Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Catechol-O-Methyltransferase (COMT)"”.
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COMT Genotype, Schizophrenia, and Dopamine Transmission
Catechol-o-methyltransferase (COMT) catabolism is the primary mechanism for dopamine signal deactivation in the dorsolateral prefrontal cortex, an area of the brain associated with working memory. Working memory deficits are found in persons with schizophrenia and their unaffected siblings. A …
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Estrogen and 2-methoxyestradiol: regulation of arthritis, inflammation and reactive oxygen species
… immune system. Both wild type (WT) mice and Catechol-O-methyltransferase (COMT)-deficient mice were used, as COMT metabolizes E2 into 2me2. Further, E2's regulatory role was investigated in WT mice or ROS-deficient mice (B10.Q.Ncf1*/*), in a model of osteoporosis and a local (LPS-induced) …
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The interactive effects of genetics and cardiorespiratory fitness level on cognitive performance in healthy older adults
… on cognition and its sensititvy to aging. The Catechol-O-Methyltransferase (COMT) and Dopmaine Beta Hydroxylase (DBH) genes were chosen because their protein products influence levels of dopamine within the brain. Further, each gene has two common functional single nucleotide polymorphisms …
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Looking Through the Lens of Individual Differences: Relationships Between Personality, Cognitive Control, Language Processing, and Genes
… level. We explored whether genetic variation in catechol-O-methyltransferase (COMT), a gene that regulates the catabolism of dopamine in prefrontal cortex, is related to individuals’ ability to resolve lexical and syntactic conflict. The results of this study demonstrated that individual …
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Sex steroid hormones - roles in adaptive immunity and vascular pathology
… This thesis aimed to 1) determine the role of catechol-O-methyltransferase (COMT) for the vasculo-protective actions of estradiol, 2) determine the role of the androgen receptor (AR) in the atheroprotection actions of testosterone, 3) investigate the role of the AR in neointimal hyperplasia, 4) …
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Toxicity of TCDD in the mouse antral follicle
… of TCDD and also in E2 catabolism to catecholestrogens and the highly reactive quinones, increased levels of Cyp1b1 could be an indication of a system under stress. Quinones are known to cause DNA damage, and if the DNA is left unrepaired, it can lead to mutations that propagate into …
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Estrogen sulfotransferase (sult1e1) expression and function in mcf10a-series breast epithelial cells: role as a modifier of breast carcinogenesis and regulation by proliferation state
… dehydrogenases (17βHSD1 and 2), CYP1B1, and catechol-O-methyltransferase (COMT) in an MCF10A-derived lineage cell culture model for basal-like human breast cancer progression and in ERα-positive luminal MCF7 breast cancer cells. Low levels of ERα and ERβ mRNA were present in MCF10A-derived …
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The impact of serotonergic and dopaminergic genetic variation on endophenotypes of emotional processing
… polymorphisms in genes encoding the enzyme catechol-O-methyltransferase (COMT) and the dopamine transporter (DAT), respectively, which both terminate dopamine signalling and are thus important regulators of dopaminergic neurotransmission, on the startle reflex in older adults. COMT met/met …
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Methamphetamine-induced neuroadaptations in the rat: Effects of adolescent use on the dopaminergic system and drug taking behaviors
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms