Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Cardiac repair"”.
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Electrospun scaffolds incorporating nanoparticles for controlled drug delivery in post-infarction cardiac repair
L'abstract è presente nell'allegato / the abstract is in the attachment
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Dynamics of Endogenous Cardiac Repair and Methods for Enhanced Post-Injury Cell Therapy
… resulting scar. Recent studies revealed modest cardiac regeneration occurring throughout life and accelerating (albeit insufficiently) post-injury. However, the magnitude is contested with some studies indicating low cardiomyocyte formation and others indicating rapid formation of increasingly …
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Engineering Small Extracellular Vesicle-Derived Vehicles Carrying Optimized microRNA for Cardiac Repair after Myocardial Infarction
… (ELV) with select microRNA (miR) cargo for cardiac repair and (2) to understand the role of the sEV membrane on vesicle uptake and ELV functionality. We hypothesized that ELVs comprised of an sEV membrane and loaded with miR cargo will improve cardiac tissue repair after MI compared to sEVs …
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Myc and Cyclin T1 co-expression as a therapeutic strategy for cardiac repair following myocardial infarction
… progression, as well as assess the effect on cardiac repair after MI. The study utilised a combination of genetic mouse models of R26-MycER coupled with Myh6-Cre and Cre mRNA cassette excision and with AVV9-cTnT-Ccnt1 treatment at 4 weeks of age, as well as modified mRNA transfection in adult …
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Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1
… burden. The advancement of treatments to improve cardiac repair post-MI requires the discovery of new targeted treatment strategies. Epicardial-to-mesenchymal transition (EMT) occurs post-MI as a mechanism to support neovascularization and cardiac healing. However, the endogenous EMT is not enough …
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The Epicardium as the Conductor of Cardiovascular Cells in Cardiac Regeneration
Stem cell therapy for cardiac repair is a field of regenerative cardiovascular medicine that is emerging as a promising therapeutic alternative to heart transplantation in patients suffering from chronic heart failure. Although promising, challenges to cell therapy for cardiac repair remain, …
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Investigating CDK9 inhibitor treatment during the innate inflammatory and regenerative response in a zebrafish model of cardiac injury
… are crucial effectors and modulators of cardiac repair following myocardial infarction (MI). Sustained neutrophilic inflammation is detrimental for cardiac repair and associated with adverse MI outcomes. An attractive therapeutic strategy to treat acute inflammatory disorders, such as MI, …
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Transcriptional Regulation of Neonatal Heart Regeneration and Direct Cardiac Reprogramming
… later life may provide novel insights for heart repair. To elucidate the transcriptional responses of the different cellular components of the mouse heart following injury, we performed single cell RNA-sequencing on neonatal hearts at various timepoints following myocardial infarction, and …
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Mesenchymal stem cell therapy for the treatment of myocardial infarction
… (MSCs) are currently under investigation as repair agents in the preservation of cardiac function following myocardial infarction (MI). However concerns have emerged regarding the safety of acute intracoronary (IC) MSC delivery specifically related to mortality, micro-infarction and …
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Novel recombinant protein constructs for improved insulin-like growth factor-1 delivery
… for myocardial delivery of IGF-1 to facilitate cardiac repair.
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Innate Immune Transcription Activator Interferon Regulatory Factor-3 (IRF3) Contributes to Maladaptive Remodeling Post-myocardial Infarction
… response as a positive or negative regulator of cardiac remodeling. Recent data strongly support a role for key regulatory components within the toll-like receptor (TLR) family as potent modulators of cardiac remodeling post-MI. It has been demonstrated that targeted gene knockdown of TLR4, as …
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DOES CALCIUM INFLUX THROUGH T-TYPE CALCIUM CHANNEL INDUCE CARDIOMYOCYTE PROLIFERATION?
… function of the heart due to progressive cardiac myocytes loss. Though after decades of endeavor of searching the pathophysiology and treatments for heart failure, it remains highly lethal. Therefore, it is vital to find novel therapies to help treat such chronic disease. Replace the lost …
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Development of the Clinical Application of miRNA with Proregenerative Effect on the Heart
… the heart and the lack of drugs able to foster cardiac regeneration. Our recent work has identified a few human microRNAs (miRNAs), in particular hsa-miR-199a-3p, able to stimulate proliferation of cardiomyocytes and, once expressed in the mouse heart using viral vectors, to induce cardiac …
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Molecular Regulation of Direct Cardiac Reprogramming
… still the primary cause of death in the world. Cardiac fibroblasts (CFs) constitute ~50% of the cells in the heart and form scar tissue following heart injury. Reprogramming CFs to induced-cardiomyocytes (iCMs) by forced expression of cardiac specific transcription factors holds promise for …
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Development of a cardiac patch for the regeneration of infarcted hearts
The inflammation that occurs after cardiac ischemia/reperfusion leads to high levels of oxidative stress, which produces deleterious effects that ultimately limit regeneration of the myocardium. This stress response can be prolonged, thereby affecting various stages of cardiac repair remodelling. …
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DIABETES IMPAIRS THERAPEUTIC EFFECT OF ENDOTHELIAL PROGENITOR CELL EXOSOME-MEDIATED MYOCARDIAL REPAIR
… endothelial progenitor cells (BM-EPCs) promote cardiac neovascularization and attenuate ischemic injury in animal models. Lately, emerging evidence supports that exosomes (Exo), a family of extracellular vesicles, mediate stem cell therapy by carrying cell-specific biological cargo and by …
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THE ROLE OF CIRCULAR RNA CDR1AS IN MACROPHAGE MEDIATED CARDIAC INJURY AND REPAIR
… infarction is the most common form of acute cardiac injury attributed to heart failure. Despite advancements in prognosis and treatment, acute MI (AMI) still bears a considerable mortality rate within the initial year, with a significant portion of patients succumbing within the initial 30 …