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Showing 1 to 20 of 295 for “"Caspase-3"”.

  1. Is It Memory or Is It Death? Caspase-3 and Memory Formation

    Huesmann, Graham RowellUniversity of Illinois at Urbana-Champaign2015

    "Caspase-3 is a protease associated with development, cancer defense, and various disease states including Stroke, Alzheimer's and Parkinson's. Activation of caspase-3 is normally thought of as the terminal step in the biochemical cascade of apoptosis (programmed cell death). However, it is present …

    uiuc Repository record

  2. Methodische Evaluierung der imunhistochemischen Detektion aktivierter Caspase-3 im Hippokampus als Apoptoseparameter nach inkompletter zerebraler Ischämie bei der Ratte

    Matz, SusanneLudwig-Maximilians-Universität

    lmu-germany Repository record

  3. Vesicular stomatitis virus infection: requirement of caspase-3 activation for the efficient induction of apoptosis but not viral replications

    Hobbs, Jacqueline A.1999

    This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

    iupui Repository record

  4. Pengaruh ekstrak etanol akar widuri (Calotropis gigantea L.) terhadap kadar IFN-y dan ekspresi caspase 3 pada fibrosarcoma mencit (Mus musculus L.)

    Setiawan, AndriUniversitas Islam Negeri Maulana Malik Ibrahim2015

    … (Calotropis gigantea L.) terhadap kadar IFN-γ, Caspase 3 dan rata-rata berat badan pada fibrosarcoma mencit (Mus musculus L.) akibat induksi 7,12-Dimetilbenz(α) Antrasena (DMBA). Penelitian ini merupakan penelitian eksperimental menggunakan Rancangan Acak Lengkap (RAL) dengan 6 perlakuan 5 …

    malang Repository record

  5. THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN INCREASES P34CDC2 PHOSPHORYLATION AND ENHANCES CELL SURVIVAL AND PROLIFERATION BY PROTECTING THE WEE1 KINASE FROM DEGRADATION BY CASPASE-3

    Guzman, Javier Rivera2009

    … alone. Treatment of control BaF3 cells with the caspase-3 inhibitor Ac-DEVD-CHO increased both Cdc2-Tyr15 phosphorylation and Wee1 protein levels. In a similar fashion over-expression of wt-Survivin in these cells maintained high levels of Tyr15 phosphorylated Cdc2 and Wee1 protein. In MCF7 human …

    iupui Repository record

  6. Treatment of Ischemia Reperfusion Injury with RNA Interference

    Zwiep, Terry MThe University of Western Ontario2015

    … of this research was to determine the effect of caspase-3, complement 3, and RelB gene silencing in the reduction of IRI using an in vitro model. LLC-PK1 cells were used along with antimycin A for the in vitro IRI model. Prior to exposure to antimycin A, cells were transfected with caspase-3, C3, …

    uwo Repository record

  7. Formation of caspase activating complexes and activation of caspase-12 during apoptosis in AKR-2B mouse fibroblasts

    Kilic, MehtapUniversität Würzburg

    … Enzym hatte typische Eigenschaften von Effektor-Caspasen, wie die der Caspase-3, besaß jedoch einen ungewöhnlich hohen KM Wert von 100 µM, und die Molmasse der großen Untereinheit betrug 19 kDa anstelle der erwarteten 17 kDa. Mit Hilfe des rekombinanten mCaspase-3 Proteins wurde dieses Enzym in …

    wurz-thes Repository record

  8. Die Wirkungen von Peroxisomenproliferatoren auf primäre Hepatocyten aus der Regenbogenforelle (Oncorhynchus mykiss) und die permanente Fischzelllinie RTG-2 aus der Gonade der Regenbogenforelle

    Berbner, ThomasUniversität Heidelberg

    … Versuche beinhalteten den Nachweis von Caspase 3 und p53 durch Westernblotting sowie das Auftreten einer Verlagerung von Cytochrom c aus den Mitochondrien in das Cytosol. Ferner wurde die Spaltung eines Caspase 3-Substrats in clo-fibratbelasteten Hepatocyten untersucht. Ein Caspase …

    heid-diss Repository record

  9. Identification of Apoptotic Regulators in the Cervix of Pregnant Mice in Association with Cervical Softening

    양, 성천2011

    … And then the expressions of the Bcl-2, Bax, Caspase-3, Caspase-6 were analyzed. Stromal arrangements associated with apoptosis were assessed. Apoptosis is detected significantly during late pregnancy by TUNEL. On Western blotting; Expression of Bcl-2 was decreased progressively during …

    ajou Repository record

  10. Investigating the functional roles of the viral frameshift protein 2B* in EMCV infection

    Nguyen, SamanthaUniversity of Cambridge2024

    … and immunoblotting identified an increase in caspase-3 activation and gasdermin E (GSDME) cleavage in WT EMCV-infected samples relative to infection with 2B\*KO EMCV prior to 24 hpi. Work with caspase KO cell lines confirmed that EMCV-induced rapid cell lysis is supported by caspase-3 but that …

    cambridge Repository record

  11. Mechanismen der Apoptose in proximalen Tubulusepithelzellen der Niere (LLC-PK1) : ein pathophysiologisches Modell für das hämolytisch-urämische Syndrom (HUS)

    Nowack, Klaus

    … (0,1µg/ml) nachgewiesen werden. Die Messung der Caspase-3-Aktivität mit fluorometrisch markiertem Caspase-3-Substrat ergab eine Aktivierung der „Effektor“-Caspase-3 durch Shigatoxin1 und 2. Nach Inkubation mit beiden Shigatoxinen führte eine gleichzeitige Behandlung mit Disulfiram …

    freiburg-diss Repository record

  12. The Characterization of Osteocyte Apoptosis in a Mouse Model of Orthodontic Tooth Movement

    Moin, Sogole S2013

    … Apoptosis was detected by TUNEL assay and caspase-3 and RipK-1 were detected by immunostaining on histological sections.</p> <p>Results: The ratio of TUNEL-positive osteocytes was increased on the compression side at 12 hours and, to a lesser extent, 3 days. There was a trend for increased …

    uconn-diss Repository record

  13. Die Rolle des Proteins DEDD in Apoptose

    Schickling, OlafUniversität Heidelberg

    … inhibiert. Zudem aktiviert DEDD spezifisch Caspase-6 im Nukleus und kolokalisiert dort mit der aktiven Form des Enzyms. DEDD benötigt eine funktionelle DED, um pro-apoptotisch zu wirken, sich im Nukleolus anzureichern und Caspase-6 im Nukleus bzw. Nukleolus zu aktivieren. Im Zellkern …

    heid-diss Repository record

  14. Apoptotic markers in ejaculated human spermatozoa

    Brooks, Nicole LisaUniversity of the Western Cape2005

    … APO-Direct to identify DNA fragmentation, caspase-3 to detect expression of this active protease during early apoptosis and Fas expression. For the Annexin-V and caspase-3 assays, statistically significant differences (P<0.05) were evident between the three groups. No significant …

    western-cape Repository record

  15. Einfluss der Anästhetika Sevofluran und Propofol auf den nekrotischen und den apoptotischen Zelltod nach inkompletter zerebraler Hemisphärenischämie und Reperfusion in der Ratte über einen Beobachtungszeitraum von 28 Tagen

    Kellermann, KristineLudwig-Maximilians-Universität

    … was used to detect activated caspase-3 as a marker of apoptotic cell death. To distinguish activated caspase-3-positive neurons from other cells, a double staining, using the specific neuronal marker NeuN was used additionally. The results showed that with the exception of one …

    lmu-germany Repository record

  16. Procaspase-3 activation as a strategy to overcome resistance to targeted anticancer therapies

    Peh, JessieUniversity of Illinois at Urbana-Champaign2018

    … of apoptotic cell death by the executioner caspase (caspase-3). Paradoxically, the zymogen of the executioner caspase, procaspase-3, rather than being downregulated in cancer, has been found to be overexpressed in many cancers. In Chapter 1, I will describe the list of cancers that …

    uiuc Repository record

  17. Efeito da despolarização da membrana plasmática na modulação da apoptose de neutrófilos mediada por lipopolissacarídeo

    SPENCER NETTO, Fernando Antonio CampeloUniversidade Federal de Pernambuco2003

    … de cálcio ou ouabaína na apoptose e expressão da Caspase-3 em neutrófilos (PMN). MÉTODOS: PMN foram isolados de sangue de voluntários por gradiente de densidade e cultivados por 18h em meios com concentração normal (1.8mM) ou baixa de cálcio (<10nM), ou com ouabaína (1mM), um inibidor da …

    brazil-ufpe Repository record

  18. Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells

    Dover, Ellen NicoleWake Forest University2015

    … imaging analysis and apoptotic endpoint assays (caspase 3/7). ERα46 expression resulted in increased transcriptional and caspase 3/7 activity similar to ERα66. Interestingly, in all assays ERα46 was more sensitive to ligand treatment than ERα66, suggesting an inherent difference in the ligand …

    wfu Repository record

  19. EpitopeAnalysisofCytokeratin 18Protein binding withAutoantibodiesin SeraofPatientswith NonallergicAsthma.

    김, 정은2011

    … protein. We cleaved human recombinant CK18 with caspase-3 and caspase-6 which are involved in apoptosis process. To evaluate the fragment of CK18 binding with autoantibodies of sera from patients with nonallergic asthma, immunoblot was done. RESULTS: When the CK18 protein was treated by …

    ajou Repository record

  20. Heat shock protein 27 inhibition of the caspase cascade in human breast cancer cells

    Stafford, Lewis Joe

    … be released from the mitochondria initiating the caspase cascade. When there is an over-expression of Heat Shock Protein 27 (HSP27), the cell does not obey the death signals that it receives. In this study, the molecular mechanism for the HSP 27 inhibition of the caspase cascade is described in …

    unlv Repository record

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