Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Cardiovascular disorders"”.
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The role of heparan sulfate proteoglycans and heparanase in the control of vascular remodeling
… pathophysiological mechanism underlying clinical cardiovascular disorders such as hypertension, atherosclerosis and restenosis. We examined heparan sulfate proteoglycan homeostasis as a mechanism of regulation of arterial vascular remodeling in response to altered mechanical environments such as …
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Cholesterol Binding Activity of ApoAI Mimetic Peptide L4F
According to the current WHO statistic, cardiovascular diseases are the leading cause of deaths all over the world. Over 1.7 million people have died due to cardiovascular disorders like myocardial infarction, coronary artery diseases and stroke. A common condition underlying almost all of these …
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Development of a wearable blood pressure monitor using adaptive calibration of peripheral pulse transit time measurements
… of hypertension, heart failure, and other cardiovascular disorders. Today's familiar blood pressure cuffs are used to diagnose and manage the hypertensive disorders which afflict 65 million Americans. But these existing devices only permit single 'snap-shot' measurements, while true …
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Small Therapeutic Peptides: In vitro pharmacokinetics of alpha-carboxyl terminus 11 peptide in rat plasma
Cardiovascular diseases affect one third of the U.S. population and are the number one cause of death globally. Acute myocardial infarction is one of the most catastrophic cardiovascular diseases that permanently alters patient's lives. Small molecule drugs, surgery, medical devices and lifestyle …
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Die Charakterisierung der differentiellen Genexpression invasiver und nicht-invasiver humaner glatter Gefäßmuskelzellen
… plays a decisive role in the pathogenesis of cardiovascular disorders, like arteriosclerosis and coronary heart disease as well as in restenosis after percutaneous transluminal angioplasty and stent implantation.The objective of this dissertation was to identify genes which are responsible for …
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Acetylation regulates Thioredoxin Reductase activity and oligomerization
… of many diseases ranging from cancer to cardiovascular disorders. Thioredoxin reductase (TrxR) is the key enzyme in the Trx system and contains the 21st genetically encoded amino acid, selenocysteine (Sec). There were multiple experimentally identified TrxR acetylation sites with an …
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Centrinių ir periferinių arterijų struktūrinių ir funkcinių pakitimų ypatumai sergant metaboliniu sindromu /
Cardiovascular diseases (CVD) are the main cause of death all over the Europe and were the most prevalent disease in Lithuania in 2010. Based on some of the data, MS risk factors have different influence on changes of artery structure and function. MS and its components can influence differently …
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PLANT BIOACTIVE COMPOUNDS FOR SUSTAINABLE NUTRITION AND PREVENTION OF METABOLIC DISEASES
… diseases, including diabetes, obesity, and cardiovascular disorders, represent a significant global health challenge. Their prevalence continues to rise, necessitating innovative approaches to prevention and treatment. This work focus on bioactive compounds derived from legumes and …
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Studying the Effect of TBX4 Loss-of-Function on Postnatal Lung Development and How it Predisposes to Pulmonary Hypertension
… describes a heterogeneous group of pulmonary and cardiovascular disorders and is estimated to affect 1% of the global population. The World Symposium on Pulmonary Hypertension divides patients into a five-tier classification system based on etiology and clinical findings with the aim of improving …
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Cardiovascular risk profile of adults with psychotic disorders in Eldoret, Kenya
Introduction: Cardiovascular disorders contribute significantly to mortality and morbidity amongst patient's psychotic disorders such as schizophrenia and bipolar mood disorders. In addition to conventional risk factors for cardiovascular disorders (smoking, alcohol use, inadequate physical …
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MAP kinase phosphatase-2 in vascular smooth cell muscle function
The progression of major cardiovascular disorders are a consequence of a pathophysiological modification within the blood vessel; a process often driven by vascular smooth muscle cell hyperproliferation. A major mechanism by which smooth muscle cell proliferation occurs involves ligand-induced …
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Lipids and fatty acid composition of early and term healthy placenta with a specific focus on foetal growth development
… offspring at high risk for the development of cardiovascular disorders later in life.
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Development of the Clinical Application of miRNA with Proregenerative Effect on the Heart
Rationale: Cardiovascular disorders are the first cause of mortality and morbidity worldwide. This is due, at least in part, to the poor regenerative capacity of the heart and the lack of drugs able to foster cardiac regeneration. Our recent work has identified a few human microRNAs (miRNAs), in …
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Flavonoids and Related Compounds as Nucleoside Transporter Inhibitors
… of cancer and viral diseases, but also in cardiovascular disorders and parasitic infections. <br /><br />Due to the absence of crystal structures and limited information regarding the active sites of nucleoside transporters, the designing of novel inhibitors is confined to ligand-based …
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Effects of Modest Weight Gain on Blood Pressure and Sympathetic Neural Activity in Nonobese Humans
… to the development of hypertension and other cardiovascular disorders. Maintenance of higher levels of CRF during periods of weight gain may reduce cardiovascular disease risk by mitigating the increases in blood pressure. Collectively, these findings may have important implications for …
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Self-Powered Wearable Sweat Monitoring using 2D WS2 Textile Integrated Triboelectric Nanogenerators for Future Personalized Healthcare
… burden of chronic diseases such as diabetes, cardiovascular disorders, and neurological conditions highlight the urgent need for continuous, non-invasive health monitoring solutions. Sweat-based sensing has emerged as a promising alternative to traditional diagnostic approaches, offering a …
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NOVEL MONO-, BI- AND TRI-SPECIFIC IMMUNOMODULATORY ANTIBODIES FOR CANCER THERAPY AND TOOLS FOR OTHER THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
… approach has been used also for facing cardiovascular disorders.
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AI-DRIVEN ATRIAL ARRHYTHMIA DETECTION: DEVELOPMENT, CROSS-COMPARISON AND UNCERTAINTY QUANTIFICATION OF ALGORITHMS FOR CLINICAL CONTINUOUS ECGS
… atrial fibrillation (AF), are prevalent cardiovascular disorders characterized by irregular heart rhythms originating from the atria, and affecting approximately 2-3% of the global population. These conditions are associated with increased risks of stroke, heart failure, and other severe …
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Physical activity level and cardiovascular risk factors: case study of high school teachers within Makhado Municipality
Risk factors for cardiovascular diseases are particular habits, behaviours, circumstances that increase a person's risk for developing CVD. The study aimed to determine physical activity level and cardiovascular risk factors among high school teachers within Makhado Municipality. A Predictive …