Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"Caspases"”.
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Elucidating the role of effector caspases in immune development using lentiviral RNAi
Caspases play an important role in apoptosis, or programmed cell death. In particular, three highly related effector caspases, caspases-3, -6, and -7, translate upstream death signals into the physical manifestations of apoptosis by proteolytically cleaving structural and enzymatic targets. …
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Mechanisms of Controlled Proteolysis during Drosophila Spermatogenesis: Coordinate Action of Apoptotic Caspases and the Ubiquitin-Proteasome System
… between different cell types and paradigms. Caspases have also been shown to have non-apoptotic roles in many vital cellular processes, heightening the need for specific modulators. Therefore, exactly how caspases are regulated is still being worked out, and new factors are still being …
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Direct Regulation of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) and Feedback Regulation of Lubac Function By Caspases
… function of LUBAC from apoptosis. Effector caspases induce RNF31 cleavage in apoptotic condition, which suppresses its role in NF-kB activation. This study is the first to demonstrate the molecular mechanism of how LUBAC governs the apoptosis pathway via linear ubiquitination and a novel …
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Evolution des programmierten Zelltods
… simple metazoan Hydra does posses two genes for caspases: Caspase 3A and caspase 3B. We generated antibodies against these caspases. By immunofluorescence staining and cell fractionation we demonstrated that both caspases are localized in mitochondria in vivo.Caspase 3A is a constitutively active …
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Single-cell reporters for inflammatory caspase activity
Caspases are a 12-member family of human proteases that regulate apoptosis and inflammation. They serve as key effectors downstream of diverse signaling receptors and shape cell fate. Inflammatory caspases mediate the proteolytic processing of inflammatory cytokines and are essential in maintaining …
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IAP antagonist Grim mediates cell death through divergent pathways
… of cysteinyl aspartate-specific proteases (caspases), which in turn cause cell self-destruction. While caspases are activated upon various death stimuli or developmental cues, inhibitor of apoptosis (IAPs) can prevent caspase-mediated cell death, not only through direct binding and …
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Genetic analysis of programmed cell death in Drosophila melanogaster
… the execution of cell death is the activation of caspases, a conserved family of cysteine proteases. In Drosophila, the proteins, Reaper (Rpr), Head involution defective (Hid), and Grim, induce cell death via a mechanism that involves caspase activation. In order to further elucidate the …
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Une approche afin de produire les différentes conformations de caspase-7 tout en contrôlant l'induction de l'apoptose
… proteases that includes apoptotic initiators (caspases-8, -9 and -10) and executors (caspases-3, -6 and -7). During apoptosis, executioner caspases are cleaved by initiator caspases either by the extrinsic (death receptors) or by the intrinsic (mitochondrial) pathway of caspase activation. …
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Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer Cells
… (IAPs) regulates apoptosis by inhibiting caspases. This inhibition mechanism is an escape from death used by some human cancers. Second mitochondria-derived activator of caspases (Smac), a mitochondria-released protein during apoptosis, binds to IAPs BIR domains with four amino acid …
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The Intrinsic Caspase Death Pathway in Stroke Neurodegeneration
… disease onset. Cysteine-ASPartic proteASEs (caspases) are key mediators of apoptosis that are activated in distinct molecular pathways, but their impact in stroke is poorly defined. Direct evidence for caspase activation in stroke and the functional relevance of this activity has not been …
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Death by Frustration: How Defects in Cell Differentiation Trigger Apoptosis
… of its importance. A family of proteases called caspases brings about the orderly deconstruction of a cell through an evolutionarily-conserved process. A bewildering number of molecules have been implicated to either directly or indirectly regulate these enzymes. Since the net outcome between …
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Nanosecond Pulsed Electric Fields Induce a Mitochondria-Independent Apoptosis in B16F10 Melanoma Cells <i>In Vitro</i>
… inducing factor (AIF). Further examination of caspases with isozymes specific initiators indicated electric field-dependent increases in caspases -8 and interestingly -9 as well as executioner caspases -3, -6 and -7.</p> <p>NsPEFs activate signal transduction mechanisms that induce apoptosis …
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Immunotoxic Effects of Mixtures of Endosulfan and Permethrin Via Caspase Dependent Thymocyte Apoptosis
… pesticides regulate apoptosis in immune cells. Caspases are a family of cystine-dependent, aspartate-directed proteases that have an integral role in apoptotic cell death. Caspases, which are normally inactive in healthy cells, are activated during apoptosis and form an irreversible cascade. …
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Characterization of the vaccinia virus M1 protein on caspase inhibition and the MVA/5.2KB virus on immunogenicity
… caspase-9 activation, the inhibition of other caspases by M1 was also examined. Via expression of M1 in mammalian cells or yeast, M1 inhibited caspases-1, -2, -3, -5, -7 and -8 in addition to its inhibition of caspase-9. This suggests M1 is a broad-spectrum caspase inhibitor. Further studies …
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Small Molecule Modulation of Caspase Enzymatic Activity
… of the apoptotic signal are caspase enzymes. Caspases, a family of cysteine proteases, specifically cleave substrates C-terminal to an aspartic acid residue. Small molecule modulation of caspase activity can play an important role in the study of the apoptotic cascade, the role caspases have …
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Inflammasomes in the Intestinal Epithelium
… of pathological stimuli to activate inflammatory caspases, resulting in cell death and the release of IL-18 and IL-1. Inflammasomes are important in a wide range of diseases, in particular with auto-inflammatory disorders in humans. While they have been extensively studied in immune cells, their …
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Genetic control of death in Chinese Hamster Ovary cultures
… synthesized to protect cells from death. Caspases, a class of proteins found to be universally important in inducing apoptosis, were found to be activated in apoptotic CHO cells. Surprisingly, inhibition of caspase activity using z-VAD.fmk, a universal peptide inhibitor of caspases, failed …
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Biochemical Pathways in Apoptosis
Caspases are a family of proteases that once activated execute apoptosis, a cellular suicide pathway. Activated caspases have a unique property to cleave and activate themselves. Once the first caspase is activated, it generates a chain reaction resulting in robust caspase activity and rapid death. …
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