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Showing 1 to 4 of 4 for “"Cardiomyocyte maturation"”.
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Cellular therapy for chronic heart failure: a key role for epicardial fibronectin
Myocardial infarction (MI) results in permanent cardiomyocyte loss, frequently leading to heart failure, with a 50% 5-year mortality. At subacute time points following MI, animal studies have shown ‘remuscularization’ of the damaged heart with human embryonic stem cell (hESC)-derived …
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Prospective Isolation And Characterization Of Mononucleated And Binucleated Cardiomyocytes
Loss of cardiomyocytes through cardiac injury and disease substantially impairs cardiac function. Given that cardiomyocytes permanently exit the cell cycle soon after birth, the heart has traditionally been considered a terminally differentiated organ, and thus unable to effectively regenerate. …
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Perinatal Hypoxia Exposure on the Developing Heart: The Role of Endothelin-1
… life. A key process in determining</p> <p>cardiomyocyte endowment, and thus cardiac function, is the period of terminal differentiation. This involves the maturation of cardiomyocytes and is essential to heart development, however acceleration of this process may alter cardiomyocyte …
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The Epicardium as the Conductor of Cardiovascular Cells in Cardiac Regeneration
… cardiac repair remain, including cell survival, maturation, graft size, revascularisation, and immunogenicity. It has recently been shown that co-transplantation of human embryonic stem cell (hESC)-derived epicardial cells (EPI) with hESC-derived cardiomyocytes (CM) improves cardiac repair …