Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Catalytic subunits"”.
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Analysis of the functions of phosphoprotein phosphatase 1 catalytic subunits during cell division
… are holoenzymes composed of one of three catalytic subunits -α, β, and γ - in complex with one or two regulatory subunits. There is some evidence indicating that the three PP1 catalytic subunits might have distinct roles during cell division, but our knowledge of PP1-mediated …
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Towards understanding substrate recruitment by PP1 holophosphatases
… enzyme functions as a holoenzyme, with a core catalytic subunit (PP1c) bound to one or two non-catalytic subunits. These non-catalytic subunits have various proposed functions including inhibiting PP1c, aiding PP1 biogenesis, providing substrate specificity, and localising PP1c. Over 200 …
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Molecular Genetic Analysis of Non-Catalytic Pol IV and V Subunits
… and Pol II, IV and V still utilize multiple non-catalytic subunits encoded by the same genes. Genetic analysis of non-catalytic subunits that are highly similar reveals that these subunits are not necessarily redundant. For instance, NRPB9b but not its 97% similar paralog, NRPB9a is required for …
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Protein Kinase A Regulates Hyphal Growth by Relieving the Interaction of MoSfl1 with the Cyc8-Tup1 Co-repressor in Magnaporthe oryzae
… in M. oryzae named CPKA and CPK2 encode the catalytic subunits of cAMP-dependent protein kinase A. Previous studies have shown that deletion of CPKA failed to block response to exogenous cAMP, suggesting the involvement of CPK2 in cAMP signaling. To further characterize the function of the …
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Enforced Large-Scale Motions in Proteins
… Spontaneous motions of isolated ATP synthase catalytic subunits are also examined. The subunits, starting from different experimentally observed conformations, perform a combination of twisting and bending motions as they move toward a common conformation, which suggest specific mechanical …
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Blood coagulation reactions on nanoscale membrane surfaces
… protein complexes composed of regulatory and catalytic subunits. The biomembranes involved in these reactions not only provide a platform for these procoagulant proteins, but can also affect their function. Increased exposure of acidic phospholipids on the outer leaflet of the plasma membrane …
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ΦΩΣΦΟΡΥΛΙΩΣΗ ΠΡΩΤΕΙΝΩΝ ΣΕ ΣΥΣΤΗΜΑ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ ΕΛΕΥΘΕΡΟ ΚΥΤΤΑΡΩΝ ΑΠΟ ΣΥΚΩΤΙΠΟΝΤΙΚΟΥ. ΚΑΘΑΡΙΣΜΟΣ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΜΙΑΣ ΝΕΑΣ ΚΙΝΑΣΗΣ ΠΡΩΤΕΙΝΩΝ ΠΟΥ ΡΥΘΜΙΖΕΤΑΙ ΑΠΟ ΚΥΚΛΙΚΑ ΝΟΥΚΛΕΟΤΙΔΙΑ
… ENZYME IS NOT DISSOCIATED INTO REGULATORY AND CATALYTIC SUBUNITS, THIS NOVEL KINASE NAMED CYCLIC NUCLEOTIDE- REGULATED PROTEIN KINASE (NRPK).
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Cardiac Calsequestrin Phosphorylation And Trafficking In The Mammalian Cardiomyocyte
… of drug. SiRNA knockdown of both CK2α and CK2α′ catalytic subunits in nonmuscle cells reduced CSQ2 kinase activity by nearly 2-fold according to similar in vitro CSQ2 phosphorylation assays.</p> <p> </p> <p>Additionally, both ATP-binding site competitive inhibition and CK2 RNAi protein inhibition …
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Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis
… (FAD) in 1995. Subsequently characterized as the catalytic subunits of the γ-secretase protease complexes, the presenilins are responsible for the cleavage of the amyloid precursor protein (APP) and generation of amyloid beta (Aβ). To date, γ-secretase proteases have over 120 substrates which …
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A lentiviral screen for novel regulators of IL-7R[alpha] in a pre-B cell line
… I family of PI3Ks consists of four different catalytic subunits, which can pair with any of six different regulatory subunits. PI3K was recently shown to regulate the expression of the interleukin-7 receptor alpha chain (IL-7R[alpha][alpha]) via the Foxol transcription factor.
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The effect of hybridization on metabolism and hypoxia tolerance in sunfish
… between nuclear- and mitochondrial-encoded subunits of the enzyme complexes of oxidative phosphorylation. In my thesis, I examined metabolic properties and hypoxia tolerance of bluegill (Lepomis macrochirus), pumpkinseed (L. gibbosus), and their unidirectional F1 hybrids (male bluegill x …
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Mechanism of activation of photoreceptor phosphodiesterase by transducin and by low molecular weight proteins
… with two associated inhibitory gamma subunits, and is bound to the disk membrane by isoprenyl groups. Each catalytic subunit contains a catalytic site and a high-affinity cGMP binding site. In this research, two independent mechanisms of PDE regulation are addressed. The first part …
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Redox Regulation of Type Iα PKA in the Heart
The two regulatory RIα subunits of cAMP-dependent protein kinase (PKA) form interprotein disulfides during oxidative stress which is associated with kinase activation. PKA classical activation involves cAMP binding to the regulatory subunits causing release of catalytic subunits which phosphorylate …
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The Role of Protein Phosphatases in Regulation of Drosophila S6 Kinase by Nutrient Signaling Pathways
… of phosphatases and Drosophila PP2A regulatory subunits for effects upon nutrient signaling pathways. I have shown that the PP2A catalytic subunit is required for the dephosphorylation of Drosophila S6 kinase (dS6K) during periods of inhibition of growth. The ablation of two other gene products, …
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Investigating the isoform-specific role of phosphoinositide 3- kinase p110delta
… PI3Ks are heterodimers consisting of a ~110 kDa catalytic subunit associated with a regulatory subunit. Class I PI3Ks are further subdivided into class IA and class IB, which are activated downstream of tyrosine kinases or G protein-coupled receptors, respectively. The mammalian catalytic …
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EPIGENETIC MECHANISMS OF POLYCOMB REPRESSIVE COMPLEX 1 IN INTESTINAL LINEAGE COMMITMENT
… Polycomb repressive complex 2 (PRC2) with the catalytic subunit EZH1/2 which can mono, di, and tri- methylase the histone H3 at lysine 27 (H3K27); and Polycomb Repressive Complex 1 (PRC1) with the catalytic subunits RING1A/B, which catalyze the monoubiquitylation of histone H2A at lysine 119 …
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Role of the IKK complex during liver regeneration
… homeostasis. The IKK complex (composed by two catalytic subunits IKK1 and IKK2 and a regulatory subunit Nemo) tightly regulates NF-kB activity. In the present work, we modulated NF-kB activity in the liver by using hepatocyte-specific IKK2 (IKK2dhepa) and hepatocyte-specific Nemo (Nemodhepa) …
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Structure-Function Studies of the cAMP-Dependent Protein Kinase <i>In Vitro</i> and in Intact Cells
… study of kinases because it contains a conserved catalytic core shared with all eukaryotic kinases, it is the simplest kinase, and it is one of the best-characterized serine/threonine kinases. PKA is ubiquitous in mammals and regulates multiple physiological mechanisms such as the cell cycle, …
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Tumor necrosis factor induced oxidative stress in the central nervous system contributes to sympathoexcitation in heart failure
… was investigated on the expression of the catalytic subunits of NADPH oxidase (Noxs) in the PVN neurons and on the sympathetic activity in CHF rats. Additionally, effects of TNF inhibition on central nitric oxide were explored, as this ROS restrains sympathoexcitation. More specifically, …
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Assembly of nuclear dimers of the PI3K regulatory subunits underpins the proliferative activity of Activated Cdc42-associated Kinase, ACK
… of PI3K signalling, the PI3K regulatory subunits. ACK directly phosphorylates 4 out of the 5 isoforms (p85α, p55α, p50α, p85β) on a conserved tyrosine located on the iSH2 region (Tyr607 for p85α). Phosphorylation of p85β at this site was found to promote cell proliferation, yet …
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