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Showing 1 to 1 of 1 for “"Catalytic oligos"”.
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Development of synthetic RNA-targeting catalysts from biostable nucleic acid analogues
… (cG35A). Through re-selection, we enhanced its catalytic rate by four-fold (0.42 h⁻¹) and increased its maximum cleavage by 25% (cf. rate of KRAS transcript turnover is between 0.2 and 0.6 h⁻¹). We also characterised its capacity for allele-specific cleavage of long transcripts under …