Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Caspase-1"”.
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ROLE OF CKD AND CASPASE-1 IN NEOINTIMAL HYPERPLASIA DEVELOPMENT
… genes. Recent research indicates that Caspase-1 (casp-1) activation plays an essential role in sensing metabolic danger signal-associated molecular patterns and initiating vascular inflammation. Carbamylated LDL, a uremic toxin that has been shown to be found in higher levels in …
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Entamoeba histolytica-Induced Caspase-4 Activation Regulates IL-1β Secretion Through Caspase-1
… EhCP-A5 ligates α5β1 integrin to activate caspase-1 in a complex known as the NLRP3 inflammasome. In this study, we investigated the parasite requirements underlying macrophage caspase-4 and -1 activation and the role caspase-4 play in augmenting pro-inflammatory cytokine responses. …
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The role of amygdala-based caspase-1 activation in regulating the behavioral response to allostatic stress
… 24 h fasting in mice reduces the activity of caspase-1 in whole brain and in the prefrontal cortex, amygdala, hippocampus, and hypothalamus by 35%, 25%, 40%, 40%, and 40% respectively. A 24 h fast also results in a 40% reduction in anxiety-like behavior and a 21% and 31% increase in novel …
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The role of caspase-1 in liver and adipose tissue during metabolic dysregulation in mouse models on NASH
… of investigation. In this thesis, the role of caspase-1, a pro-inflammatory protease, is explored in murine models of diet-induced NASH. Caspase-1 expression and activation is increased after both MCD and high fat diets, and was detected in hepatocyte and non-parenchymal cells. However, after …
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Extracellular adenosine as a novel neuroimmune modulator
… receptor 1 knock-out mice. Importantly, when the caspase-1 inhibitor, YVAD-CMK, was administered by intracerebroventricular (i.c.v.) injection into the brain, post-hypoxia learning recovered in 4 hrs. Similarly, the administration of the adenosine receptor (AR) antagonist, caffeine, expedited …
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Inflammasome activation in THP-1 target cells triggered by pathogenic Naegleria fowleri
… By western blotting and ELISA analysis, the caspase-1 activation and IL-1β production from THP-1 cells and the culture supernatant were observed 3 hr after co-cultivation. In addition, the increased expression of ASC and NLRP3, which consist of inflammasome complex, was also observed 3 hr …
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Molecular Mechanisms Involved in Interleukin-1β Release by Macrophages Exposed to Metal Ions from Implantable Biomaterials
… for interleukin(IL)-1β production through caspase-1. Furthermore, these ions are known to induce oxidative stress, and inflammasome priming is known to involve nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling. However, the mechanisms of inflammasome …
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Investigating the Contribution of the Inflammasome to Persistent Pain States
… IL-1β is the cleavage of pro-IL-1β by active caspase-1, generating mature IL-1β. Activation of this enzyme requires assembly of the inflammasome, a multi-protein complex. The active complex contains a central scaffold protein (eg nod-like receptor-1 (NLRP1), NLRP3), the adaptor protein …
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Expression of inflammasome-related molecules from U87MG cells cocultured with Naegleria fowleri in the non-contact system
… protein, ASC, which in turn interacts with caspase-1 leading to its activation. Consequently caspase-1 promotes the maturation of the proinflammatory cytokines such as, interleukin IL-1β and IL-18. Inflammasome activation is crucial for host defense to pathogens, but recent studies have also …
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Caspase isoforms in inflammasome activation
… NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the pro-inflammatory cytokines pro-IL-1β and pro- IL-18 to their active form and cleavage of …
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Hypoxic immunomodulation results in increased disease risk and altered behavior via non-canonical pathways
… of reoxygenation, mice showed 65% increased caspase-1 activity in the amygdala by ICV-IHC determination with no significant changes observed within the hippocampus. To determine the extent of inflammasome activation in hypoxia/reoxygenation injury, drugs targeting potential activators such as …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
… cytosolic protein complexes that activate caspase-1 leading to cleavage of pro-IL-1β/pro-IL-18, and pyroptosis, a pro-inflammatory cell death program. Although microbial recognition by Toll-like receptors (TLR) induces synthesis of pro-IL-1β and pro-IL-18, its role in inflammasome …
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Entamoeba histolytica-induced Activation of Caspase-4 Regulates Gasdermin D Cleavage to Mediate IL-1β Secretion in Macrophages
… Eh in direct contact with macrophages activates caspase-1 by the assembly of the NLRP3 inflammasome complex in a Gal-lectin and EhCP-A5-dependent manner, resulting in the maturation and secretion of IL-1β and IL-18. Pyroptosis, an inflammatory mode of lytic programmed cell death, is essential for …
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Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomes
… signalling complexes vital in the activation of caspase-1, inflammation and wound healing. The dysregulation of inflammasome activity has been linked to the development of autoinflammatory diseases. Recently, the role of post-translational modifications has been identified to play an important …
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Regulation of TNF-alpha gene expression by TNFAIP1 as an activator or suppressor in response to lipopolysaccharide
… without the PMA treatment. 4. TNFAIP1 induces Caspase 1 gene expression in macrophages. 5. Caspase 1 induced by TNFAIP1 functions downregulation of TNF-alpha via p73. CONCLUSIONS: 1. MAP kinase, JAK, or PI3K, may be involved in TNF-α gene expression in LPS-dependent pathway. 2. TNFAIP1 …
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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection
… 2 (AIM2) forms an inflammasome with ASC and caspase-1 upon recognition of double-stranded DNA (dsDNA) in the cytosol leading to caspase-1 activation and caspase-1-dependent pyroptosis and release of cytokines IL-1 and IL-18. Mutations in AIM2 are frequently identified in patients with …
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Molecular basis of NAIP/NLRC4 inflammasome activation by flagellin
… the cytosolic NLR receptors, ASC adaptor and caspase-1 in response to pathogen- associated molecules or danger-associated signals. The NAIP/NLRC4 inflammasome is activated by the S. enterica flagellar filament protein (FliC), the SPI-1 type III secretion system needle (PrgI) and inner rod …
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Mechanisms of Innate Immune Dysfunction During Mycobacterium tuberculosis and HIV Co-infection
… cellular host of both Mtb and HIV, leads to a caspase-1 dependent increase in IL-1β secretion and cell death in vitro. To target the inflammasome pathway for host-directed therapy, the selective caspase-1 inhibitor, VX-765, was used. VX-765 treatment diminished caspase-1 enzyme activity within …
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Part A: Studies Towards Total Synthesis of an Anticancer and Antifungal Natural Product, Pseudolaric Acid B; Part B: Synthesis and Biological Evaluation of Berkeleyamide a and Its Derivatives
… converting enzyme (ICE), also known as caspase-1, responsible for the cleavage and activation of interleukin-1? (IL-1?) to its active form (17K), is involved in the pathogenesis of several auto immune inflammatory disorders. Subsequent research over the years suggests that ICE plays a …
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Visualisation of innate immune signalling complexes in cells by cryo-electron tomography
… of adaptor protein ASC into large puncta. Caspase-1 is recruited and then cleaved to initiate caspase-1 dependent pyroptosis and the release of pro-inflammatory cytokines. Previous structural studies have shown mechanistic models of the signalling components involved. However, the structure …
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