Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"Caspase-8"”.
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The Protumorigenic Role of Caspase-8 in Neuroblastoma
… of cancer-related deaths in pediatric patients. Caspase-8 (casp8), a proapoptotic protein, is silenced in approximately, 50-70% of neuroblastoma patient samples. Loss of casp8 has been suggested to increase NB metastasis and correlated, in some studies, with advanced-stage NB. Furthermore, …
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Resistenz gegenüber TRAIL-vermittelter Apoptose beim Ewing-Sarkom durch Caspase-8 Mangel - Modulation durch IFN-gamma-
… eine verminderte Expression von Caspase-8 gefunden. Diese war auch auf Proteinebene im Western Blot nachvollziehbar. Mittels IFN-gamma Behandlung ließen sich die beiden resistenten Zelllinien A4573 un JR gegenüber TRAIL-vermittelter Apoptose sensibilisieren. Als Ursache für dieses …
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A Study on a novel mammalian protein, FLASH, that is involved in the activation of caspase-8 during Fas-induced apoptosis
… FLASH, that is involved in the activation of caspase-8 during Fas-induced apoptosis」
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Loss of Caspase-8 Function In Combination With Smac Mimetic Treatment Sensitizes Head and Neck Squamous Carcinoma to Radiation Through Induction of Necroptosis.
<p>Caspase-8 (CASP8) is one of the most frequently mutated genes in Head and Neck Squamous Carcinomas (HNSCC), and mutations of CASP8 are associated with poor overall survival. The distribution of these mutations in HNSCC suggests that they are likely to be inactivating. Inhibition of CASP8 has …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… the intrinsic apoptosis pathway which involves caspase-9 activation as one of the initiating molecular events. However, our group recently found the new apoptotic pathways which are involved in 5-FU-induced apoptosisin which caspase-8 is an essential factor for 5-FU-induced cell death with …
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The role of cardiolipin in the regulation of mitochondria-dependent apoptosis
… family and results in the activation of the caspase cascade, leading to cell death. This event is considered as a point of no return in the apoptotic pathway and is often inhibited in cancer. Cardiolipin (CL) is a mitochondria-specific phospholipid that contains four acyl-chains. CL has been …
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A Non-Canonical Function for NLRP3 and AIM2 in Kidney Diseases
… cytokine maturation and pyroptosis via ASC and caspase-1 activation. Emerging studies demonstrate that NLRP3 or AIM2 is expressed in non-haematopoietic cells such as tubular epithelial cells (TEC) in the kidney. The central hypothesis of this thesis is that NLRP3 and AIM2 regulate host response …
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NLRP3 in Renal Injury and Inflammation
… the components of the inflammasome including caspase-1 and its substrate IL-1β. Rather, Nlrp3 primarily regulated caspase-8 activation and apoptosis in these cells. Experiments to elucidate the mechanism of Nlrp3- regulated caspase-8 activation and apoptosis suggested the involvement of Asc, …
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Small Molecule Inhibitors of HPV16 E6
… of several apoptotic proteins, including caspase 8 and p53. We proposed that blocking the interactions between HPV E6 and its partners using small molecules had the potential to re-sensitize HPV+ cells to apoptosis. To test this prediction, we screened libraries of small molecules for …
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Untersuchungen zur Signaltransduktion Ajoen-induzierter Apoptose in Leukämiezellen
… verursacht in HL-60 Zellen die Aktivierung der Caspase-3 sowie der Caspase-8. Eine generelle Aktivierung von Caspasen ist für die Ajoen-induzierte Apoptose nötig, da der Breitbandcaspaseinhibitor z-VAD-fmk die durch Ajoen provozierte DNA-Fragmentation völlig verhindert. 2) Die Ajoen-induzierte …
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Delineating mechanisms which underlie differential cell fates induced by p53 activation and HDAC inhibition in colorectal cancer
… most notably included the only known pseudo-caspase and cell death regulatory protein, FLIPL. <br/><br/>The work presented in this thesis builds upon these previous observations and delves into the complex mechanisms and pathways responsible for the synergistic induction of cell death …
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Biochemical and Molecular Characterisation of the FADDosome
… cell death pathway, which requires activation of caspase-9. However, our group has recently discovered that 5-FU-induced cell death is initiated by activation of caspase-8, whereas caspase-9 was found to be dispensable for this process. Moreover, our group has found that upon treatment with 5-FU, …
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Analysis of a novel cytotoxic drug induced TRAIL-R2 signalling complex using a new FACS-based Smac/DIABLO release assay
… It involves a new death receptor-independent caspase-8 inducing complex and modulation by the TRAIL-R2 (DR5). The DR5 modulation appears to be mediated by JNK activation, up regulation of a phosphatase and subsequent dephosphorylation of Bid. Dephosphorylated Bid can be cleaved by active …
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The role of c-FLIP in regulating resistance to ionizing radiation
… improve therapeutic outcomes. FLIP, anendogenous caspase-8 inhibitor is a critical regulator of cell death that is frequently overexpressed in various cancers. FLIP overexpression in cancer contributes to resistance to death receptor- and chemotherapy- induced cell death. Thus, this Thesis …
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Degenerative mechanism in dopaminergic neurons
… as chromatin condensation were evident. However, caspase-3 did not appear to mediate cell death upon MPP+ challenge in this cell line, therefore rejecting the widely accepted hypothesis that the mitochondrial-mediated pathway is involved. Instead, the use of specific caspase inhibitors showed data …
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Mechanismen der Inhibierung von Wirtszellapoptose durch <i>Toxoplasma gondii</i>
… die Fas/CD95-vermittelte Aktivität von Caspase 8, -9 und 3/7 sowie die Spaltung von Bid. Die Ligation von Fas/CD95 führte zu einer starken Aktivierung des intrinsischen Apoptosesignalweges, wie anhand der Cytochrom c-Freisetzung aus den Mitochondrien und einer deutlichen Aktivierung der …
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
… tandem death effector domains, homologous to procaspase-8. FLIP preferentially binds to FADD via its DEDs, inhibiting the recruitment and processing of procaspase-8 to its active form. Normal cells are resistant to loss of FLIP, but cancer cells are not. Targeting FLIP in cancer is an attractive …
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Antiproliferative activities of Euphorbia bicolor (euphorbiaceae) and Maclura pomifera (moraceae) extracts on estrogen receptor-positive and triple-negative breast cancer cell lines
… mechanisms. Key apoptotic markers such as caspase 3, caspase 8, caspase 9, FADD, FAS, ATF4, and CHOP were upregulated, while antiapoptotic BCL-2 expression was downregulated. Notably, the female extract also inhibited the PI3K/AKT pathway by reducing AKT and pAKT protein levels. Euphorbia …
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Die Rolle der Phosphorylierung von FADD/MORT1
… von CD95 kaum endogenes FADD und keine Caspase-8 gefunden werden konnte, waren bei C-FADD S194E endogenes FADD und Caspase-8 schon mit dem unstimulierten Rezeptor assoziiert. Untersuchungen mit den Transfektanten zeigten, daß C-FADD Wildtyp und S194E in der Lage sind, mit Aktin zu …
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Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… that MUC13 expression blocks the activation of caspase-8 and Bid in PanCa cells in response to TRAIL treatment. Further investigation showed that alpha and beta domains of MUC13 are indispensable for blocking caspase-8 activation and PARP cleavage, indicating that the MUC13 blocks TRAIL-induced …
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