Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 140 for “"Cardiomyocyte"”.
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Cardiomyocyte Cell Cycle, Renewal and Isolation
Heart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. In paper I, the focus is on the …
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Cardiac Calsequestrin Phosphorylation And Trafficking In The Mammalian Cardiomyocyte
… a juxtanuclear localization of rough ER in cardiomyocytes. Using fluorescence confocal microscopy, the translocon complex proteins TRAP-α and TRAM, along with the ribosomal protein S6, were all visualized and found to encapsulate both myonuclei. Additionally, time course studies of …
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Doxorubicin Inhibits Cardiomyocyte Autophagic Flux by Suppressing Lysosomal Acidification
… multiple assays I showed that doxorubicin blocks cardiomyocyte autophagic flux in vivo and in cardiomyocytes in culture. This block was accompanied by robust accumulation of undegraded autolysosomes. Moreover, I went on to localize the site of block as a defect in lysosome acidification. To test …
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Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules
… identified a series of microRNAs able to trigger cardiomyocyte proliferation and stimulate cardiac regeneration after myocardial infarction. In the first part of this project, we investigated the mechanism of action of the top ten most effective of these miRNAs, revealing an involvement of the …
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Congenital Heart Defect-Associated Enhancers Shape Human Cardiomyocyte Lineage Commitment
Pages vii-xiv are misnumbered as pages vi-xiii.
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Cardiomyocyte Autophagy Is Induced by Protein Aggregation in Heart Disease
… protein aggregation to increased cardiomyocyte autophagy. Specifically, in the pressure-stressed ventricle 1) generation of reactive oxygen species is an early pathological event, 2) there is extensive protein aggregation with higher-order processing into aggresomes, 3) protein …
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
… and anti-hypertrophic effects respectively, in cardiomyocytes. We sought to determine the direct interaction between the adipocytes and cardiomyocytes during endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and determine the role of leptin and adiponectin. The adipose tissue conditioned …
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DOES CALCIUM INFLUX THROUGH T-TYPE CALCIUM CHANNEL INDUCE CARDIOMYOCYTE PROLIFERATION?
… treat such chronic disease. Replace the lost cardiomyocyte with new ones could restore cardiac function and reduce mortality. The purpose of this study is to investigate on how TTCCs (T-type calcium channels) affect cardiomyocyte proliferation. In mice after birth, the major TTCC expressed in …
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Pathophysiological changes in cardiomyocyte metabolism and bioenergetics during stress-induced cardiomyopathy.
… focused on metabolic and bioenergetic changes in cardiomyocytes during stress exposure. Stress exposure leads to pathophysiological changes in myocardium, which can lead to heart failure. It is important to know exact pathophysiological changes to prevent the development of heart failure. The main …
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Cardiomyocyte-Specific Deficiency of Ketone Body Metabolism Promotes Accelerated Pathological Remodeling
… die in the early postnatal period, mice with cardiomyocyte-specific loss of SCOT (SCOT-Heart-KO) exhibit no overt metabolic abnormalities, and no differences in left ventricular mass or impairments of systolic function during periods of ketosis, including fasting and adherence to ketogenic …
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RalGDS-Dependent Cardiomyocyte Autophagy Is Necessary for Load-Induced Ventricular Hypertrophy
… in numerous cellular processes, yet its role in cardiomyocyte plasticity is unknown. Here, I set out to explore the role of small G protein-dependent membrane trafficking in stress-induced cardiomyocyte remodeling and autophagy. To explore underlying mechanisms, I tested in cultured neonatal …
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Collagen-Glycosaminoglycan Scaffold Systems to Assess HL-1 Cardiomyocyte Beating and Alignment
… pore structures promoted spontaneous HL-1 cardiomyocyte beating compared to isotropic controls. This effect was dependent on pore size, with scaffolds with larger mean pore sizes exhibiting the highest instances of spontaneous beating. In addition, anisotropic scaffold variants promoted …
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Biochemical effects of organophosphorous compounds on cultured rat and human cardiomyocyte-like cells
… of organophosphorous compounds (OPs) on cardiomyocytes. The present study aimed to investigate the effects of phenyl saligenin phosphate (PSP), two organophosphorothioate insecticides (diazinon and chlorpyrifos), and their acutely toxic metabolites (diazoxon and chlorpyrifos oxon) on rat …
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LONG NON-CODING RNA VENTHEART IS NECESSARY FOR VENTRICULAR CARDIOMYOCYTE SPECIFICATION AND FUNCTION
… as one of the top upregulated markers in cardiomyocyte (CM) development. Utilizing human pluripotent stem cell-derived cardiomyocytes (hPSC-CM) as an in vitro model for cardiac differentiation and development, VHRT was found to be highly co-regulated with crucial cardiac and …
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Angiotensin-(1-9) prevents cardiomyocyte hypertrophy via miR-129-3p/PKIA/PKA signaling pathway
… system with anti-hypertrophic effects in cardiomyocytes via an unknown mechanism. Our previous work proved that this peptide induces mitochondrial fusion through Drp1 phosphorylation and prevented norepinephrine-elicited mitochondrial fission. In the present work, we aimed to elucidate the …
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Gender Differences In Cardiomyocyte Remodeling and Adhesion In Response to Chronic Elevations In Myocardial Stress
… to determine whether gender difference exists in cardiomyocyte remodeling during chronic volume overload (CVO) induced by aortocaval (AV) fistula. To this end, isolated cardiomyocyte dimension, sarcomere length, number of nuclei were measured in male and female rats after creation of an AV …
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The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
… injury. I utilized a doxycycline-inducible, cardiomyocyte-specific, constitutively-active FGF receptor (caFGFR1) mouse model to test whether the cardiomyocyte has the capacity to respond to a cell autonomous FGF signal. Induction of this transgene led to immediate changes in cardiac …
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Effects of the MYH7 R369Q Dilated Cardiomyopathy-causing Mutation on Myosin Crossbridge Kinetics and Cardiomyocyte Contractility
… alter actin-myosin interaction that facilitates cardiomyocyte contraction. There are limited insights into the nature and implications of this mutation on the contractile system within a cardiomyocyte that results in hypocontractility. To better understand the biochemical and biophysical effects …
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Comparison of dispersion metrics for estimating transcriptional noise in single-cell RNA-seq data and applications to cardiomyocyte biology
Transcription is a dynamic process with a multitude of characteristics, including transcript level, burst frequency, amplitude, and variability. Single-cell RNA sequencing data analysis often focuses on comparing transcription levels. However, these analyses capture only a portion of the wealth of …
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Effects of Neonatal Dexamethasone on the Maturation and Endowment of Cardiomyocytes
… increased risk of cardiovascular disease. Cardiomyocytes are the functional unit of the heart and are unique in that they don’t have an infinite proliferative capacity. In fact, soon after birth myocytes exit the cell cycle and become terminally differentiated. It is therefore crucial that …
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