Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Casein Kinase 1"”.
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Novel Prognostic Markers and Therapeutic Targets for Glioblastoma
… in glioblastoma cells we found a list of 20 kinases that can be considered glioblastoma survival kinases. These survival kinases which we term as survival kinase genes, (SKGs) were investigated to find prognostic markers as well as therapeutic targets for glioblastoma. Analyzing these …
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Biochemical and Structural Studies of the Role of FKBP(L)s in the fly and Mammalian Circadian Cycle
… homologues FKBP51, FKBP52 and FKBPL. In vitro kinase assays showed that all three proteins stimulate CK1δ phosphorylation activity towards casein. Among these three proteins, FKBP51 was seen to bind mammalian casein kinase 1 delta (CK1δ) with much stronger affinity than the other FKBPs. From …
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The Role of CK1 in Necroptosis and Confirmation of Amyloid-Like Fibers in Necroptosis Using 2D SDD-AGE
… which contains receptor-interacting protein kinase 1 and 3 (RIPK1, RIPK3) and mixed-lineage kinase domain-like protein (MLKL). Phosphorylation of human RIPK3 at serine 227 (S227) has been shown to be required for downstream MLKL binding and necroptosis progression. Tandem immunoprecipitation …
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TDP-43 and its role in neurodegeneration
… of TDP-43. In addition, Drosophila homologue of Casein Kinase 1- (CK1-), dbt, is a “specific kinase” that phosphorylates “disease-specific site S409/410” and in particular phosphorylation of S409/410 by dbt correlates to severe toxic eye phenotype and partial lethality in ALS mutant Q331K. Our …
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Identification and characterisation of FAM83 proteins as key regulators of CK1 protein kinases in cells: FAM83D recruits CK1α to the mitotic spindle for proper spindle positioning
… FAM83 proteins bind to different isoforms of the casein kinase 1 (CK1) family of Ser/Thr protein kinases and direct them to the distinct cellular sites in which the FAM83 proteins reside. FAM83 members mediate CK1 binding through their conserved DUF1669. In this capacity, FAM83 proteins may act as …
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Investigating FAM83H, a protein mutated in Amelogenesis Imperfecta
… with different isoforms of the protein kinase CK1 (formerly known as Casein Kinase 1) family via the DUF1669 domain. It is believed that FAM83 proteins may act as subcellular anchors and key regulators of CK1 isoforms. CK1 is thought to be a constitutively active serine/threonine protein …
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Understanding Host-Pathogen Interactions of Rift Valley Fever Virus That Contribute to Viral Replication
… of the L protein using similar methods. CK1α, a kinase, and PP1α, a phosphatase, were chosen for further verification due to data demonstrating the L protein is phosphorylated on at least one serine residue, in addition to PP1α already being shown to impact RVFV replication. Inhibition of CK1 and …