Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Cartilage Oligomeric Matrix Protein"”.
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Cartilage oligomeric matrix protein in der Pathogenese der Arthrosis deformans
… Mitglied der Thrombospondin-Gen-Familie, ist das Cartilage oligomeric matrix protein (COMP) hauptsächlich in der extrazellulären Matrix zu finden. Eine häufige Bindung an Knorpel konnte bereits nachgewiesen werten. Weiter ist COMP in Synovialflüssigkeiten und dem Bandhalteapparat nachweisbar. Es …
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In Vitro Equine Flexor Tendonitis: New Model Development and Therapeutic Investigation
… by real time PCR to assess gene expression for matrix metalloproteinases (MMP)-1, MMP-3, and MMP-13, collagen types I and III, and the non-collagenous proteins cartilage oligomeric matrix protein (COMP) and decorin. Data will be analyzed by analysis of variance and post-hoc comparisons. …
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Adipose-Derived Adult Stem Cells as Trophic Mediators of Tendon Regeneration
… stem cells and increasing extracellular matrix production by tendon fibroblasts (TFBL). The purpose of this study was to evaluate the ability of adipose-derived cells (ADC) culture expanded from the SVF to act as trophic mediators in vitro. We hypothesized that ADCs would produce growth …
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Porcine urinary bladder matrix in an in vitro equine model of tenogenesis
Extracellular matrix (ECM) is responsible for tendon strength and elasticity. Healed tendon ECM lacks structural integrity, leading to reinjury. Porcine urinary bladder matrix (UBM) provides a scaffold and source of bioactive proteins to improve tissue healing, but has received limited attention …
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In vitro comparison of equine tendon- and bone marrow-derived cells expanded with FGF-2 prior to culturing with tendon matrix and IGF-I
… to culture with autogenous acellular tendon matrix and insulin-like growth factor-I (IGF-I). Progenitor cells were isolated from six young adult horses, expanded in monolayers with FGF-2, and cultured with autogenous acellular pulverized tendon and IGF-I for seven days. Initial cell isolation …
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Biomarkers of Physiological Damage and their Potential for Work-Related Musculoskeletal Disorder Risk Assessment
… Existing work has identified biomarkers of cartilage and muscle damage, and demonstrated responsiveness to various forms of physical activity and biomechanical loading. Here, three studies were complete to further assess the occupational relevance/utility of three selected biomarkers: …
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A Randomized Controlled Trial Comparing Equine-Assisted Therapy and Exercise Education for Adults and Older Adults with Arthritis
… and enjoyment of nature. Biomarkers measured cartilage and muscle status. Results supported the feasibility and acceptability of the research design, protocol, and methods. Findings indicated significant improvements in back, hip, and shoulder pain, and back and hip range of motion. Quality of …
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Complement in Disease - Extracellular Proteins as Complement Regulators
… joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. The aim of this thesis is to find new interactions between cartilage components and …
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Covalent Modification that Enhances Protein Properties and Functions and Folds Random Coil into Alpha-Helix
… science of aggregation and surface adsorption of proteins is critical for developing protein-based drugs, understanding aggregation-induced diseases and for preventing biofouling that impacts a wide range of industries. In spite of the advances in sensitive and high-throughput analytical methods, …
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Systemic sclerosis. Novel molecular and epidemiological features of disease.
… but similar to reports from southern Europe. Cartilage oligomeric matrix protein (COMP) is a promising biomarker of skin fibrosis in SSc. We have investigated the potential for S-COMP to serve as a biomarker for SSc associated lung fibrosis and as a predictor of SSc survival. S-COMP showed …
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Treatment of arthritis with tumour necrosis factor antagonists. Clinical, immunological and biochemical aspects
… clinical practice, (ii) whether serum levels of cartilage oligomeric matrix protein (COMP) change during treatment with TNF antagonists in a way that corroborates a tissue protective effects of these agents in rheumatoid arthritis (RA), (iii) how different anti-rheumatic treatments modulate the …
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In vitro characterization and in vivo assessment of equine tendon-derived progenitor cells
… insulin-like growth factor supplementation. Matrix production and matrix gene expression were analyzed at the end of in vitro culture. During monolayer expansion, at each passage, the yield of TDPCs was 3-fold higher than the matched BM-MSCs. The viability of TDPCs on acellular tendon …
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
… (PTOA) refers to the progressive degradation of cartilage often triggered by a traumatic joint injury, such as a tear of the meniscus or anterior cruciate ligament (ACL). Such impact injuries lead to elevated levels of inflammatory cytokines in the synovial fluid of the joint, including IL-1, …
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Molecular and functional analyses of human synovial B-lymphocytes in rheumatoid arthritis
… was analyzed for its specific recognition of cartilage antigens. A heptameric peptide of cartilage oligomeric protein (COMP) could be defined as the target structure. The IgVH-gene (IgHV4-59*01) of the IgG2l hybridoma has somatically mutated genes with high R/S values in the CDR regions (9:2). …
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Comparison of bone marrow mesenchymal stem cells and tendon progenitor cells cultured on collagen surfaces
… of the newly synthesized extracellular matrix, or administering progenitor cells to enhance repair. Significant research effort has been directed at the use of adult mesenchymal stem cells as a source of progenitor cells for equine tendon repair and recent clinical applications have …