Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 526 for “"Cartilage"”.
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Application of Scaffold-Free Cartilage to Cartilage Regeneration
"TABLE OF CONTENTS ABSTRACT ------------------------------------------ i TABLE OF CONTENTS ------------------------------ vi LIST OF FIGURES ----------------------------------- vii LIST OF TABLES ------------------------------------ ix I. INTRODUCTION ------------------------------------ 1 II. …
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Decellularized cartilage as a chondroinductive material for cartilage tissue engineering
Cartilage defects, whether caused by osteoarthritis, joint trauma, or other disease, have provoked a wide variety of tissue engineering scaffold strategies in recent years. Traditionally, cartilage tissue engineering scaffolds have utilized synthetic polymer components to form hydrogels or other …
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Photoactivated Fixation of Cartilage Tissue
Cartilage repair and/or replacement is necessary for many orthopaedic conditions including fissures from blunt trauma, autograft or allograft transplantation, and replacement of focal defects with biological or synthetic constructs. In cartilage repair, initial integration between the host tissue …
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Mechanical loading and cartilage physiology
… mechanical impact is known to be essential for cartilage maintenance, it has been noted that altered joint loading and increased force may lead to cartilage degradation and increase the risk for the development of osteoarthritis (OA). This study investigated the cellular responses of …
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Decellularized Cartilage for Airway Repair
… to enlarge the airway by implanting autologous cartilage from a rib graft. However, young children often lack sufficiently sized costal cartilage for this procedure, resulting in increased donor site morbidity and operative time, as well as an elevated risk for airway restenosis, necessitating …
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Diffusional Properties of Articular Cartilage
Articular cartilage is the connective tissue that lines joints and provides a smooth surface for articulation and shock absorption. Osteoarthritis, the progressive degeneration of cartilage, is a painful, debilitating, and widespread disease, affecting 70% of people over 65. Because cartilage is …
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Physical diagnostics of cartilage degeneration
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, February 1999.
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Nidogen-1 and Nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilage
Einleitung: Ziel dieser Arbeit war die Untersuchung des Vorkommens und der Funktionen von Nidogen-1 und Nidogen-2 in gesundem humanem Knorpel und in den späten Stadien der Osteoarthritis. Methoden: Die Lokalisierung und Quantifizierung beider Nidogene im Knorpel, sowohl auf Protein als auch auf …
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Subject-Specific Finite Element Predictions of Knee Cartilage Pressure and Investigation of Cartilage Material Models
… and joint contact area and pressure. Abnormal cartilage contact pressure is considered a risk factor for incidence and progression of OA. For this study, three subject-specific tibiofemoral knee FE models containing accurate geometry were developed from magnetic resonance images (MRIs). Linear …
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Regulation of cartilage metabolism by dynamic tissue shear strain and the mechanical characterization of cartilage
I investigated the physical regulation of cartilage metabolism induced by dynamic tissue shear strain, and also the mechanical behavior under shear strain, especially focused on shear modulus, under different shear strain, frequency, compressive offset, and physiochemical environment. For this …
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Hyaline Cartilage versus Fibrocartilage Formation within Mechanically Loaded Cartilage Constructs: In Vitro and In Vivo Studies
Articular cartilage is a type of hyaline cartilage and it is crucial for joint movements, but aging or injury can cause changes that result in pain and disability. Osteoarthritis (OA) is a major joint disease resulting from advanced cartilage degeneration. Current surgical treatments do not allow …
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A Method to Improve Cartilage Integration
One major barrier that prevents cartilage integration following mosaic arthroplasty is the presence of a zone of chondrocyte death (ZCD) that is generated upon osteochondral graft harvest, which can extend up to 400 μm into the cartilaginous portion of the graft. In order for cartilage integration …
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Stem cell matrix and cartilage regeneration
Cartilage defects caused by injuries of the knee affect about 900,000 Americans annually, resulting in more than 200,000 surgical procedures. Cartilage repair remains a major challenge due to its limited healing capacity. Current cell-based therapy using autologous chondrocyte implantation has been …
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Towards understanding multiscale articular cartilage mechanics
… chondrocytes, the sole cell type in articular cartilage, is of high importance to developing and maintaining a healthy tissue state. Mechanical cues play a major role in the regulation of many cellular functions. The dominant mechanics experienced by chondrocytes are translated from physics …
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Inhibition of metalloproteinases in articular cartilage
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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Nanomechanics of cartilage extracellular matrix macromolecules
… nanomechanical properties between opposing cartilage aggrecan macromolecules were probed. In addition, nanoscale dynamic oscillatory mechanical properties of cartilage and its type II collagen network was measured. Aggrecan shear nanomechanics was assessed via microcontact printing and …
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Electrokinetic evaluation of human articular cartilage
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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Cartilage mechanobiology and transcriptional effects of combined mechanical compression and IGF-1 stimulation on bovine cartilage explants
… to combined IGF-1 and static compression in cartilage explants. Discussion: Clustering analysis revealed five distinct groups. TIMP-3 and ADAMTS-5, MMP-l and IGF-2, and IGF-1 and Collagen II, were all robustly co-expressed under all conditions tested. In comparing gene expression levels to …
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SPECTROSCOPIC ASSESSMENT OF TISSUE ENGINEERED CARTILAGE: A PATHWAY FOR BENCH TO BEDSIDE EVALUATION OF CARTILAGE DEVELOPMENT AND REPAIR
Cartilage tissue engineering is a promising approach for the repair of chondral defects. Engineering of cartilage combines a three-dimensional scaffold with chondrogenic cells and appropriate external stimuli, and ideally results in constructs with properties that resemble, as closely as possible, …
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