Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Cardiolipin"”.
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Identification and characterisation of cardiolipin autoantibodies
… to develop a method to isolate and identify anticardiolipin antibodies found in human serum samples obtained from patients with antiphospholipid syndrome (APS) APS is a disorder with clinical manifestations that include venous and arterial thromboembolism, thrombocytopenia, recurrent spontaneous …
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The temporal relationship between cardiolipin biosynthesis and remodeling enzymes and cardiolipin content during unloading atrophy in mouse soleus
… specifically the mitochondrially exclusive cardiolipin (CL). CL biosynthesis results in nascent CL which must be remodeled by tafazzin (Taz) to form the predominant CL species in mammals, tetralinoleoyl cardiolipin (TLCL). Previous research has shown that CL content and 18:2n6 composition …
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Cardiolipin Regulates Mitophagy Through The Pkc Pathway
<p>Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is important for cardiovascular health. Perturbation of CL metabolism is implicated in cardiovascular disease (CVD). The link between CL and CVD may be explained by the physiological roles of CL in pathways that are …
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The Role Of Cardiolipin In Iron Homeostasis And Glutathione Metabolism
<p>Cardiolipin (CL) is the signature phospholipid of mitochondrial membranes, where it is synthesized locally and plays a critical role in mitochondrial bioenergetic functions. Inside the mitochondria, CL is a critical target of mitochondrial generated reactive oxygen species (ROS) and regulates …
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The role of cardiolipin in the regulation of mitochondria-dependent apoptosis
… pathway and is often inhibited in cancer. Cardiolipin (CL) is a mitochondria-specific phospholipid that contains four acyl-chains. CL has been implicated in many of the mitochondria-dependent steps that lead to the release of apoptogenic factors including interaction with the Bcl-2 family …
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Identification of cellular functions of cardiolipin as physiological modifiers of barth syndrome
<p>Cardiolipin (CL) is an anionic phospholipid synthesized in the mitochondrial inner membrane. Perturbation of CL metabolism leads to Barth syndrome (BTHS), a life threatening genetic disorder. I utilized genetic, biochemical and cell biological approaches in yeast to elucidate the cellular …
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SERUM ANTI-PHOSPHORYLCHOLINE AND ANTI-CARDIOLIPIN CONCENTRATIONS FOLLOWING PERIODONTAL SCALING AND ROOT PLANING
… antigens such as phosphorylcholine (PC) and cardiolipin (CL) show opsonizing cross-reactivity with oxLDL it can be proposed that there is a link between immune responses to periodontal bacteria and atherosclerosis. The aim of this investigation was to determine whether periodontal bacteria …
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The structural effects of divalent cations and insulin on phospholipid model membranes /
… using the technique of x-ray diffraction. Cardiolipin, precipitated from dilute solution by divalent ionscalcium, magnesium and barium, contains little water and the structure formed is similar to the structure of pure cardiolipin with low water content. The calcium-cardiolipin complex …
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Mitochondrial structure and distribution in Saccharomyces cerevisiae
… of the mitochondrial signature lipid cardiolipin. This work assigns a specific process to each of the three genes and provides evidence how these processes influence mitochondrial behavior. In summary, this study elucidates how various processes influence the fusion and fission of a …
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Mitochondrial Structure-Function in health and disease
… the role of cristae-shaping factors like cardiolipin in health and disease. In a series of studies, we tested the effects of the cell-permeable tetrapeptides, elamipretide and a postulated peptide, (arginine-tyrosine-lysine-phenylalanine; "RYKF"), on the recovery of mitochondrial …
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Molecular Basis of Cell Membrane Adaption Against Daptomycin in Enterococcus faecalis
… LiaFSR, with a possible contribution of cardiolipin synthase (Cls) (Cesar A Arias et al., 2011a; Khan et al., 2019b; Palmer et al., 2011a; Panesso et al., 2015a; Reyes et al., 2015a). However, the mechanism by which LiaFSR controls the cell membrane response and the role of Cls are …
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INTRA-MITOCHONDRIAL INJURY DURING ISCHEMIA-REPERFUSION
… pathological role of cytochrome c in depleting cardiolipin during ischemia after which the mitochondria are in a defective condition that leads to additional cell death during reperfusion. During ischemia oxidants from complex III oxidize cytochrome c, forming a peroxidase, which causes …
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Structure & Function of Bacterial Transport Machines in their Cellular Context
… has an asymmetric preferential interaction with cardiolipin when its substrate is present, which is not seen in the peptidase simulations. I propose that this preference is part of the mechanism of transport, with cardiolipin providing energy via the proton-motive force. I test this hypothesis …
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Insights into the Synthesis, Mechanism of Action, and Biosynthesis of a Novel Lipodepsipeptide Antibiotic, WAP-8294A2
… but not for binding to the membrane phospholipid cardiolipin. </p><p> Additionally, we developed a method to improve the production, isolation, and purification of the WAP-8294A antibiotic complex highly enriched in the A2 fraction. The antibiotic complex was analyzed for antibiotic activity and …
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Discovery and characterization of ribosomally synthesized and post-translationally modified peptide natural products
… be dependent on the diphosphatidylglycerol lipid cardiolipin. PZN is thought to localize to weakened sections of the B. anthracis membrane that contain aggregates of cardiolipin. These lipid aggregates create regions of membrane instability in B. anthracis, and PZN is able to insert into these …
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An Integrated Omics Approach to Define the Molecular Mechanisms of Low Dose, High Charge, High Energy Irradiation (HZE) in Liver
… Complex I activity, mitochondria count and cardiolipin levels were also used as validation of these findings. Significant decreases were seen in Complex I activity and while not significant, changes were also seen in the mitochondria number and cardiolipin levels that also support …
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The role of phospholipids in the growth and development of Streptomyces
… and SCO6468. SCO1389 is predicted to encode a cardiolipin synthase that is an essential gene in this organism. When this gene was placed under the control of an inducible promoter, the strain developed poorly on agar, unless supplemented with the inducer of the promoter. We demonstrated that …
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Innate and humoral immune responses to HIV-1
… 4E10 autoantigen was the mitochondrial lipid cardiolipin. However, using carefully-controlled assays, 4E10 bound only weakly to cardiolipin-containing liposomes, but also bound negatively-charged, non-cardiolipin-containing liposomes comparably poorly. 4E10/liposome binding was predominantly …
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