Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Cardiovascular biology"”.
-
A Microfluidic Approach For Investigating Thrombosis And Hemostasis: From Disease Models To Drug Testing
In vitro studies of cardiovascular biology have often relied on static assays using plasma or isolated blood cells in the past. Microfluidic technologies offer a unique opportunity to study the mechanisms of hemostasis and thrombosis under physiologically relevant conditions. This thesis describes …
-
Distinguishing the Role of the c-myb Proto-Oncogene in Mouse Models of Cardiovascular Disease
… in our understanding of disease processes, cardiovascular diseases remain the top cause of mortality and morbidity in society today. Investigating the molecular and cellular mechanisms involved in the pathogenesis of these diseases to discover new therapeutic targets is of utmost importance. …
-
Investigating iPSC-Derived Macrophage Stimulation with Oxidised Low-Density Lipoprotein as an Effective In Vitro Model of Foam Cells in Atherosclerosis
… expanding our current knowledge of foam cell biology, much remains to be explored. Foam cells can be generated in vitro by lipid loading with modified lipoproteins or cholesterol, however, with a growing appreciation for the complexity of foam cells in vivo there remains uncertainty in which …
-
Genetically-programmed suicide of adrenergic cells in the mouse leads to severe left ventricular dysfunction, impaired weight gain, and symptoms of neurological dysfunction
… and (ii) Pnmt cells are required for normal cardiovascular and neurological function. To genetically ablate adrenergic cells, we mated Pnmt-Cre mice, in which Cre-recombinase is under the transcriptional regulation of the Pnmt promoter, and a Cre -activated diphtheria toxin A (DTA) mouse …