Global ETD Search
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Showing 1 to 3 of 3 for “"Cas10-Csm"”.
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Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems
… parasite's DNA and RNA. Type III loci contain Cas10 and Csm2-5, which make up the main Cas10-Csm targeting complex. In addition, loci typically contain an ancillary RNase, csm6 or csx1. Upon target transcription, the Cas10-Csm complex recognises a viral transcript containing a target, which …
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Identification and Characterization of Novel CRISPR-Cas Immune Effectors
… The first is destruction of ssDNA by the Cas10-Csm complex, specifically via the catalytic activity of the HD domain within the Cas10 protein. Second, and exclusive to type III CRISPR, is the synthesis of cyclic oligoadenylate molecules (cOAs) of various sizes from ATP substrates by the …
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Roles of non-Cas nucleases in Type III-A CRISPR-Cas immunity
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01