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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Casein kinase"”.
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Casein Kinase I Transduces WNT Signals
… Xenopus embryos. This assay identified a protein kinase, casein kinase I (CKI), as a novel component of the Wnt signaling pathway. We first showed that expression of CKI produces Wnt phenotypes. First, CKI induced completely formed second axes, or Siamese twins, when injected into embryos. Second, …
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Casein-Kinase-2-Beta und neuronale Entwicklungsprozesse
… als eine durch Transposon- Insertion in den Casein-Kinase-2ß-Genlokus verursachte, hypomorphe Mutation identifiziert, die zu einer starken Verringerung der Anzahl der die Pilzkörper bildenden intrinsischen Neurone führt. Eine Reversion des mbuP1-Pilzkörperphänotyps konnte unter anderem durch …
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Palmitoylation and the yeast casein kinase yck2
… In the yeast Saccharomyces cerevisiae, the casein kinase Yck2 is palmitoylated twice at its two C-terminal palmitoyl-accepting cysteine residues, by the palmitoyl-transferring enzyme Akr1. Once palmitoylated, Yck2 traffics through the well characterized secretory pathway to the plasma …
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Development of novel lysine targeting covalent inhibitors for Bruton’s tyrosine kinase and casein kinase 2 and synthesis of novel hybrid androgen receptor inhibitors
Cancer is the lead cause of death worldwide, accounting for 10 million deaths in 2020, or 1 in 6 deaths. While current therapies have significantly advanced in the last decade, they suffer from severe limitations such as resistance, lack of selectivity and life-threatening side effects. Herein we …
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ΑΠΟΜΟΝΩΣΗ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΤΗΣ ΚΙΝΑΣΗΣ ΚΑΖΕΙΝΗΣ ΙΙ ΑΠΟ ΣΠΛΗΝΑ ΠΑΙΔΙΩΝ ΜΕ ΜΕΣΟΓΕΙΑΚΗ ΑΝΑΙΜΙΑ
IN THE PRESENT STUDY CASEIN KINASE II WAS PURIFIED FROM CHILDREN'S SPLEEN, SUFFERING FROM BETA-THALASSEMIA MAJOR AND WAS CHARACTERIZED SDS POLYACRYLAMIDE GEL ELECTROPHORESIS AND ISOELECTRIC FOCUSING HAVE PROVED THAT THE ENZYME WAS HIGHLY PURIFIED. THE PURIFICATION STEPS INCLUDED ION EXCHANGE …
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TGA2 dual activity: N-terminus regulation of reversible DNA binding influenced by NPRI and CK2
… of the TGA2 bZIP domain when phosphorylated by Casein Kinase II (CK2). The mechanisms involved for directing a switch from basal repressor to activator, and the role of kinase activity, have not previously been looked at in detail. This study provides evidence for the involvement of a CK2-like …
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Novel Prognostic Markers and Therapeutic Targets for Glioblastoma
… in glioblastoma cells we found a list of 20 kinases that can be considered glioblastoma survival kinases. These survival kinases which we term as survival kinase genes, (SKGs) were investigated to find prognostic markers as well as therapeutic targets for glioblastoma. Analyzing these …
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Identifikation des Transportproteins PACS-1 als Nephrocystin-interagierendes Protein
… im Acidic Cluster. Phosphorylierung durch Casein Kinase 2 vermittelt und Dephosphorylierung hemmt die Interaktion mit PACS-1. Unsere Befunde legen nahe, dass PACS-1 an der Rekrutierung des Nephrocystin-Proteinkomplexes in das Trans-Golgi-Network, die Sortierstation der Zelle, beteiligt ist. …
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Genetic and Biochemical Studies on Protein Phosphorylation in the Circadian Clock of Drosophila Melanogaster
… This study investigates the role of the protein kinase Doubletime, a Drosophila ortholog of casein kinase Is, in the fruit fly circadian clock. For the first time enzymatically active Doubletime protein is produced and direct phosphorylation of clock protein Period is demonstrated. …
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Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc
… In this study, we identified c-Met, a tyrosine kinase, phosphorylates PARP1 at Y907 and that the phosphorylation increases PARP1 activity, thereby rendering cancer cells resistant to PARPi. The combination of c-Met inhibitors (METi) and PARPi has a synergistic effect for c-Met overexpressed TNBC …
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Biochemical and Structural Studies of the Role of FKBP(L)s in the fly and Mammalian Circadian Cycle
… homologues FKBP51, FKBP52 and FKBPL. In vitro kinase assays showed that all three proteins stimulate CK1δ phosphorylation activity towards casein. Among these three proteins, FKBP51 was seen to bind mammalian casein kinase 1 delta (CK1δ) with much stronger affinity than the other FKBPs. From …
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Protein kinases that phosphorylate 14-3-3 isoforms
… of S233 by the serine /threonine protein kinase Casein kinase la (CK1 a) was shown to negatively affect the interaction with Raf kinase. The group of Gotoh have recently shown that phosphorylation of S185 by the stress activated kinase c -Jun NH2- terminal kinase (JNK) negatively effects …
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Direct conversion of chemical energy to mechanical work using a phosphate charged protein
… research, we use a phosphate charged protein, casein, and react it with divinyl sulfone (DVS) through a Michael addition reaction to produce a cross-linked gel. The protein gel could be ephosphorylated at standard conditions using bovine phosphatase (bp) and re-phosporylated using casein …
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Regulation of Myo5p function by phosphorylation
… the actin cytoskeleton. In vitro, p21-activated kinases (PAKs) can phosphorylate a single serine in the myosin-I head domain, referred to as TEDS site, thereby activating the myosin-I ATPase. This work demonstrates that phosphorylation of the Myo5p TEDS site is required for two myosin-I in vivo …
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Protein phosphatases and protein kinases in dictyostelium
… phosphate (pnpp) phosphatases and 2 protein kinases from <i>Dictyostelium</i> are described. .Two of the protein phosphatases are shown to have subunit structures. All of the protein phosphatase activities described were able to dephosphorylate sites on proteins that had previously been …
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Exploiting Chemical Libraries to Identify and Characterize Novel Bioactives with Efficacy Against Pathogenic Candida Species
… program to optimize inhibitors of the fungal casein kinase, Yck2. An existing Yck2 inhibitor, GW, was rationally modified to generate substituted analogues and imidazo[1,2-a]pyridine bio-isosters to improve metabolic stability. I identified four analogues with improved stability that retained …
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Understanding The Repair Mechanisms at Ionizing Radiation-induced Damage in The Human Genome
… was dependent on XRCC1 phosphorylation by casein kinase 2 (CK2) that enhanced the interaction of XRCC1 with the end resection enzymes Mre11 and CtIP. The XRCC1 immunocomplex isolated from U2OS cells had Alt-EJ activity in vitro; this activity was significantly higher in the immunocomplex …
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The Role of Post-Translation Regulation of Twist Expression In The Tumor Progression of Squamous Cell Carcinoma of Head and Neck
… TWIST has a putative phosphorylation site for casein kinase 2 (CK2) suggesting that this kinase could serve as a link between IL-6 stimulation and Twist stability. To test this hypothesis, we used a CK2 inhibitor and shRNA to CK2 and found that these interventions inhibited IL-6 stimulation of …
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Identification of echinus and characterization of its role in Drosophila eye development
… Clathrin, the scaffolding protein RACK1 and the casein kinase I epsilon (Dco). Co-immunoprecipitation additionally identified an interaction between Echinus and Enabled. This work has revealed echinus to be an important regulator of cell sorting and adherens junction formation in the developing …
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