Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 50 for “"Cardiometabolic Disease"”.
-
INVESTIGATION OF THE GENETIC ARCHITECTURE OF CARDIOMETABOLIC DISEASE
Cardiometabolic syndrome (CMS) is a clustering of interrelated risk factors (central obesity, hyperglycemia, hypertension, insulin resistance, and dyslipoproteinemia) that promotes the development of atherosclerotic vascular disease and type 2 diabetes. It was recognized as a disease entity by the …
-
Investigating the Relationship between Markers of Ageing and Cardiometabolic Disease
Human ageing is accompanied by characteristic metabolic and endocrine changes, including altered hormone profiles, insulin resistance and deterioration of skeletal muscle. Obesity and diabetes may themselves drive an accelerated ageing phenotype. Untangling the causal web between ageing, obesity …
-
Sleep characteristics and cardiometabolic disease risk factors in corporate executives
… deaths globally are related to non-communicable diseases (NCDs), most of which are attributed to cardiometabolic diseases (CMD). While there is clear evidence linking short sleep duration with CMD risk in the general population, similar data in a unique subset of the workforce, namely corporate …
-
Risk factors for cardiometabolic disease among children in South East Asia
… objectives: The current and projected burden of cardiometabolic diseases in Asia is high, with a notable and rapidly increasing prevalence of associated risk factors among children in this region. Comprehensive evidence on cardiometabolic disease risk factors among children in Asia is required to …
-
Peripheral Vascular Function in Young Adults with Increased Risk of Cardiometabolic Disease
<p>Objective: To determine if young adults with elevated metabolic syndrome severity scores (MetS<sub>index</sub>) suffer from peripheral vasculature dysfunction.</p> <p>Methods: Mean arterial pressure (MAP), Femoral (FBF) and Brachial Blood flow (BBF), Femoral (FVC) and Brachial Vascular …
-
A comparative evaluation of surrogate measures of adiposity as indictors of cardiometabolic disease
… diabetes, and those at increased obesity-related cardiometabolic risk. In particular, it aimed to determine how useful surrogate measures of adiposity might be to identify high-risk patients within a clinical setting. Using a cross-sectional sample of 2,047 middle-aged men and women, the main …
-
Evidence for the role of delta-6-desaturase in the development of cardiometabolic disease
… delta-6-desaturase (D6D) in the development of cardiometabolic disease. The experiments tested the general hypothesis that changes in fatty acid membrane composition found to be associated with cardiometabolic disease are attributed to delta-6-desaturase activity and contribute to the …
-
Risk factors for cardiometabolic disease in the eThekwini Municipality (City of Durban), South Africa.
Background: The burden of cardiometabolic disease (CMD) is rising in sub-Saharan Africa (SSA). However, there are limited population-based prevalence estimates of CMD risk factors to inform public health initiatives for the prevention and management of CMDs in these populations. This thesis aims to …
-
Temporal changes in the cardiometabolic disease risk profile of the Bellville south mixed-ancestry community between 2008/09 AND 2014/16
Background/purpose: The burden of cardiovascular disease (CVD) is growing rapidly and has shifted from high-income countries to low-middle income countries, including South Africa. In the South African Mixed-ancestry population, there is a dearth of trend studies examining the changes in …
-
Physical activity, sedentary behaviour and cardiometabolic disease risk among adults living with obstructive sleep apnoea: Is there a case for exercise as an adjunct therapy?
… sleep quality, have emerged as being related to cardiometabolic disease (CMD) risk, including obesity, hypertension, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD). Obstructive sleep apnoea (OSA) is the second most common sleep disorder and is characterized by multiple …
-
Environmental Arsenic Exposure and Risk of Cardiovascular Disease
… and skin lesions, research on arsenic-related cardiometabolic disease, particularly at lower exposure levels, has been limited. This PhD thesis aims to investigate the epidemiological relationship between chronic environmental arsenic exposure and several sub-types of cardiometabolic disease, …
-
Epidemiological Investigations of Dietary Patterns and Physical Activity on Longevity and the Risk of Cardiovascular Disease and Diabetes
… for premature mortality and major chronic diseases, such as cardiovascular disease (CVD) and type 2 diabetes (diabetes). However, few large-scale studies have examined the combined influence of overall diet quality and physical activity on longevity and the risk of clinically-diagnosed CVD …
-
Time-Restricted Eating and Prebiotic Supplementation in Young Adult Pediatric Cancer Survivors
… long term remission, PCS experience chronic disease at an earlier age than matched controls which may be a result of increased biological aging, or inflammaging, in this population. Anti-cancer treatment may initiate inflammaging promoting systemic inflammation and gut dysbiosis and …
-
Investigating systemic effects of chronic stress on hepatic and cardiac tissue in female Wistar rats
Chronic psychosocial stress contributes to cardiometabolic disease onset and progression through various mechanisms including through HPA-axis dysregulation, inflammation, oxidative stress, and autophagic impairment. Growing evidence suggests females may be disproportionately vulnerable to these …
-
The Impact of Metals and Metal Mixtures on Cardiometabolic Health among Hispanics/Latinos
… to many negative health consequences including cardiometabolic diseases. Cardiometabolic diseases including diabetes and hypertension, impact two-thirds of people in the United States and are among the leading causes of death worldwide. Importantly, these conditions do not impact all individuals …
-
Examining the Impact of PUFAs and the Role of Autophagy in Iron-Induced Ferroptotic Cell Death
… involves lipid peroxidation and associates with cardiometabolic disease and cancer. I established a model of iron overload in L6 cells and measured cell viability, toxicity and lipid peroxidation. Importantly, in PUFA pre-treated cells, the susceptibility to iron-induced lipid peroxidation was …
-
Chronic Circadian Disruption Alters Behaviour, Cardiac Function and Glucose Regulation in Mice
… circadian misalignment in mammals contributes to cardiometabolic disease and stress-induced emotional disorders. The BTBR mouse strain shows several abnormalities, including insulin resistance, enlarged hearts, short circadian periods (22.75 hrs), and high stress reactivity. Whether these traits …
-
The Assessment of Autonomic Function in Young Adults with an Elevated Risk of Metabolic Syndrome
… defined by the co-occurrence of multiple cardiometabolic risk factors. Despite the well-defined profile of autonomic function in individuals with MetS, autonomic function in those with an elevated risk of developing MetS remains unclear. Our study aimed to shed light on the progression of …
-
Understanding Temporal Movement Behaviour Patterns: Measurement, Epidemiology, and Cardiometabolic Health Implications
… the independent role of movement patterns in cardiometabolic health, beyond total physical activity energy expenditure (PAEE), remains unclear. This thesis aimed to: (1) review and categorise metrics and methods used to describe temporal movement behaviour patterns measured by wearables, and …
Page 1 of 3