Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 241 for “"Cardiomyocytes"”.
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An in Vitro Study of Cellular Cardiomyoplasty: Structural and Functional Interactions of Non-cardiomyocytes and Cardiomyocytes
… higher chances for functional coupling with host cardiomyocytes exist for mesenchymal stem cells (MSC), followed by skeletal myoblasts (SKM), and finally cardiac fibroblasts (CF). Second, we studied the effect resulting from factors secreted by (1) donor cells (SKMs or MSCs) and (2) cardiac …
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Modeling oxygen requirements in ischemic cardiomyocytes
… a known metabolic and molecular state of the cardiomyocytes preceding re-oxygenation.
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
<p>Reactive oxygen species are implicated in tissue damage in many cardiovascular diseases. The current study was designed to test the hypothesis that exposure to high inspired oxygen concentrations (100%) damages cardiac mitochondria and that a biogenic response is needed for cell survival. The …
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DIRECT REPROGRAMMING OF HUMAN FIBROBLASTS INTO CARDIOMYOCYTES
… reprogramming of human fibroblasts into induced cardiomyocytes (iCMs) offers a potential therapeutic approach for cardiovascular disease yet hampered by low efficiency of human iCM generation. Here, we established an optimal culture condition by defining a chemically defined media (CDM). In …
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The regulation of protein synthesis in adult rat cardiomyocytes
… tightly regulated under numerous conditions in cardiomyocytes. It can be activated by hormones such as insulin and also by other agents such as phenylephrine (PE) that activates hypertrophy in the heart. Cardiac hypertrophy involves an increase in the muscle mass of the heart, principally in the …
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Prospective Isolation And Characterization Of Mononucleated And Binucleated Cardiomyocytes
Loss of cardiomyocytes through cardiac injury and disease substantially impairs cardiac function. Given that cardiomyocytes permanently exit the cell cycle soon after birth, the heart has traditionally been considered a terminally differentiated organ, and thus unable to effectively regenerate. …
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Mechanically-induced intercellular remodeling of cardiomyocytes by magnetic micromanipulation
… a system for exerting local mechanical forces on cardiomyocytes to study gap junction remodeling and I show that cell-to-cell movement and subsequent remodeling of Cx43 can occur. The system consisted of patterned linear strands on polyacrylamide gels and mechanical stimulation using magnetic …
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DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… which connect plasma membrane of adjacent cardiomyocytes, by propagating action potential throughout the myocardium maintain cardiac synchronous beating and rhythm. Gap junctions have a rapid turnover and impair of gap junction quality control impacts cell-to-cell communication; resulting …
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Intracellular calcium mobilization in cardiomyocytes of rats with experimental diabetes
… and Ca-indicators) and contraction of the cardiomyocytes (measured by a video-edge detector system) were studied in rats with experimental diabetes induced by streptozotocin (STZ). Ryanodine receptor (the calcium release channel) binding and sarcolemmal Na-Ca exchange activity were also …
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Interactions of Cardiomyocytes and Myofibroblasts: An Experimental and Theoretical Model Study
Cardiomyocytes and fibroblasts make up the majority of cells in natural myocardium. While cardiomyocytes are primarily responsible for the mechanical contraction, fibroblasts are responsible for maintaining the extracellular matrix and tissue compliance. In response to pathologies such as …
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THE BIO-MOLECULAR ANALYSIS OF TITANIUM DIOXIDE NANOPARTICLES EXPOSURE ON CARDIOMYOCYTES
The increasing prominence of nanotechnology on the global economy has raised the need to address the safety of nanoparticles (NPs) on humans. However, the increasing large number of NPs required for testing has led to the need for new alternative testing strategies via computational means to …
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Effects of Neonatal Dexamethasone on the Maturation and Endowment of Cardiomyocytes
… increased risk of cardiovascular disease. Cardiomyocytes are the functional unit of the heart and are unique in that they don’t have an infinite proliferative capacity. In fact, soon after birth myocytes exit the cell cycle and become terminally differentiated. It is therefore crucial that …
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Nesfatin-1 Regulation of Cardiovascular Functions in Zebrafish and HL-1 Cardiomyocytes
… physiology. We found that zebrafish cardiomyocytes express NUCB2 mRNA and nesfatin-1-like immunoreactivity. While NUCB2 mRNA was lower in unfed fish at 1 hour post-regular feeding time compared to the fish at 0 hour time point, it was observed that chronic food deprivation did not …
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Characterization of Prolylcarboxypeptidase Expression Pattern in Rat Cardiomyocytes in Nutrition Overload Conditions
… to address our goals: cell culture of rat H9c2 cardiomyocytes, enzymatic assays for detecting plasma and cardiomyocyte PRCP activity, PRCP RNA and protein studies in high glucose and high fatty acid (saturated and unsaturated) conditions, enzymatic assays to detect PRCP-stimulated activation of …
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Effects of Thyroid hormone on Cardiomyocytes and on Glioma differentiation and proliferation
… potential effects of long-term TH treatment on cardiomyocytes and on glioma tumour cell lines. This study employed neonatal cardiomyocytes, 1321N1 cell line, an astrocytoma grade II, and U87MG, a glioblastoma grade IV. Cells were exposed for 2 and 4 days in culture medium deprived of T3 …
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Investigating the effects of enhanced catecholamine stimulation in stem cell-derived cardiomyocytes
… of sympathetic overdrive in stem-cell derived cardiomyocytes, (2) characterise the structural and functional cardiac phenotype (3) evaluate the role of the TGF-β1 in cardiac remodelling. Methods: Pluripotent mouse embryonic stem cells were differentiated, in vitro, into pulsatile …
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Effects of oxygen on embryonic stem proliferation, energetics, and differentiation into cardiomyocytes
… cellular energetics, and differentiation into cardiomyocytes. It was found that undifferentiated mES cells are capable of surviving and proliferating at pO2 conditions in the range of 0-285 mmHg, with only moderately decreased growth at the extremes in pO2 over this range. Oxygen levels had no …
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Development of a bioreactor imaging system for characterizing embryonic stem cell-derived cardiomyocytes
… protocols, current yields of hESC-derived cardiomyocytes (CM) have been low. In the case of hESC-CM, which are inherently electromechanically active, additional forms of inducing a mature cardiac fate have not been fully explored. In order to non-invasively visualize and quantify …
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The role of intracellular Ca2+ in the arrhythmogenic activity of pulmonary vein cardiomyocytes
… the ectopic activity likely originates in the cardiomyocytes that form an external sleeve around the veins, the underlying mechanisms are unknown. Changes in intracellular Ca2+ signalling have been proposed to play an important role in the arrhythmogenic properties of the pulmonary vein. …
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Effects of GATA4-targeted compounds in hypertrophic models of hypoplastic left heart syndrome cardiomyocytes
Synnynnäiset sydänviat kehittyvät sydämen kehityksen aikana ja määritellään syntymähetkellä läsnä oleviksi sydämen rakenteellisiksi poikkeavuuksiksi, joista vasemman sydänpuoliskon vajaakehittyneisyysoireyhtymä (HLHS) edustaa harvinaista mutta hengenvaarallista alatyyppiä. HLHS:lle on ominaista …
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