Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Cardiac structure and function"”.
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Cardiac Structure and Function in Young Athletes
… of a long-term endurance-training on resting and exercising cardiac responses on male adolescents. The sample consisted of 13 endurance-trained and 7 non-athletic male adolescents (x +\- SE, age = 15.33 +/- 0.33 and 15.15 +/- 0.23 years, respectively). The volunteers underwent echocardiography …
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The impact of morbid obesity on cardiac structure and function in pregnancy
… is a major threat to global health. Structural and functional changes in the heart are well documented for obesity as well as for pregnancy, but there is limited literature on the impact of obesity on cardiac function in pregnancy. We hypothesized that cardiac maladaptation to pregnancy occurs …
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Quantification of cardiac structure and function using transthoracic echocardiography in term women with HIV
… are human immunodeficiency virus (HIV) positive and morbidity and mortality is high in this group. HIV positive men and women may have multiple cardiovascular comorbidities, which include systolic dysfunction that may progress to heart failure secondary to dilated cardiomyopathy. However the …
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The impact of ageing and exercise training on cardiac structure and function in healthy females
… With ageing comes a significant reduction in functional capacity, cardiovascular function, increased cardiovascular disease risk and thus increasing health care costs. Exercise interventions in the elderly may prove to be a valuable tool in coping with an ageing population. It was, therefore, …
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Chronic Treatment of TMAO Undermines Mouse Cardiac Structure and Function in a Sex-specific Manner
… disease (CVD) is a major cause of mortality and morbidity worldwide, often with heart failure as the terminal stage. Clinical studies have associated elevated levels of trimethylamine N-oxide (TMAO), a gut-derived metabolite, with adverse outcomes of CVD. As of today, TMAO's effects on …
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New Advances on the Biochemical Pathways in the Reninangiotensin System in Hypertension and their role in Cardiac Structure and Function
… cause of mortality both in the United States, and worldwide. Two of the most recognized contributing risk factors to the progression of cardiovascular disease and heart failure are hyperension and cardiac hypertrophy. Although the incidence of heart disease has been declining since 1999, it is …
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Early Outgrowth Cells As A Novel Therapy for Chronic Kidney Disease
Chronic kidney disease (CKD) and its cardiac complications represent a large and growing problem in Canada. The progression of CKD is driven by the activation of several final common pathways of injury, including fibrosis and oxidative stress. If left unchecked, these inter-connected processes lead …
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Dobutamine stress magnetic resonance imaging in tetralogy of fallot
This thesis evaluates the role of cardiac magnetic resonance (CMR) imaging in the assessment of patients with surgically repaired tetralogy of Fallot (TOF). CMR has become a powerful tool in the serial assessment of this group of patients and provides important information on cardiac structure and …
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The Efficacy Of Prostaglandin Synthase Inhibition On Attenuating Pressure Overload Induced Cardiac Remodeling
… inflammation as the pathological driver of cardiac remodeling, the exact mechanistic pathway associated with pressure overload-induced cardiac remodeling remains to be elucidated. In order to address this issue, we designed this study to determine pathways associated with pressure overload …
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Magnetic Resonance Imaging of the Heart and Vasculature at 3 Tesla: Novel Strategies for the Diagnosis and Risk Stratification of Cardiovascular Disease
… (1) To study the effects of field strength and parallel imaging on image contrast and the interstudy reproducibility of right and left ventricular (RV and LV) measurements using steady-state free precession (SSFP) cardiac magnetic resonance; (2) to explore the impact of 3T parallel imaging …
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Spectrum of sub-clinical cardiovascular diseases among adult patients with diabetes in out-patient clinic at the University Teaching Hospital in Zambia
… disease, the major cause of mortality and morbidity in modern societies, is set to overtake infectious diseases in the developing world as the most common cause of death. The increasing prevalence of major and emerging cardiovascular risk factors accounts for this growing burden. …
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High-field Cardiac Magnetic Resonance Imaging in Small Animal Models of Cardiovascular Disease
… infarction (MI), pulmonary hypertension (PH), and cardiomyopathy belong to a class of diseases collectively described as cardiovascular disease, the leading cause of death worldwide. Assessment of the left and right ventricular (LV, RV) structural and functional changes concomitant with the …
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The Heart of the Rugby Football League Athlete: An Aid to Pre-Participation Cardiac Screening
Pre-participation cardiac screening (PCS) of the athlete has recently become mandatory by many national and international sporting governing bodies and aims to identify those at risk of sudden cardiac death (SCD) from an undiagnosed cardiac condition. The term athletes’ heart (AH) describes the …
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Cardiovascular consequences of anabolic steroid use
… steroid (AS) use for non-medical performance and image enhancement purposes, the impact of AS on cardiovascular health is an issue of growing public concern. AS use has long been associated with a number of negative CV outcomes such as acute myocardial infarction, stroke, thrombo-embolisms and …
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Evaluation of alterations in cardiovascular structure and function in end-stage renal failure.
Background: Chronic renal dysfunction is associated with myriad alterations in cardiovascular structure and function, resulting in markedly elevated rates of cardiac and vascular morbidity and mortality. Utilising advances in cardiovascular magnetic resonance imaging (CMR), we evaluated the …
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Age-associated changes to calcium handling proteins across the whole heart
Age is a major risk factor for the development of cardiac problems. The ageing process causes significant changes to cardiac structure and function. These are linked with the elderly heart’s diminished ability to respond to cardiac demand and associated with the increased frequency of myocardial …
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Effect of the Pdgfbʳᵉᵗ mutation on cardiovascular homeostasis
… cardiovascular system in development, health, and disease. During angiogenesis PDGFB regulates pericyte migration and proliferation during development and in tissue repair. Pericytes confer vessel stability, maintain vessel integrity, and control vascular tone. In the field of regenerative …
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Targeting macrophages GLP-1 receptor pathways as emerging therapies to ameliorate cardiac remodelling associated with diabetes
The pathophysiological link between diabetes and cardiovascular disease is complex with compelling evidence indicating that hyperglycaemia, as a hallmark of diabetes, induces cardiac abnormalities specifically associated with inflammation, extracellular matrix (ECM) changes, and diastolic …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… cardiomyopathy” describes distinct structural and functional changes in the heart driven by metabolic and microvascular abnormalities. Microvascular dysfunction appears at an early stage as a result of impaired endothelial function, at least in part due to hyperglycaemia-induced production of …
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