Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Cardiomyocyte proliferation"”.
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Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules
… the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac damage. Previous high throughput screening studies in our …
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DOES CALCIUM INFLUX THROUGH T-TYPE CALCIUM CHANNEL INDUCE CARDIOMYOCYTE PROLIFERATION?
… treat such chronic disease. Replace the lost cardiomyocyte with new ones could restore cardiac function and reduce mortality. The purpose of this study is to investigate on how TTCCs (T-type calcium channels) affect cardiomyocyte proliferation. In mice after birth, the major TTCC expressed in …
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Investigating the role of macrophages in larval zebrafish heart regeneration
… cell death, manifesting as a region of necrotic cardiomyocytes in the left ventricle. Unfortunately, the human heart is unable to replace these lost cardiomyocytes, and this can lead to heart failure. In contrast, zebrafish can completely regenerate their hearts after cardiac injury via …
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Development of the Clinical Application of miRNA with Proregenerative Effect on the Heart
… in particular hsa-miR-199a-3p, able to stimulate proliferation of cardiomyocytes and, once expressed in the mouse heart using viral vectors, to induce cardiac regeneration after myocardial infarction. Objective: As a first step towards clinical translation, in this study we assess the efficacy of …
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Effect of Maternal Hypoxia on the Cerebral and Cardiac Tissue Remodeling
… in the abnormal cardiac growth pattern and cardiomyocyte proliferation with the aberrant content of fibrillar collagen network in fetal and neonatal hearts. We further explored the direct effect of hypoxia on cardiomyocyte proliferation by using intact fetal hearts ex vivo model and H9c2 …
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Myc and Cyclin T1 co-expression as a therapeutic strategy for cardiac repair following myocardial infarction
… to regenerate itself by promoting endogenous cardiomyocyte proliferation after myocardial infarction (MI), leads to scarring, cell hypertrophy, and loss of contractility in the left ventricle. Driving endogenous cardiomyocyte proliferation is a promising avenue for heart remuscularisation in …
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MEF2-regulated Gtl2-Dio3 noncoding RNAs in cardiac muscle and disease
… on MEF2A in the perinatal heart and in neonatal cardiomyocytes. To determine the specific role in cardiac muscle, I overexpressed selected microRNA mimics in neonatal rat ventricular myocytes (NRVMs). My results showed that miR-410 and miR-495 stimulate cell cycle re-entry and proliferation of …
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Cellular therapy for chronic heart failure: a key role for epicardial fibronectin
Myocardial infarction (MI) results in permanent cardiomyocyte loss, frequently leading to heart failure, with a 50% 5-year mortality. At subacute time points following MI, animal studies have shown ‘remuscularization’ of the damaged heart with human embryonic stem cell (hESC)-derived …
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Investigating CDK9 inhibitor treatment during the innate inflammatory and regenerative response in a zebrafish model of cardiac injury
… zebrafish hearts regenerate following injury via cardiomyocyte proliferation. Prolonged neutrophil retention has been shown to impair cardiomyocyte proliferation and myocardial wound regression following cardiac injury in zebrafish. I therefore hypothesised that CDK9 inhibitor treatment enhances …
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Cellular and Molecular Mechanisms of Cardiac Chamber Maturation in Zebrafish
… system to trace the progeny of zebrafish atrial cardiomyocytes as they expand to form the mature atrial myocardium. By comparing the observed cellular dynamics to those previously mapped in the ventricle, I identified characteristics of chamber development, including wall thickening, wall …
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MEIS1: At the Crossroads Between Metabolic and Cell Cycle Regulation
… post-natal cell cycle exit and quiescence of cardiomyocytes through induction of synergistic cyclin dependent kinase inhibitor families. We demonstrate that both embryonic and adult deletion of Meis1 in cardiomyocytes results in widespread cardiomyocyte proliferation in the adult heart. …
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Heart Regeneration: An Evolutionary Tale
… life, a phenomenon that is mediated through the proliferation of pre-existing cardiomyocytes. The adult mammalian heart lacks any meaningful endogenous regenerative response following injury. However, embryonic mammalian cardiomyocytes are proliferative and exit the cell cycle shortly after …
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Transcriptional Regulation of Neonatal Heart Regeneration and Direct Cardiac Reprogramming
… previously unknown extracellular mediators of cardiomyocyte proliferation, angiogenesis, and fibroblast activation. Furthermore, using single-nucleus RNA sequencing, we mapped the dynamic transcriptional landscape of five distinct cardiomyocyte populations in healthy, injured and regenerating …
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Perinatal Hypoxia Exposure on the Developing Heart: The Role of Endothelin-1
… life. A key process in determining</p> <p>cardiomyocyte endowment, and thus cardiac function, is the period of terminal differentiation. This involves the maturation of cardiomyocytes and is essential to heart development, however acceleration of this process may alter cardiomyocyte …
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Development and assessment of supercharged platelets as a novel drug delivery mechanism for promoting cardiac regeneration
… recovery in the injured heart by promoting cardiomyocyte proliferation and neovascularisation processes. A lentiviral approach was employed for the genetic engineering of megakaryocytes, the precursor cells of platelets. Lentiviral plasmids, designed for the targeted delivery of proteins to …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… heart, ROS modulates cardiac differentiation, cardiomyocyte proliferation, and myocardial tissue growth via ROS-sensitive protein kinases such as the mitogen-activated protein kinase (MAPK). Although there are several different MAPKs, the p38 MAPKs are involved in cardiogenesis and implicated …
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Development of cardiac patches using medium chain length polyhydroxyalkanoates for cardiac tissue engineering
… human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) on them. The cells were found to be viable and healthy with comparable beating rates and calcium transients to that measured on gelatin which was used as the positive control. The cell alignment quantification on the …