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Showing 1 to 13 of 13 for “"Carnosine"”.
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Carnosine metabolism and function in the thoroughbred horse
… impairment of the contractile process. Carnosine (ß-alanyl-L-histidine, pK<sup>a</sup> 6.83) occurs at high concentration in equine muscle where it functions as an effective H<sup>+</sup> ion buffer at physiological pH. <br></br><br></br> High-performance liquid chromatography analytical …
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Absorption of carnosine and methionylglycine by sheep ruminal and omasal epithelia
Carnosine and methionylglycine (using ³⁵S-methionylglycine as a representative marker) absorption and transfer across ruminal and omasal epithelia collected from four (carnosine) and seven (methionylglycine) sheep were studied using parabiotic chambers that were repeatedly sampled over a 240-min …
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The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells
The previous studies demonstrated that carnosine (β-alanyl- L -histidine) inhibits the growth of tumor cells in vitro and in vivo. Considering carnosine for the treatment of glioblastoma, we investigated which proton-coupled oligopeptide transporters (POTs) are present in glioblastoma cells and how …
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Carnosine’s inhibitory effect on glioblastoma cell growth is independent of its cleavage
… one of several imidazole-containing dipeptides, carnosine is found primarily in the skeletal muscle, the brain, the olfactory bulb and the kidneys of mammals, fishes and birds. The enzyme Carnosine Synthase 1 regulates its synthesis and the two enzymes responsible for the dipeptide’s cleavage …
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The Effectiveness of Prophylactic Eye Drops on the Reversal of UV-Light Induced Cataracts
… medication, used by veterinarians, containing carnosine as its active ingredient. Topical application of carnosine is reported to be an effective treatment for the prevention and removal of pre-existing cataracts. For this experiment, Sprague- Dawley rats were anesthetized and exposed to …
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Effects of carnosine in experimental models of neuroinflammation: focus on human microglia [Effetti della carnosina in modelli sperimentali di neuroinfiammazione: focus sulla microglia umana]
La microglia, le cellule immunitarie del cervello, sono essenziali per lo sviluppo del cervello, la plasticità sinaptica e la neurogenesi, essendo responsabili del mantenimento dell'equilibrio eliminando proteine mal ripiegate e cellule morte. La perdita dello stato omeostatico della microglia è …
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Antioxidant Nanoparticles as Delivery Systems
… like alpha-tocopherol, vitamin C, and carnosine, are responsible to protect biological systems against free radicals attack. The conjugation of vitamin C-vitamin E (EC) and alpha-tocopherol-carnosine (VECAR) were performed to obtain antioxidant surfactants which were used for polymeric …
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The Longitudinal Effects of Beta-Alanine on Punch Power, Punch Frequency, and Fatigue in Female Amateur Fighters
… BA is a precursor to the cytoplasmic dipeptide carnosine (beta-alanylhistidine). Carnosine is found in high concentrations in human skeletal muscle where it plays a key role in intracellular pH buffering. Research indicates BA supplementation increased punch power, punch frequency, and lactate …
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Design, synthesis, and exploration of a chimeric antioxidant and new crosslinkers for molecular imprinting
… A chimeric antioxidant composed of vitamin E and carnosine (VECAR) was designed and synthesized to improve drug delivery. VECAR was fabricated based on the lipophilicity and hydrophilicity of its individual components and is expected to have increased permeability in hydrophilic media while …
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Iridium Complexes for Intracellular Transfer Hydrogenation and Their Potential Biological Applications
… with conventional aldehyde scavengers such as carnosine or phloretin. The Ir complexes could also increase the viability of zebrafish in acrolein contaminated water by up to 40%. Our work could lead to the creation of new therapeutic methods in treating diseases associated with cytotoxic …
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Demonstration of peptide and free amino acid absorption by sheep forestomach epithelium using parabiotic chambers and identification of H⁺/peptide and free amino acid transport proteins in sheep omasal epithelium and b<sup>o,+</sup> amino acid transport proteins in pig jejunal epithelium by expression of mRNA in Xenopus laevis oocytes
… (Kt = .40 mM), and was inhibited by 5 mM carnosine, Met-Gly, glycylleucine, but not by glycine. The RNA-induced Gly-Sar absorption was completely inhibited when oocytes were co-injected with RNA and DNA oligomers that were complementary to the cloned rabbit H⁺/peptide cotransporter. When …
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Peptides as amino acid sources for the synthesis of secreted proteins by mammary tissue explants and cultured mammary epithelial cells
… higher concentration of glycylsarcosine or carnosine. Incorporation of ³H-leucine promoted by lysyl peptides ranged from 91 to 117% of the incorporation promoted by free lysine. MAC-T cells were also able to utilize methionine from all di- and tri-peptides studied. The ability of the …
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Il TGF-β1 come nuovo target farmacologico nella depressione e nella malattia di Alzheimer
Diversi legami neurobiologici e clinici esistono tra la depressione e la malattia di Alzheimer (AD), tra cui la neuroinfiammazione, lo stress ossidativo e una compromissione della neurotrofina TGF-β1 esercita un ruolo chiave soprattutto nella fisiopatologia dei deficit cognitivi associati a queste …