Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 206 for “"Cardiomyopathy"”.
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MOLECULAR DISSECTION OF CARDIOMYOPATHY
Hypertrophic (HCM) and dilated cardiomyopathy (DCM) are inherited cardiac conditions with marked genetic heterogeneity. The genetic aetiology of HCM and DCM in Singapore and European was broadly similar but Singapore Chinese HCM patients frequently have fewer clinically actionable disease variants, …
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Global mortality attributable to alcoholic cardiomyopathy
… between chronic heavy alcohol consumption and cardiomyopathy has long been recognized, with the Tenth Revision of the International Classification of Diseases (ICD-10) listing alcoholic cardiomyopathy (ACM) as a fully alcohol-attributable diagnosis. For a few, predominately high-income …
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The molecular genetics of familial cardiomyopathy
… studied three South African families with severe cardiomyopathy. Clinical diagnosis and recruitment of cardiomyopathy patients into the study was done at Groote Schuur Hospital, Cape Town by a panel of experts. Next generation sequencing data was analysed and filtered through various stringent …
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The impact of erythropoietin on uraemic cardiomyopathy
… the effect of EPO administration on uraemic cardiomyopathy.Uraemia was induced surgically in male Sprague-Dawley rats via a subtotal nephrectomy and animals retained for 3, 6, 9 or 12 weeks post-surgery. EPO was administered subcutaneously twice a week for 2 weeks prior to sacrifice at a dose …
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Natural history and pathogenesis of Takotsubo cardiomyopathy
Introduction: Takotsubo cardiomyopathy (TTC) is a transient left ventricular (LV) systolic dysfunction of uncertain pathogenesis, which occurs predominantly in ageing women. Although there is considerable uncertainty about the pathogenesis of TTC, pronounced catecholamine release and an acute …
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Studies in cardiomyopathy: looking beyond the familiar
… characteristics, natural history and outcomes of cardiomyopathy amongst Africans. Familial aggregation of cardiomyopathy has not been studied systematically in an African setting. Further, it is not clear whether the various phenotypic expressions of cardiomyopathy represent disparate clinical …
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The role of melatonin in peripartum cardiomyopathy
Peripartum cardiomyopathy (PPCM) is a heart disease of unknown aetiology emerging in previously healthy women towards the end of pregnancy or first postpartum months. Previous studies have suggested that oxidative stress contributes to the pathogenesis of PPCM. Melatonin is a powerful endogenous …
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Prevalence of Cardiomyopathy in Apparently Healthy Cats
Subclinical cardiomyopathy (CM) sometimes is identified after abnormalities are detected during auscultation of apparently healthy cats. Little is known regarding the prevalence of CM in this population. Furthermore, the clinical importance of auscultatory abnormalities in apparently healthy cats …
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Role of T Lymphocyte Trafficking in Diabetic Cardiomyopathy
<p>Diabetic cardiomyopathy is a distinct pathological condition characterized by myocardial fibrosis and cardiac dysfunction in diabetic patients. The resolution of myocardial fibrosis to improve cardiac function in diabetes is an active area of research. Notably, increased T lymphocyte …
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Arrhythmogenic Right Ventricular Cardiomyopathy: From Surviving to Thriving
Arrhythmogenic right ventricular cardiomyopathy is a life-threatening, inherited disease, and a leading cause of sudden cardiac death in young, otherwise healthy adolescents and adults. Through the advances of modern technology, those who receive this once-devastating diagnosis, now stand an …
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PATHOGENIC MECHANISMS OF TRUNCATED TITIN IN DILATED CARDIOMYOPATHY
… (TTNtv) have long been known to cause dilated cardiomyopathy (DCM) and, recently, peripartum cardiomyopathy (PPCM). How these genetic variations lead to the hypocontractility that is characteristic of DCM and PPCM has remained controversial due to lack of evidence supporting either …
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Cardiac Vasoactive Peptides in Hypertrophic Cardiomyopathy of Cats
In conclusion, ANP and BNP are normally produced and stored in the atria. With HCM, significant peptide and mRNA expression of BNP is found in the ventricles, while protein and gene expression of ANP remains mainly in the atria. This pattern agrees with increases in plasma concentrations of both …
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Analysis of desmoplakin in arrythmogenic right ventricular cardiomyopathy
It has been shown that all forms of cardiomyopathy, including the dilated, hypertrophic, restrictive, and right ventricular arrhythmogenic forms, are found in African populations. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare muscle disease characterised by fibrofatty replacement …
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Whole-exome sequencing of cases with familial cardiomyopathy
… include dilated, hypertrophic and arrhythmogenic cardiomyopathy (DCM, HCM and ACM respectively). As heterogeneous disorders, over 50 genes have been implicated in these cardiomyopathies to date. However, the yield of genetic testing ranges from less than 40% in idiopathic DCM to over 50% in ACM …
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Mechanism of Atrial Fibrillation in Lamin A/C Cardiomyopathy
Atrial fibrillation (AF) is a common arrhythmia with a complex genetic basis, yet the molecular mechanisms linking rare and common variants remain unclear. Polygenic risk score (PRS) assessment in the UK Biobank and All of Us cohorts shows that the risk of incident AF in carriers of …
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The Role of ECSIT in Mitochondrial Dysfunction Mediated Cardiomyopathy
… in ECSIT which resulted in a hypertrophic cardiomyopathy phenotype in homozygous mutant animals. Further investigation revealed this phenotype to be a result of a loss of function in ECSIT’s role as a complex I assembly factor. Mitochondria from EcsitN209I/N209I hearts showed a reduction in …
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Redefinition of uraemic cardiomyopathy with cardiac magnetic resonance imaging
… with poor prognosis is the presence of uraemic cardiomyopathy, found in approximately 70% of ESRD patients at initiation of dialysis therapy, usually defined echocardiographically as the presence of left ventricular (LV) abnormalities, including left ventricular hypertrophy (LVH), LV dilatation …
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Surgical ventricular reconstruction for ischemic or idiopathic dilated cardiomyopathy
… application to patients with idiopathic dilated cardiomyopathy (DCM). The purpose of this retrospective study was to analyze the clinical outcome and long-term survival of patients who underwent the Dor surgical ventricular reconstruction (SVR) procedure. <br>Methods: Mortality, cardiac function, …
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Cellular mechanism of contractile dysfunction in diabetes-induced cardiomyopathy
… in the streptozotocin-induced (type 1) diabetic cardiomyopathy compared to age-matched control heart. Human and animal studies have shown that diabetes mellitus can be associated with altered cardiac function that is independent of vascular complications. The effects of increased extracellular …
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