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Showing 1 to 19 of 19 for “"Cardiac mechanics"”.
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The effects of aging on cardiac mechanics
… the hypothesis that the mechanical properties of cardiac myocytes significantly change with aging thereby contributing to the LV diastolic dysfunction. Cellular mechanical properties were determined by indenting cells with an atomic force microscope (AFM). The indentation results were interpreted …
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Parameters and algorithms to evaluate cardiac mechanics by conductance catheter
… mechanical dyssynchrony: its impact on cardiac function, the therapy for its treatment and the methods for its quantification. Specifically, we describe the conductance catheter and its use for the measurement of dyssynchrony. At the end of the Section 1, we propose a new set of indexes …
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Deep Learning Approach for the Automated Characterization of Cardiac Mechanics
Cardiac mechanics reflects the precise interplay between myocardial structure and contraction essential for sustaining the blood pumping function of the heart. Ejection fraction is the usual index of function, yet mechanical impairment and even heart failure may occur without changes in this …
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A Proper Orthogonal Decomposition-based inverse material parameter optimization method with applications to cardiac mechanics
… behaviour for soft biological tissues, such as cardiac tissue, is dependent on the formulation of appropriate constitutive laws and accurate identification of their material parameters. The main focus of this contribution is to investigate a Proper Orthogonal Decomposition with Interpolation …
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Development of an experimental system to determine the contribution of titin and collagen to passive stiffness of myocardium
… in the myocardial stiffness, hindering the cardiac mechanics, are alterations in intracellular titin and extracellular collagen matrix. Titin is a giant extensible protein, the third filament of striated muscle after actin and myosin, which provides elasticity to passive sarcomeres. The aim …
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Multi-scale analysis of cardiac myoarchitecture
… constitute the pathological basis of impaired cardiac mechanics in numerous clinical conditions, such as the remodeling heart following myocardial infarction and cardiomyopathies. To investigate the multi-scale nature of architectural disarray in the setting of myocardial disease, a dual …
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Cardiac cycle timing intervals in acute COVID-19 and recovered COVID-19 with sustained symptoms
… COVID-19 can result in both acute and sustained cardiac damage. Acute cardiac damage may be due to elevated inflammatory responses and can result in ischemia, which can lead to impairments in the cardiac cycle timing events. The purpose of this project was threefold: 1) to characterise cardiac …
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Diabetes and the Female Heart
… sex and type 2 diabetes interact to influence cardiac mechanics, energetics, and structure, focusing on cardiac excitation contraction coupling (ECC) - a critical cellular event that leads to heart muscle contraction. To achieve the project aim, I developed and applied an integrated …
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Local maximum entropy approximation-based modelling of the canine heart
… LME is then applied to a larger non-linear cardiac mechanics problem. That is simulating a healthy and a myocardial infarcted canine left ventricle (LV) during one heart beat. The LV is idealised by a prolate spheroidal ellipsoid. It undergoes expansion during the diastolic phase, addressed …
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Growth, modelling and remodelling of cardiac tissue: a multiphase approach
… placed on the importance of the development of a cardiac analysis toolbox with functionality for pathophysiological analysis of the disease. Subsequently, in order to further the understanding of the mechanisms of the disease as linked to cardiomyocyte growth and remodelling of the microstructure, …
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Development of a Micromorphic (Multiscale) Material Model aimed at Cardiac Tissue Mechanics
Computational cardiac mechanics has historically relied on classical continuum models; however, classical models amalgamate the behaviour of a material's micro-constituents, and thus only approximate the macroscopically observable material behaviour as a purely averaged response that originated on …
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Physiology-inspired deep learning for improved heart failure management
… the key issues is that central hemodynamics and cardiac mechanics, the quantities that characterize the state of a heart failure patient, are difficult to measure. Deep learning methods have shown promise for addressing problems in clinical medicine but are fundamentally limited by their opacity …
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High-speed high-fidelity computational modeling approaches for cardiac applications
… computational modeling approach for cardiac simulations, with a focus on replacement heart valves and left ventricular function. High-fidelity, structurally-based computational models were developed to simulate replacement heart valves. Through a structural constitutive model for …
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Model-based Analysis of Myocardial Microstructure for Left Ventricular Mechanics using MRI
… diffusion tensors using least squares fitting. Cardiac mechanics simulations are sensitive to the representation of microstructural orientations, as well as other factors such as loading conditions and kinematic constraints. To investigate the effects that variations in the microstructural …
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The Impact of Prolonged Strenuous Exercise on Right Ventricular Structure and Function: Insights from Novel Echocardiography and Electrocardiography
… commonly referred to as exercise induced cardiac fatigue (EICF), demonstrates a reduction in both systolic and diastolic function. RV dilatation and reduced LV filling are also evident. The mechanism responsible for this phenomenon is not fully understood, however a recent theory suggests …
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Interactions of Cardiomyocytes and Myofibroblasts: An Experimental and Theoretical Model Study
Cardiomyocytes and fibroblasts make up the majority of cells in natural myocardium. While cardiomyocytes are primarily responsible for the mechanical contraction, fibroblasts are responsible for maintaining the extracellular matrix and tissue compliance. In response to pathologies such as …
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Regional Mechanical Properties and Microstructure of Ovine Heart Chambers
<p>Mechanical properties of cardiac tissue play an important role in the normal heart function. As a baseline for understanding of physiology and pathophysiology of the heart, and for development and validation of new therapies, it is crucial to first understand the mechanical behavior of the …
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Cancer metastasis and elasticity of microenvironment
… focus of this dissertation, i.e. an in vitro, mechanics-induced metastasis-like phenotype (MLP), we also investigated the influence of the mechanical microenvironment on cell behavior in three additional projects: (1) the investigation of whether cardiac cells can interact with one another …