Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Cardiology and Cardiovascular Disease"”.
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Incidence of heart failure in an urban population
… to immigrant status, biological, life style and socioeconomic risk factors. The thesis is based on four papers. Paper I included inhabitants (N=114,917; aged 40-89 years) in the city of Malmö, Sweden, followed from November 1st, 1990 until December 31st, 2007. Paper II-IV used the …
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Clinical and Biological Aspects of Cardiovascular microRNA
Ischemic heart disease is the leading cause of death in high-income parts of the world and is caused mainly by atherosclerosis in the coronary arteries. The rupture of an atherosclerotic plaque with subsequent platelet activation and clot formation can lead to myocardial infarction (MI). …
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Lyso-PC and macrophage interplay. Scavenging through the fatty side of atherosclerosis
… by LDL entrapment in the vessel wall. Oxidation and enzymatic processing of LDL give rise to inflammatory mediators such as lyso-PC. These inflammatory mediators attract monocytes into the vessel wall where they differentiate into macrophages. The macrophages adopt different phenotypes depending …
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Electrocardiographic predictors of clinical outcome in ST-elevation myocardial infarction
… calculated using conventional ECG recording and can predict the degree of myocardial injury and impending VF, is promising. This work is aimed at investigating cardiac repolarization and depolarization abnormalities and predictors and prognosis of ventricular arrhythmias during the course of …
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Lipid Micro Emboli in Cardiac Surgery
… by the cardiotomy suction, through filters and the plastic tubing in the cardiopulmonary bypass (CPB) circuit. The lipid particles are quite probably in an emulsified state which renders them hydrophilic and less prone to stick to the plastic surfaces of tubing and filters. With a series of …
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Alternative Lead Systems for Diagnostic Electrocardiography: Validation and Clinical Applicability
The standard 12-lead electrocardiogram (ECG) remains one of the most important and most frequently used tools for diagnosing cardiac diseases, although several different examination modalities in cardio¬logy have been developed over the years. The standard ECG uses 10 electrodes placed on …
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Protective Immunity in Atherosclerosis
… for novel therapies that are aiming at reducing cardiovascular diseases. Autoimmune responses against modified low density lipoprotein (LDL) are believed to promote development of atherosclerosis. Proinflammatory immune responses can be counterbalanced by immunosuppressive regulatory T cells …
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Immune Responses Aginst Aldehyde Modified Extracellular Matrix in Atherosclerosis
Atherosclerosis is a chronic inflammatory disease and the leading cause of myocardial infarction and stroke. Accumulation, aggregation and subsequent oxidation of LDL in the arterial wall are considered as key events in the development of atherosclerosis. The oxidation of LDL generates reactive …
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Hypothermia as an adjunctive therapy in Acute Myocardial Infarction and Cardiogenic Shock
… soon as possible in order to reduce infarct size and associated complications. Hypothermia has in experimental studies been shown to reduce infarct size. Clinical trials, however, have not been able to show this effect, possibly because a therapeutic temperature was not reached before reperfusion …
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Novel Agonists and Antagonists of Platelet Receptors
… P2Y12 is a key receptor for platelet activation, and thus for thrombus formation, which makes P2Y12 a target in pharmaceutical antiplatelet therapies. As a complement during revascularization surgery, mild hypothermia has been accepted, but its effect on platelet activation is unclear. We …
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Ultrasound-enhanced Fibrinolysis Pro-fibrinolytic and Non-beneficial Effects Of Ultrasound Exposure
… to further clarify the pro-fibrinolytic effects, and to explore the possible non-beneficial effects in ischemic organs, during exposure to pulsed ultrasound. This was accomplished by studies of the effects of different intensities of pulsed ultrasound exposure on the fibrinolytic properties of …
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Genetic characterization of families with von Willebrand disease
von Willebrand disease (VWD) is the most common hereditary bleeding disorder. It is caused by quantitative and/or qualitative defects of the von Willebrand factor (VWF). The severity of the disease can vary considerably, as can the hereditary patterns. The variable phenotypes of VWD have given rise …
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Oral anticoagulation treatment in atrial fibrillation - To bleed or not to bleed, that is the question
… with warfarin have a narrow therapeutic window and patients exhibit a highly variable doseresponse that is attributable to genetic, disease-related,and environmental factors as well as prescription and nonprescription drugs, dietary vitamin K and alcohol. The effect of warfarin treatement on …
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ADP regulation of insulin secretion and beta-cell apoptosis
… of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in …
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Population-based prediction of atrial fibrillation
… is the most common sustained cardiac arrhythmia and increases in prevalence. As AF confers increased risk of morbidity, stroke, dementia and mortality, a major objective of cardiovascular epidemiology today is the development of tools for prediction and prevention of AF and its consequences. …
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Cardioprotective treatment strategies
… activation, tissue plasminogen activator (t-PA) and extracellular adenosine triphosphate (ATP) release contribute to myocardial injury. ATP is degraded into adenosine by the enzyme apyrase, and adenosine possesses cardioprotective properties. ADC-1004 is an antagonist of the receptor to the …
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Clinical probability assessment and biochemical markers in the diagnosis of deep vein thrombosis
… of pre-test clinical probability assessment and D-dimer test is now widely applied in the diagnostic process of DVT. The general objective of the present investigation was to validate these results in a Swedish routine emergency setting were the prevalence of the disease is high and were the …
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Importance of renal function in cardiac surgery
Abstract Acute kidney injury (AKI) is a common and serious complication after cardiothoracic surgery and is associated with increased short- and long-term mortality risk. Despite extensive studies in the field, a comprehensive understanding of this syndrome has remained elusive, partly due to …
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Myocardial Topical Negative Pressure
… flow, to stimulate granulation tissue formation, and to stimulate angiogenesis in the underlying tissue, mainly subcutaneous tissue and skeletal muscle. It was concluded that topical negative pressure of -50 mmHg applied over the LAD region induced a significant increase not only in local …
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Negative Pressure Wound Therapy - Mechanisms of Action and Protecting Exposed Blood Vessels in the Wound Bed
… been associated with severe complications and bleeding when used in wounds with exposed blood vessels. The aims of this work were to investigate the mechanisms of action of NPWT and to explore the possibility of using thin plastic discs to protect exposed blood vessels in the wound bed …
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