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Showing 1 to 12 of 12 for “"Cardiac metabolism"”.
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Myocardial intermediary metabolism: with special reference to the isolated, contracting, perfused rat heart
Studies of myocardial metabolism In vivo have been considerably advanced by the introduction of coronary sinus catheterization. By determining the coronary arterio-venous differences of various substrates, Sing and other workers (Goodale, Olson) have been able to describe the overall picture of …
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Effects of Hyperoxia on Thermal Tolerance and Indicators of Hypoxic Stress in Antarctic Fishes That Differ in Expression of Oxygen-Binding Proteins
… may be explained by the lack of increased cardiac (venous) oxygen supply. I have determined that cardiac lactate increases with temperature in the icefish, <i>C. aceratus</i> but not in <i>N. coriiceps</i> and that HIF-1α mRNA levels in the heart are insensitive to increases in both …
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Mitochondrial protein acetylation and left ventricular function in a model of hypertrophic cardiomyopathy and heart failure
… Protein acetylation is an important regulator of cardiac metabolism and SIRT3 is protective in heart disease. The underlying pathophysiology of heart failure in FRDA is unclear. I suspect that increased acetylation in FRDA heart mitochondria damages cardiac energy homeostasis by inhibiting …
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CARDIAC ENERGY METABOLISM IN ISCHAEMIA AND TYPE 1 DIABETES
… the myocardium. This leads to a remodelling of cardiac metabolism, which can exacerbate production of damaging reactive oxygen species and tissue necrosis upon reperfusion. In a different paradigm of metabolic disease, the type-1 diabetic heart becomes more dependent upon the oxidation of fatty …
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Hypoxia, Lipid Signalling and Tissue Metabolism in Obesity-Related Metabolic Disease
… progression of metabolic dysregulation. As lipid metabolism is highly dependent on oxygen tension, this work aimed to investigate the links between hypoxia and altered tissue metabolism accompanying the progression of obesity-related metabolic disease, with a particular focus on lipid metabolism. …
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Investigation of molecular regulatory control of the cardiac-enrich acetyl-CoA carboxlase
… the underlying molecular mechanisms directing cardiac metabolism and the changes occurring during pathogenesis are poorly understood. The chronic modification of cardiac metabolism is a process known as metabolic remodeling, which is thought to be mediated by changes in gene expression …
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The impact of erythropoietin on uraemic cardiomyopathy
… weeks prior to sacrifice at a dose of 30 μg/Kg. Cardiac function was assessed in vitro in the perfused heart and in vivo using an arterial pressure catheter. Cardiac metabolism was analysed using 13C NMR along with the activity and protein expression of key metabolic enzymes. In a separate set of …
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Enhancing Metabolism of Donor Hearts for Cardiac Transplantation
… of the organ near 0ºC to minimize donor organ metabolism and limit ongoing deterioration of the organ during storage prior to implantation (static storage). A new technique (machine perfusion preservation) is under development and works by perfusing the organ with oxygenated preservation …
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Ethanolamine as a cardioprotective agent in doxorubicin-induced cardiotoxicity
… tested whether ethanolamine protected cardiac cells by causing release of factors from fibroblasts, using H9c2 cocultured with H9c2s as a negative control. Doses of 1.6, 16, and 160 mg/kg ethanolamine were used to treat male and female C57/Bl6 mice exposed to acute (one dose of 20 mg/kg …
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Bioenergetic and Metabolic Signatures of Maternal Overnutrition in the Offspring Heart
… in mitochondrial respiratory function, substrate metabolism and oxidative stress have been implicated in offspring cardiac alterations, however these bioenergetic and metabolic phenotypes remain poorly defined. This thesis aimed to investigate cardiac mitochondrial bioenergetics and metabolism in …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… the size of myocytes. Whether changes in metabolism regulate the structural remodeling process is unknown. A likely candidate for a link between metabolism and growth in the heart is the mammalian target of rapamycin (mTOR), which couples energy and nutrient metabolism to cell growth. …
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Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase
… of MuRF1 during chronic fasting preserves cardiac function, possibly by limiting degradation of critical metabolic enzymes. Furthermore, during cardiac hypertrophy, chronic activation of AMPK also leads to cardiac dysfunction, possibly through enhanced protein degradation and metabolic …