and Corest, and Modulates Mouse Embryonic Stem Cell Differentiation
<p>The canonical-Wnt pathway and beta-catenin have been extensively studied to determine their contributions to stem cell biology, but less is known about p120-catenin in the nuclear compartment. P120 is developmentally required as a consequence of its biochemical and functional interactions with …
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AKR1B10 PROMOTES BREAST CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY
… BREAST CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY MAJOR PROFESSOR: Dr. Deliang Cao Aldo-keto reductase 1B10 (AKR1B10) is not expressed in normal breasts, but upregulated in primary and metastatic breast cancers, being a negative prognostic marker. This study …
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