Global ETD Search
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Showing 1 to 20 of 26 for “"Cardiac injury"”.
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Engineering Three Dimensional In Vitro Approaches to Study Cardiac Injury and Repair
… content is predominately replaced by activated cardiac fibroblasts (CFs). This modifies the regional mechanical and electrical properties, which increases the risk for arrythmias and heart failure in heart attack survivors. Despite the high incidence of MI, current treatments to mitigate the …
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THE ROLE OF CIRCULAR RNA CDR1AS IN MACROPHAGE MEDIATED CARDIAC INJURY AND REPAIR
… infarction is the most common form of acute cardiac injury attributed to heart failure. Despite advancements in prognosis and treatment, acute MI (AMI) still bears a considerable mortality rate within the initial year, with a significant portion of patients succumbing within the initial 30 …
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ABSENCE OF V1AR ALTERS CARDIAC FUNCTION AT BASELINE AND FOLLOWING ACUTE CARDIAC INJURY
… with neurohormonal responses to the decrease in cardiac output and systemic blood pressure, such as the activation of the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system. Current treatment guidelines recommend using drugs that block β-adrenergic receptor (βAR) …
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CDK9 inhibitor treatment during the innate inflammatory and regenerative response in a zebrafish model of cardiac injury
… are crucial effectors and modulators of cardiac repair following myocardial infarction (MI). Sustained neutrophilic inflammation is detrimental for cardiac repair and associated with adverse MI outcomes. An attractive therapeutic strategy to treat acute inflammatory disorders, such as MI, …
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The current management of penetrating cardiac trauma
The vast majority of patients with penetrating cardiac injuries do not reach the hospital alive as the pre-hospital mortality rate for these injuries is in the region of 86%. The patients that do reach the hospital alive are potential survivors and it is obviously crucial that any cardiac injury is …
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Effects of Mg²⁺ pretreatment and the modulation of Mg²⁺-sensitive cardiac ion channels on Ca²⁺ paradox phenomenon in the heart
… inhibitors of TRPM7 channels on CP-induced cardiac injury in the isolated rat heart.
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INTRA-MITOCHONDRIAL INJURY DURING ISCHEMIA-REPERFUSION
Cardiac injury is increased following ischemia-reperfusion. Mitochondria are the “effector organelles” that are damaged during ischemia (ISC) when there is no blood flow. Resumption of metabolism by damaged mitochondria during reperfusion (REP) results in increased cell injury. Current therapeutic …
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Early Identification of Chemotherapy Induced Cardiotoxicity Using Structural and Functional Cardiovascular MRI
Anthracycline chemotherapies induce nonfocal cardiac injury to the left ventricular (LV) myocardium. This damage, chemotherapy induced cardiotoxicity, is difficult to detect noninvasively prior to the advancement of injury to an irreversible state with decrements in left ventricular ejection …
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Role of macrophages in larval zebrafish heart regeneration
… can completely regenerate their hearts after cardiac injury via dedifferentiation and proliferation of surviving cardiomyocytes. Macrophages are a required cell type for successful zebrafish heart regeneration and so may offer a roadmap to the optimisation of human myocardial repair. However, …
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The Role of MCL-1 in the Heart: Gateway from Life to Death
… of multiple cellular lineages, but its role in cardiac muscle has remained unclear. Here, we have demonstrated that cardiac-specific ablation of Mcl-1 results in a rapidly fatal, dilated cardiomyopathy preceded by loss of myofibrils and cardiac contractility, abnormal mitochondria …
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Neuropsychological, Psychological, and Injury Variables Associated with Post-Traumatic Stress Disorder in Individuals Who Suffered an Electrical Injury
<p>Electrical injury (EI) represents a major form of trauma that can greatly impact the individual cognitively, physically, and emotionally. EI can lead to a variety of cognitive impairments affecting attention, processing speed, motor skills, and memory. Furthermore, EI can lead to a variety of …
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Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells
… described as ischemia-reperfusion (I/R) injury. I/R is now recognized as a combination determining the final myocardial infarction size. Although the mechanisms underlying I/R-induced cardiac injury remain incompletely understood, emerging evidence suggests that intracellular Ca2+ …
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Widened mediastinum on chest radiography as a prompt for further imaging in suspected blunt traumatic aortic injury: 3-year experience at a major trauma centre
… in cases of suspected blunt traumatic aortic injury (BTAI). Evaluating the practical implementation and accuracy of this tool could improve the degree of interdepartmental agreement on its correct application. Objectives: To establish the proportion of requests by requesting clinicians citing …
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Prospective Isolation And Characterization Of Mononucleated And Binucleated Cardiomyocytes
Loss of cardiomyocytes through cardiac injury and disease substantially impairs cardiac function. Given that cardiomyocytes permanently exit the cell cycle soon after birth, the heart has traditionally been considered a terminally differentiated organ, and thus unable to effectively regenerate. …
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Acute Myocardial Infarction: The Relationship between Duration of Ischaemia and Infarct Size in Humans - Assessment by MRI and SPECT
… myocardial infarction. Biochemical markers of cardiac injury are used to estimate myocardial infarct size. The agreement between cumulative as well as peak values of biochemical markers and DE-MRI in patients with an occluded coronary artery was studied for Paper II.We showed that in order to …
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An investigation into the mechanisms, consequences and moderators of intradialytic hypotension in paediatric haemodialysis
… peak stress at the end of HD. I found rising cardiac troponin I levels in 25% of the cohort and reduced regional LV function in all the children examined. The level of dysfunction significantly correlated with actual BP, the degree of intradialytic BP fall and UF volumes. What remains unclear …
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Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
… sufficient capacity for endogenous repair after injury. We tested the hypothesis that intramyocardial administration of ephrinA1-Fc at the time of MI would promote cardiomyocyte survival, subsequently reducing infarct size and inflammatory cell infiltrate. The ephrinA1 ligand has been …
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MEF2-regulated Gtl2-Dio3 noncoding RNAs in cardiac muscle and disease
… factor is a central regulator of skeletal and cardiac muscle development. Recently, we showed that MEF2A regulates skeletal muscle regeneration through direct regulation of the Gtl2-Dio3 microRNA mega-cluster. In addition to their expression in skeletal muscle, temporal expression analysis of …
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Perfusion Solution Optimization by Substrate Alteration and Nanoparticle Delivery for Cardiac Hypothermic Machine Perfusion
… consumption, preserves ATP, reduces myocardial injury, minimizes lactate accumulation, and improves cardiac function after transplantation for storage intervals of over fourteen hours. Though HMP is more advantageous, myocardial metabolism and adjunctive protective strategies under these …
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Cardiac arrest – prognostic biomarkers and aspects of shock
… Some improvement has been seen in survival after cardiac arrest but the outcome is still poor and 50-70% of patients do not survive despite successful return of spontaneous circulation (ROSC). The cause of death is multifactorial. The majority of patients die from brain injury, but up to 35% die …
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