Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Cartilage regeneration"”.
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Stem cell matrix and cartilage regeneration
Cartilage defects caused by injuries of the knee affect about 900,000 Americans annually, resulting in more than 200,000 surgical procedures. Cartilage repair remains a major challenge due to its limited healing capacity. Current cell-based therapy using autologous chondrocyte implantation has been …
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Application of Scaffold-Free Cartilage to Cartilage Regeneration
"TABLE OF CONTENTS ABSTRACT ------------------------------------------ i TABLE OF CONTENTS ------------------------------ vi LIST OF FIGURES ----------------------------------- vii LIST OF TABLES ------------------------------------ ix I. INTRODUCTION ------------------------------------ 1 II. …
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Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing
… pathway plays a central role in bone and cartilage embryonic development, processes that are recapitulated during regeneration. Imbalance in such well conserved and complex system often contributes to numerous diseases, whereas controlled modulation of the Wnt signaling activity is an …
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Development of bi-layer mineralized bone and cartilage regeneration template
… extensively and proven to be capable of tissue regeneration in vivo for applications including skin regeneration templates, hollow nerve guides and conjunctiva regeneration. While the current CG scaffold has been thoroughly examined both mechanically and clinically, it has yet to prove …
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Development and Characterization of Photocrosslinkable Hyaluronic Acid Hydrogels for Cartilage Regeneration
Damage to cartilage from general wear, disease, or injury can lead to joint pain and tissue degeneration. With its limited ability for self-repair, cartilage has become a target for tissue engineering (TE). As current treatments have yet to provide long-term functional cartilage repair, this …
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Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration
… the potential to permanently restore damaged cartilage in arthritic joints, yet chondrocyte hypertrophy is a major barrier for translational therapy. With chondrogenic differentiation, hBMSCs/SSCs undergo hypertrophy <i>in vitro</i> and mineralisation <i>in vivo</i>, leading to inferior …
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Development of a collagen-glycosaminoglycan analog of extracellular matrix to facilitate articular cartilage regeneration
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1998.
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An electrospinning apparatus for the production of heterogeneous scaffolds and their application in cartilage regeneration
… the development of a scaffold which mimics the cartilage-bone ECM interface. The scaffold is a combination of fibers made from three separate solutions: 1) gelatin-NaCS in dH_2O and ethanol, 2) gelatin-NaCS-HA/[beta]-TCP in dH_2O and ethanol, and 3) PCL-HA/[beta]-TCP in methylene chloride and …
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Hyaline Cartilage versus Fibrocartilage Formation within Mechanically Loaded Cartilage Constructs: In Vitro and In Vivo Studies
Articular cartilage is a type of hyaline cartilage and it is crucial for joint movements, but aging or injury can cause changes that result in pain and disability. Osteoarthritis (OA) is a major joint disease resulting from advanced cartilage degeneration. Current surgical treatments do not allow …
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Effects of Mild Heating on the Osteogenic Differentiation of Human Mesenchymal Stem Cells during Inflammation
… be used as part of a novel therapy for bone and cartilage regeneration. They are a highly regulated, self-renewing population of cells with potent mechanisms to avoid allogeneic rejection, offering significant potential for the generation of tissue that can replace damaged areas in the body with …
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Decellularized cartilage as a chondroinductive material for cartilage tissue engineering
Cartilage defects, whether caused by osteoarthritis, joint trauma, or other disease, have provoked a wide variety of tissue engineering scaffold strategies in recent years. Traditionally, cartilage tissue engineering scaffolds have utilized synthetic polymer components to form hydrogels or other …
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Development of a High-Throughput Human iPSC Chondrogenesis Platform and Applications for Arthritis Disease Modeling
… patient-specific tissue types, such as hyaline cartilage, for applications in regenerative medicine, disease modeling, and drug screening. In many cases, however, these differentiation approaches are poorly controlled and generate heterogeneous cell populations. In this dissertation, we …
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Tissue Engineering the TMJ Condyle using Human Umbilical Cord Mesenchymal Stromal Cells
… approach in which hUCMSCs and mature hyaline cartilage cells, scaffolds, and growth factors were integrated to create TMJ condylar bone and cartilage in vitro to substitute for deteriorated native tissues. hUCMSCs were successfully differentiated along chondrogenic and osteogenic lineages in a …
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Injectable hyaluronic acid scaffolds for cartilage tissue engineering
Every year tens of millions worldwide suffer from cartilage damage, caused by mechanical degradation, trauma or disease. Because of the lack of blood supply and low cell concentration within the tissue, cartilage has very limited regenerative ability. Although current treatments can provide …
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Optimizing a scaffoldless approach for cartilage tissue engineering
Articular cartilage has a poor intrinsic healing response, so tissue engineering provides a promising approach for cartilage regeneration. The major objective of this proposal was to enhance the self-assembling process, used in articular cartilage tissue engineering, by investigating the effects of …
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In vitro and in vivo growth factor delivery to chondrocytes and bone-marrow-derived stromal cells in cartilage and in self-assembling peptide scaffolds
The inability of articular cartilage to repair itself after acute injury has been implicated in the development of osteoarthritis. The objective of this work was to develop methods for delivering growth factors to cartilage and to test the ability of a self-assembling peptide scaffold, (KLDL)3, …
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A pulsatile bioreactor system for durability testing and compliance estimation of vascular grafts
… clinical solutions in the areas of skin and cartilage regeneration and is advancing in several research fields, such as vascular graft replacements. In order for TE constructs to be cultivated and conditioned under a controlled environment, bioreactors systems are used, that can maintain …
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Enhancing Chondrocyte Biosynthetic Activities: Harnessing the Power of Loading-Induced Evolved Temperature
Chondrocytes within articular cartilage possess the capacity to perceive and react to signals generated by the typical load-bearing actions of daily life, such as walking or running. Articular cartilage is predominantly oriented toward compression-based functionality, and thus the application of …
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3D Bioprinting Meniscus for Future Tissue Replacement in Osteoarthritis Affected Knee Joints
Progressive cartilage defects in human knee joints are a worldwide health issue that exposes a great burden on society as well as on single individuals. Sudden traumas to the knees can induce tears in the structures of the joints such as the articular cartilage and the meniscus. Lesions in the …
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Novel Biomaterials for Applications in Cartilage Tissue Engineering
… joint condition involving the deterioration of cartilage and subchondral bone, which impacts millions of individuals globally. Its high prevalence is attributed to the ineffective intrinsic healing of cartilage due to its avascular nature. Consequently, the limited healing capacity of cartilage, …
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