Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Cargo trafficking"”.
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Optogenetic regulation of protein activity in live cell
… Finally, I review the molecular machinery of cargo trafficking with emphasis on new optogenetic and optochemical experimental strategies that enable direct modulation of cargo trafficking in live cells.
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A functional analysis of Rab11a and Rab11b in endosomal recycling
… including cell division, cell migration and cargo trafficking. Rab11a and Rab11b share over 89% sequence similarity, while Rab25 is approximately 60% similar to Rab11a and Rab11b. Both Rab11a and Rab11b are ubiquitously expressed proteins while the expression of Rab25 is restricted to the …
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Molecular mechanisms of TOM1-mediated protein trafficking in health and disease
… highlight the importance of elucidating protein trafficking pathways and mechanisms in immune responses to help identify new targets for drug therapies and immunomodulating treatments. The first mechanism explored is brought about by the invasion of host cells by Shigella flexneri. S. flexneri …
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Genetic analysis of dynein function in the nervous system and in mitosis
… orchestrates retrograde transport of diverse cargoes in interphase cells and plays multiple roles in mitosis. The importance of this motor is underlined by the fact that mutations in Dynein heavy chain, the motor-containing subunit of dynein, cause neurological disorders in humans. How dynein …
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Binding properties of adaptor proteins Tollip and Tom1
… like Tollip and Tom1, facilitate cellular cargo sorting through their ubiquitin-binding domains. Tollip and Tom1 bind to each other through their TBD and GAT domains, respectively, whereas Tollip interacts with phosphatidylinositol-3-phosphate (PtdIns(3)P)-containing endosomal membranes. …
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Deciphering The Role of Huntingtin In Endosomal Functions
… of the Ras superfamily of small GTPases, govern cargo trafficking through endosomal pathways. Upon endocytosis into early endosomes regulated by Rab5, the endocytosed cargo can either be recycled back to the plasma membrane (via Rab4/Rab11) or degraded through the endosomal-lysosomal pathway (via …
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Phosphatidylinositol 3-phosphate binding properties and autoinhibition mechanism of Phafin2
… acts as a PtdIns(3)P effector for endosomal cargo trafficking, macropinocytosis, apoptosis, and autophagy. The PtdIns(3)P binding activity is critical to the localization of Phafin2 on a specific membrane and, subsequently, helps the recruitment of other binding partners to the same membrane …
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Molecular mechanisms of axonal transport impairment in C9orf72-associated neurodegenerative disease
… nerves of live adult Drosophila impedes axonal cargo trafficking. Accumulations of arginine-rich DPRs on the microtubule tracks lead to increased motor pausing and detachment in vitro. Arrest of transport is more frequently observed in patient-derived neurons and control neurons exposed to …
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Scanning Probe Microscopy Study of Molecular Nanostructures on 2D Materials
… relies on complex forming between Tom1 and the cargo sorting protein, Toll interacting protein (Tollip). The induced conformational change in Tollip triggers its dissociation from the lipid membrane and commitment to cargo trafficking. This collaborative study aims at characterizing the dynamic …
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Characterising the factors involved in ER-to-Golgi anterograde trafficking
… they fuse with the Golgi membrane and release cargo into the Golgi apparatus for further processing. Vesicle recognition at the Golgi apparatus occurs in two steps: long-range recognition via tethering and short-range fusion. The focus of my PhD revolved around the organisation of ER-to-Golgi …