Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Cartilage degeneration"”.
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Physical diagnostics of cartilage degeneration
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, February 1999.
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Design of an in-vivo probe to detect cartilage degeneration
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1998.
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The Mechanism of Action of Hyaluronan Therapy as a Treatment for Osteoarthritis and the Assessment of Osteoarthritic Articular Cartilage Using Ultrasound
… hyaluronan (HA) therapy interacts with articular cartilage at the molecular and tissue level, and (2) whether quantitative ultrasound imaging can detect early degenerative changes in articular cartilage before irreversible osteoarthritic damage develops. By combining molecular characterisation, ex …
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A Biphasic Multiscale Investigation of the Biomechanical Microenvironment of Articular Cartilage
… a debilitating joint disease that involves the degeneration of articular cartilage. Although much research has been conducted at the macroscale level, the microscale level is poorly understood. This thesis investigated the micromechanical environment of cartilage cells that is thought to …
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The Role of Piezo1 in Mediating Chondrocyte Cell Signaling and Senescence
… cause of disability, is driven by articular cartilage degeneration and inflammation. Mechanosensitive ion channels PIEZO1 and PIEZO2 have been implicated in OA progression via calcium signaling in chondrocytes. This study investigates the role of conditional Piezo channel knockout (cKO) in …
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
… (PTOA) refers to the progressive degradation of cartilage often triggered by a traumatic joint injury, such as a tear of the meniscus or anterior cruciate ligament (ACL). Such impact injuries lead to elevated levels of inflammatory cytokines in the synovial fluid of the joint, including IL-1, …
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Elbow Joint Contact Mechanics: Multibody and Finite Element Methods
Only a few millimeter thick articular cartilage is a very specialized connective tissue which withstands high compressive and shear forces while protecting the bone from excessive loading, and provides a smooth articulation for the joint. Better understanding of elbow cartilage contact mechanics …
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Biomechanical And Biological Evaluation Of A Model Of Post-Traumatic Osteoarthritis Following Noninvasive, Traumatic Rupture Of The Anterior Cruciate Ligament
… degenerative joint changes, and articular cartilage degeneration was most profound in the medial compartment of the femur. The two models yield in a differential bony remodeling response, and surgical ACL transection causes more drastic degenerative changes of articular cartilage. …
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The Effects of Non-Surgical Interventions on Osteoarthritis-Like Changes in the Mouse Knee
… HA injections to prevent knee joint degeneration, and secondly to examine the capacity of moderate exercise to prevent onset and progression of joint degeneration. Intra-articular injections of TGF--β1 into murine knees produce synovial hyperplasia, osteophyte formation, and fibrotic …
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Total Knee Arthroplasty Wear Is Caused by Malrotation and Excessive Laxity
… components and surgical processes to treat cartilage degeneration and alleviate pain in arthritic knees. However, this technique is limited by component design and surgical precision. Due to these limitations, knee arthroplasty components will eventually wear out, causing rejection and …
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Statistical Modeling to Investigate Anatomy and Function of the Knee
… anatomy and may include patellar maltracking, cartilage degeneration (e.g. osteoarthritis), or acute injuries such as meniscal or ligamentous tears. Population variability makes broadly applicable conclusions about etiology of these conditions from small-scale investigations challenging. The …
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Quantitative Magnetic Resonance Imaging of Knee Articular Cartilage and Effusion-Synovitis: The Structural Response to Changes in Joint Loading
… OA studies. Specifically, changes in articular cartilage composition and/or effusion-synovitis were examined in people with or at risk for knee OA and healthy controls, and after altering joint loads. Chapter 2 is a systematic review that studied articular cartilage composition using MRI T2 and …
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Impact loading and functional tissue engineering of articular cartilage
… for alleviating the problem of articular cartilage degeneration: mitigating degradative changes that follow mechanically induced injuries and growing functional neo-cartilage for diseased tissue replacement. Experiments demonstrate that cartilage subjected to a single, non-surface …
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The Roles of the Normal Mechanical Properties of Articular Cartilage in the Contact Mechanics of the Human Knee Joint: a Finite Element Approach
… to the study of the mechanical behaviour of cartilage, few of them considered fluid pressure in an anatomically accurate knee joint model. Including the fluid phase as a cartilage constituent, this thesis investigated the mechanics of human knee joint. The main hypothesis of this thesis was …
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In vivo Mechanical Metrics for the Quantitative Assessment of Cartilage Health
… 27 million Americans. OA is characterized by the degeneration of cartilage tissue, and presents clinically with joint pain, stiffness, and limited range of motion. As such, it is a leading cause of disability in the United States. Current treatment options for OA focus on relieving pain (either …
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Charge-based transport and drug delivery into cartilage for localized treatment of degenerative joint diseases
… of pro-inflammatory cytokines that can initiate cartilage degeneration leading to osteoarthritis (OA). Articular cartilage is a highly negatively charged, avascular tissue, which relies on synovial fluid convection and electro-diffusion to transport proteins and therapeutics to tissue …
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Finite Element Modeling and Validation of the Patellofemoral Joint
… U-shaped intercondylar groove, and the articular cartilage that covers both the distal femur and posterior patella. Articular cartilage has several functions to enhance functionality in this joint (e.g., reduce friction, shock absorption, load distribution). Patellofemoral disorders are a leading …
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Design of Biomaterials toward Endogenous Skeletal Tissue Repair
… fracture healing as well as irreversible cartilage degeneration following joint injury. To improve the repair outcome, recent advancements have been made in regenerative medicine involving administration of tissue-specific growth factors and transplantation of stem cells. While they have …
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Biotribology: Studies of the Effects of Biochemical Environments on the Wear and Damage of Articular Cartilage
… partially characterized by the loss of articular cartilage from the contacting surface of the articulating bones in synovial joints. Although it has been studied extensively, the exact pathways and pathogenesis of OA have yet to be determined. Several factors have been cited as possible …
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