Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Cartilage tissue engineering"”.
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Chitosan fibrous scaffolds for cartilage tissue engineering
… with glycosaminoglycans make it attractive for cartilage engineering despite its limited cell adhesion properties. Structural and chemical characteristics of chitosan scaffolds may be improved for cartilage engineering application. We planned to evaluate chitosan meshes produced by a novel …
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Novel Biomaterials for Applications in Cartilage Tissue Engineering
… joint condition involving the deterioration of cartilage and subchondral bone, which impacts millions of individuals globally. Its high prevalence is attributed to the ineffective intrinsic healing of cartilage due to its avascular nature. Consequently, the limited healing capacity of cartilage, …
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Optimizing a scaffoldless approach for cartilage tissue engineering
Articular cartilage has a poor intrinsic healing response, so tissue engineering provides a promising approach for cartilage regeneration. The major objective of this proposal was to enhance the self-assembling process, used in articular cartilage tissue engineering, by investigating the effects of …
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Injectable hyaluronic acid scaffolds for cartilage tissue engineering
Every year tens of millions worldwide suffer from cartilage damage, caused by mechanical degradation, trauma or disease. Because of the lack of blood supply and low cell concentration within the tissue, cartilage has very limited regenerative ability. Although current treatments can provide …
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Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering
Articular cartilage provides a bearing surface for transmitting forces across joints. The poor ability of cartilage to self-repair has motivated efforts to engineer replacement tissues, and mesenchymal stem cells (MSCs), which can undergo chondrogenesis, have emerged as a promising cell source. To …
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Decellularized cartilage as a chondroinductive material for cartilage tissue engineering
Cartilage defects, whether caused by osteoarthritis, joint trauma, or other disease, have provoked a wide variety of tissue engineering scaffold strategies in recent years. Traditionally, cartilage tissue engineering scaffolds have utilized synthetic polymer components to form hydrogels or other …
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Deformation and fracture of soft materials for cartilage tissue engineering
Damaged cartilage can cause severe pain and restricted mobility, with few long term treatments available. The developing field of tissue engineering offers an alternative to the currently used full joint replacement. Restoring damaged cartilage through tissue engineering would enable an active …
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Developing osteoarthritis treatments through cartilage tissue engineering and molecular imaging
Tissue engineering can be applied to develop therapeutic techniques for osteoarthritis, a degenerative disease caused by the progressive deterioration of cartilage in joints. An inherent goal in developing cartilage-replacement treatments is ensuring that tissue-engineered constructs possess the …
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Cell-seeded type II collagen scaffolds for articular cartilage tissue engineering
Defects in articular cartilage exhibit little spontaneous healing response, in part due to the limited number of chondrocytes available to infiltrate the defect and the absence of a provisional fibrin scaffold to accommodate cell migration into the lesion. One variable related to tissue engineering …
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Design of an Electrospun Type II Collagen Scaffold for Articular Cartilage Tissue Engineering
Traumatic defects in articular cartilage can lead to joint disease and disability including osteoarthritis. Because cartilage is unable to regenerate when injured, the field of tissue engineering holds promise in restoring functional tissue. In this research, type II collagen was electrospun, …
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Electrospun Scaffolds for Cartilage Tissue Engineering: Methods to Affect Anisotropy, Material and Cellular Infiltration
… producing electrospun scaffolds for use in the tissue engineering of articular cartilage. We developed a novel method of imparting mechanical anisotropy to electrospun scaffolds that allowed the production of a single, cohesive scaffold with varying directions of anisotropy in different layers …
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Gene-supplemented collagen-glycosaminoglycan scaffolds for nonviral gene delivery in articular cartilage tissue engineering
… have been shown to be important for articular cartilage tissue engineering. A major problem in using recombinant proteins in vivo, however, is the inability to maintain therapeutic levels over prolonged times due to degradation or diffusion from the defect site. The goal of this thesis was to …
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Preconditioning Methods in Cartilage Tissue Engineering: Influences of Silk Material Properties and Hypoxia on Chondrogenesis
Cartilage has limited intrinsic healing potential, due to the low cell density and the lack of blood supply. Current treatments for cartilage repair rarely restore full structure and function to the native state. Tissue engineering holds promise to create cartilage grafts capable to withstand the …
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The Influence of Manufacturing Method and Collagen on the Mechanical Performance of Sodium Alginate-Based Scaffolds for Cartilage Tissue Engineering
Cartilage has limited ability to repair itself making it a good candidate for artificial tissue replacements. Hydrogels such as sodium alginate (SA) have been used in bioprinting and tissue engineering for their favourable properties, however, the mechanical performance of engineered tissue …
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Engineering Collagen Nanostructure to Enable Stiff & Tough Cartilage Biomaterials
… the body, and the main structural component of cartilage tissue. As such, collagen has been widely investigated as a biomaterial for tissue engineering. However, the process of extracting collagen and processing it to form functional materials has failed to recapitulate the mechanical and …
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Effects of biochemical and mechanical stimulation of articular chondrocytes in collagen-GAG scaffolds : extracellular matrix biosynthesis and scaffold stiffness
… conditions continues to grow, rehabilitation via tissue engineering is becomingly increasingly attractive as an alternative to traditional surgical interventions. Chapters 2 and 3 of this thesis are specifically concerned with cartilage tissue engineering, while chapter 4 is relevant to bone and …
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Multi-Cellular And Multi-Scale Approaches For Cartilage Repair
… interventions that can fully restore damaged cartilage. While the field of tissue engineering has emerged as a potential solution, there exist numerous shortcomings in existing technologies. This thesis addresses some of these shortcomings by developing multi-cellular and multi-scale …
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Tissue Engineering Cartilage with a Composite Electrospun and Hydrogel Scaffold
… by degeneration and loss of articular cartilage which leads to pain, and loss of joint motility and function. Individuals suffering from severe osteoarthritis are commonly treated with full knee replacements. The procedure does eliminate the problem of degrading cartilage tissue; …
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Synthesis and characterization of matrix metalloproteinase sensitive hydrogels for articular cartilage engineering
… of encapsulated marrow stromal cells for cartilage tissue engineering applications. The scaffold was formed from an unsaturated macromer, oligo(poly(ethylene glycol) fumarate), developed in our laboratory. A matrix metalloproteinase sensitive peptide was used to crosslink the macromer, …
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Method for quantitative analysis of glycosaminoglycans and type II collagen in chondrocyte-seeded articular cartilage scaffolds with varied cross-linking density
Articular cartilage tissue engineering is a useful tool to study and enhance the wound healing processes of articular cartilage in vivo. Current tissue engineering scaffolds for articular cartilage are produced by cross-linking type II collagen with glycosaminoglycans (GAG), creating pores in the …
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