Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Cartilage repair"”.
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A tissue engineering strategy for integrative cartilage repair
Tissue engineering for cartilage repair is a promising approach for improving the healing of articular defects, as biomaterials and growth factors can be supplied directly to a focal lesion. However, integrating neo-tissue with native cartilage to provide mechanical and biological continuity at the …
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Multi-Cellular And Multi-Scale Approaches For Cartilage Repair
… interventions that can fully restore damaged cartilage. While the field of tissue engineering has emerged as a potential solution, there exist numerous shortcomings in existing technologies. This thesis addresses some of these shortcomings by developing multi-cellular and multi-scale …
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Outcome measurement in articular cartilage repair: exploring the patient perspective
… of outcome measurement after articular cartilage repair (ACR) of the knee. The work represents the evolution and development of the author's coherent research programme in this field over a period of 8 years. In 2003 the author conducted a comparative analysis of rehabilitative …
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Optimizing chondrogenic factors and protein delivery methods for cartilage repair
… are common and often result in damage to cartilage, which has a limited ability to repair itself. Tissue engineering is a promising approach for improving cartilage healing in which biomaterials and chemical factors are supplied to direct cells to create a new tissue. The objective of this …
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A MULTISCALE APPROACH TO STEM CELL-BASED CHONDROGENESIS FOR CARTILAGE REPAIR
… engineering is a possible method for long-term repair of cartilage lesions, but current tissue-engineered cartilage constructs have inferior mechanical properties compared to native cartilage. This problem may be due to the lack of an oriented structure in the constructs at the microscale that …
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Controlled growth factor delivery from biodegradable hydrogel scaffolds for articular cartilage repair
… as carriers of growth factors for articular cartilage repair has been investigated. In vitro release studies examined release of transforming growth factor-beta1 (TGF-beta1) directly from OPF hydrogels and also from gelatin microparticles encapsulated within these OPF networks. These studies …
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Optimization and Translation of MSC-Based Hyaluronic Acid Hydrogels for Cartilage Repair
… injury and disease disrupt the ability of cartilage to carry joint stresses and, without an innate regenerative response, often lead to degenerative changes towards the premature development of osteoarthritis. Surgical interventions have yet to restore long-term mechanical function. Towards …
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Proteoglycan-4 in Equine Joint Disease, Exercise, and in vitro Cartilage Repair
… synergistic contributions to tissue health and cartilage boundary lubrication. The biological consequences of joint injury or disease such as osteoarthritis (OA) may include altered concentration, structure, and function of PRG4 and HA, leading to degraded SF quality and function, changes which …
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Bone Marrow-Derived Buffy Coat Can Supplement the Bone Marrow Stimulation Technique for Articular Cartilage Repair
… Bone Marrow Stimulation Technique for Articular Cartilage Repair Bone marrow stimulation (BMS) has been used as a popular operating technique to repair defect of knee articular cartilage. However, the regenerated tissue from BMS is known as a fibrocartilage rather than a hyaline cartilage and …
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Use Of synthetic solid scaffolds to mechanically support a chondrocyte-seeded peptide hydrogel for articular cartilage repair
… (PTOA) is a subtype of OA associated with cartilage defects caused by traumatic joint injury. Because articular cartilage has a limited innate healing response, due to its avascular, aneural, and alymphatic nature, these defects lead to chronic degenerative joint disease if left untreated. …
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Single-dose growth factor treatments to enhance cell recruitment and neotissue integration in an augmented microfracture cartilage repair model
Focal cartilage defects caused by joint injury have a limited capacity to self-repair, and if left untreated, can lead to the early onset of osteoarthritis. The current gold standard of care, microfracture surgery, induces an endogenous repair response, but typically results in poorly integrated …
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A novel osteochondral composite consisting of a self-assembling peptide hydrogel and 3D printed polycaprolactone scaffold : potential for articular cartilage repair
… traumatic injuries are both prominent causes of cartilage defects. Due to its avascular nature, adult human cartilage displays limited capacity for regeneration. Current surgical treatments to induce a spontaneous repair response rely on access to the subchondral bone region. These procedures …
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Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery
The inability of articular cartilage to heal after damage or disease has motivated investigation of novel cartilage tissue engineering technologies. The objective of this thesis was to advance the use of self-assembling peptide hydrogel scaffolds for cartilage repair by encapsulating …
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Photoactivated Fixation of Cartilage Tissue
Cartilage repair and/or replacement is necessary for many orthopaedic conditions including fissures from blunt trauma, autograft or allograft transplantation, and replacement of focal defects with biological or synthetic constructs. In cartilage repair, initial integration between the host tissue …
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The effect of synthetic cannabinoids on wound healing of chondrocytes monolayers and pseudo 3D cartilage tissue. Effect of different concentrations of synthetic cannabinoids WIN55, 212-2, URB602 and HU-308 with and without their antagonists on wound healing of chondrocyte monolayers and pseudo 3D cartilage tissue.
… of cannabinoids and also their potentials for cartilage repair and regeneration. Various wound healing techniques can be used to investigate the mechanisms of chondrocyte repair in monolayers or three dimensional tissue constructs. The effect of different concentrations of the synthetic …
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Chondrogenic capacities of equine synovial progenitor populations
… involves compromised homeostasis of articular cartilage and eventual loss of this tissue in affected joints. Mesenchymal stem cells (MSCs) provide promise for cell-based therapies for articular cartilage repair; however, MSCs from specific tissues exhibit source-based differences in phenotypic …
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A Comparison of the Wear Resistance of Normal, Degenerate, and Repaired Human Articular Cartilage
… is caused by the "wear and tear" of articular cartilage on the surface of bones in synovial joints. It is a chronic problem that is slowed with different types of therapies, including pharmaceutical, nutritional and surgical, but to date the wearing down of the cartilage cannot be stopped or …
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Application of endostatin using nonviral gene delivery toward the regeneration of articular cartilage
Articular cartilage is avascular, and defects have limited capacity for spontaneous healing. Angiogenesis may interfere with maturation of naturally avascular tissues. Our rationale is that the use of endostatin, a potent angiogenesis inhibitor, will facilitate the formation of hyaline cartilage …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
Cartilage has a limited endogenous ability for self-repair and current clinical treatments for damaged or diseased cartilage tissue are insufficient. Additionally, there is a biological and mechanical interplay between cartilage and the underlying subchondral bone, linking the …
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Ultrastructure and nanomechanical properties of aggrecan from native cartilage and engineered tissue
… aggrecan, one of the major components of the cartilage extracellular matrix, are responsible for ~50% of the equilibrium compressive elastic modulus of the tissue. The bottle-brush-shaped aggrecan consists of a core protein to which ~100 sulfated glycosaminoglycan (sGAG) chains are attached. …
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