Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Catalytic RNA"”.
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The reaction kinetics and three-dimensional architecture of a catalytic RNA
… promote a reaction similar to a single step in RNA polymerization: attack of a primer 3'-hydroxyl on a 5'-triphosphate, with formation of a new 3'-5' bond and release of pyrophosphate. Derivatives have been shown to catalyze general primer extension reactions, making the ligase a useful paradigm …
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DNA-catalyzed covalent modification of amino acid side chains in tethered and free peptide substrates
Scientists thought of RNA as passive messenger molecules until the discovery of catalytic RNA (ribozymes) in the 1980s, which revolutionized thinking toward the multifaceted functions of RNA. The discovery of catalytic RNA also sparked an intense interest in exploring the catalytic functions of …
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The RNA World: A Look at Ribonuclease P RNA, Small Nucleolar RNA, 6S RNA, and the Small Ribosomal Subunit
The term RNA world was first coined in 1986 by W. Gilbert. It was largely based on the observation that RNA, not protein, was responsible for the most critical roles in Bacteria, Archaea and Eukaryotes. Although the RNA world means different things to different researchers Gerald Joyce and Leslie …
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DNA target site recognition by the Ll.LtrB group II intron RNP
… particle (RNP) composed of excised intron RNA and an intron-encoded protein (IEP). The intron lariat inserts at a specific DNA target sequence and is then reverse transcribed by the IEP. Both the intron RNA and IEP are required for DNA target site recognition. I have identified the contact …
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Microbiology of periodontal disease in Singapore and the discovery of a bacterial intron in Actinobacillus actinomycetemcomitans
… gave similar results. In vitro transcribed cdt RNA catalyzed its own excision. The spliced products possessed different 5a?? exons but shared the same 3a?? exon with ribosome-binding site present upstream. Conservation of splice-site consensus sequence was important for accurate splicing. The …